Table G-10, Characteristics of placebo-controlled trials of atypical antipsychotics omitted from main analyses because of high risk of bias - Psychological and Pharmacological Treatments for Adults With Posttraumatic Stress Disorder: A Systematic Review Update

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Table G-10Characteristics of placebo-controlled trials of atypical antipsychotics omitted from main analyses because of high risk of bias

Trial	Arm Dose mg/Day (N)	Duration (weeks)	Population Trauma Type	Baseline PTSD Severity^a	Mean Age (Y)	% Female % Nonwhite
Naylor et al., 2015²³⁵	G1: Aripiprazole (5 to 20) (7) G2: Placebo (7)	10	Veterans, Combat Trauma	82.29 to 90.60	34	36 50
Padala et al., 2006²³⁸	Risperidone (0.5 to 8) (11) Placebo (9)	12	Female Mixed	79.3 to 80.6	41	100 30
Rothbaum et al., 2008²⁴⁸	Risperidone (0.5 to 3) (9) Placebo (11)^a	16	Male and female Mixed	56 to 60	34	80 30
Villarreal et al., 2016²⁵⁶	G1: Quetiapine (25 to 800) (42) G2: Placebo (38)	12	Veterans w/chronic PTSD, Combat	70.60 to 75.40	52	6 47

a: This trial did not report the number of patients randomized in each group. Overall, 25 patients were randomized; the n reported is the number of participants analyzed in each group.
: mg = milligram; N = number; NR = not reported; PTSD = posttraumatic stress disorder; y = year.

Psychological and Pharmacological Treatments for Adults With Posttraumatic Stress Disorder: A Systematic Review Update [Internet].

Comparative Effectiveness Review, No. 207.

Forman-Hoffman V, Middleton JC, Feltner C, et al.

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