Table G-15, Characteristics of placebo-controlled trials of tricyclic antidepressants omitted from main analyses because of high risk of bias - Psychological and Pharmacological Treatments for Adults With Posttraumatic Stress Disorder: A Systematic Review Update

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Table G-15Characteristics of placebo-controlled trials of tricyclic antidepressants omitted from main analyses because of high risk of bias

Trial	Arm Dose mg/Day (N)	Duration (Weeks)	Population Trauma Type	Baseline PTSD Severity	Mean Age (Y)	% Female %Nonwhite
Davidson et al., 1990¹⁷⁹ Davidson et al., 1993¹⁸⁰	Amitriptyline (50 to 300) (33) Placebo (29)	8	NR Combat veterans	IES 33.1	49	NR NR
Kosten et al., 1991¹⁸²	Imipramine (50 to 300) (23) Placebo (19)	8	Male Combat veterans	IES 35.6	39	0 NR
Reist et al., 1989¹⁸¹	Total (27) Desipramine (50 to 200) (NR) Placebo (NR)	4	Male Combat veterans	IES 55.2 to 56.2	38	0 NR

: Note: When mean data for baseline PTSD severity were not reported for the total sample but were presented for each study arm, we provide the range across arms.
: F = female; IES = Impact of Event Scale; mg = milligram; N = total number randomized/assigned to intervention and control groups; NR = not reported; PTSD = posttraumatic stress disorder; y = year.

Psychological and Pharmacological Treatments for Adults With Posttraumatic Stress Disorder: A Systematic Review Update [Internet].

Comparative Effectiveness Review, No. 207.

Forman-Hoffman V, Middleton JC, Feltner C, et al.

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