Table G-12, Characteristics of placebo-controlled trials of selective serotonin reuptake inhibitors omitted from main analyses because of high risk of bias - Psychological and Pharmacological Treatments for Adults With Posttraumatic Stress Disorder: A Systematic Review Update

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Table G-12Characteristics of placebo-controlled trials of selective serotonin reuptake inhibitors omitted from main analyses because of high risk of bias

Study	Arm Dose mg/Day (N)	Duration (Weeks)	Population Trauma Type	Baseline PTSD Severity^a	Mean Age (Y)	% Female % Nonwhite
Hertzberg et al., 2000¹⁷⁸	Fluoxetine (10 to 60) (6) Placebo (6)	12	Male Combat veterans	DTS 106 to 111	46	0 58
Marshall et al., 2007¹⁷⁷	Paroxetine (10 to 60) (25) Placebo (27)	10	Male and female Mixed	82.8 to 84.2	40	67 75
Schneier et al., 2015²⁴⁹	G1: Mirtazapine (15 to 45 mg) plus sertraline (25 to 200mg) (18) G2: Sertraline (25 to 200mg) plus placebo (18)	24	Adults with chronic PTSD, Mixed/multiple	PCL 58.9 to 60.0	40	64 75

a: When mean data for baseline PTSD severity were not reported for the total sample but were presented for each study arm, we provide the range across arms.
: DTS = Davidson Trauma Scale; mg = milligram; N = number; PCL = PTSD = posttraumatic stress disorder; y = year.

Psychological and Pharmacological Treatments for Adults With Posttraumatic Stress Disorder: A Systematic Review Update [Internet].

Comparative Effectiveness Review, No. 207.

Forman-Hoffman V, Middleton JC, Feltner C, et al.

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