Table G-16Characteristics of studies directly comparing pharmacotherapies and psychotherapies omitted from main analyses because of high risk of bias

StudyArm (N)Treatment Duration (Followup)Population, Trauma TypeBaseline PTSD SeverityMean
Age (Y)		% Female
%Nonwhite
Frommberger et al., 2004212Paroxetine (11)a
CBT (10)		12 weeks
(3 and 6 months)		Male and female,
Mixed		70.54357

NR
Popiel et al., 2015242Paroxetine (57)b
PE (114)
Paroxetine + PE (57) (group not of interest to this KQ)		12 weeks
(1 yr)		Male and female,
Motor vehicle accident		SCID-I symptoms:
11.7 to 11.8		3922

NR
a

Titrated from 10 mg/day to max 50 mg/day (mean = 28 mg/day).

b

A dose of 20 mg/day was achieved in 3 to 7 days.

CBT = cognitive behavioral therapy; mg = milligram; N = number; NR = not reported; PE = prolonged exposure; PTSD = posttraumatic stress disorder; SCID-I = Structured Clinical Interview for Axis I Disorders; yr = year.

From: Appendix G, Documentation of Trials Rated High Risk of Bias

Cover of Psychological and Pharmacological Treatments for Adults With Posttraumatic Stress Disorder: A Systematic Review Update
Psychological and Pharmacological Treatments for Adults With Posttraumatic Stress Disorder: A Systematic Review Update [Internet].
Comparative Effectiveness Review, No. 207.
Forman-Hoffman V, Middleton JC, Feltner C, et al.
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