Table G-3Characteristics of exposure trials omitted from main analyses because of high risk of bias

StudyArm (N)Treatment Duration
(Followup Post Treatment)
Population Trauma TypeBaseline PTSD SeverityaMean
Age (Y)
% Female
% Nonwhite
Ahmadizadeh et al., 2013198Exposure (25)
Problem solving (25)
Combined (25)
Control (25)
15 sessions
(3 months)
Combat relatedNR42NR

NR
Arntz et al., 2007199CBT-exposure (42)
CBT-exposure (29)
Cross-over (17)
10 weeks
(1 month)
MixedPSS-SR
25.0 to 29.4
3566

28
Beidel et al., 2011201CBT-M (18)
Exposure (17)
17 weeks
(none)
Male
Combat
84.9 to
90.6
590

0
Brom et al., 1989203Desen (31)
Hypno (29)
Psychoeducation (29)
15 sessions
(3 months)
Netherlands
Mixed
IES
46.3 to 50.8
4279

NR
Butollo et al., 2015204DET (74)
CPT (74) (only 67 analyzed)
24 sessions
(6 months)
Type I Trauma
Mixed
IES-R
66 to 67
3666

NR
Feske et al., 2008209PE (11)
Usual care (13)
6 monthsNRPDS-I
34.9 to 35.2
43100

95
Foa et al., 1991210SIT (17)
PE (14)
SC (14)
Waitlist (10)
9 weeksFemale
Sexual abuse, assault
Interviewer severity rating
24.4 to 25.78
32100

27
Franklin et al., 2017211PE via iPhone (10)
PE via computer (7)
TAU (8)
10 sessions (1 month)Veterans61.1 to 74.3467

30
Ghafoori et al., 2017214PE (47)
PCT (24)
12 weeksMale and Female
Complex Trauma
53.5 to 61.23583

72
Ironson et al., 2002219EMDR (10)
PE (12)
6 weeks (3 months)Domestic violence/child sexual abusePSS-SR
26.6 to 34.6
NR77

NR
Johnson et al., 2006221Randomized (Total: 51)a
PE (Unclear)
CM (Unclear)
EMDR (Unclear)
Waitlist (14)
Mean number of weekly sessionsc
PE: 9.66
EMDR: 6.33
WL: 5.89 (3 months)
Female
Mixed
61.8 to 82.039100

17
Keane et al., 1989223Flooding (11)
Waitlist (13)
14 to 16 sessionsb
(6 months)
Male
Combat
PTSD
Symptom
Checklist
36.4 to 36.5
350

21
McLay et al., 2011232VR-exposure (10)
Usual care (10)
10 weeksActive duty service members82.8 to 83.5245

NR
Paunovic et al., 2001239Exposure (10)
CBT-M (10)
16 to 20 weeks
(6 months)
Male and female
Refugees
95.1 to 98.43815

NR
Rauch et al., 2015245PE (18)
PCT (18)
10-12 sessionsMilitary veterans
77 to 79
328

17
Ready et al., 2010246VR (6)
PCT (5)
10 sessions (6 months)Male
Combat
93.8580

46
Vera et al., 2011255PE (7)
UC (7)
15 sessionsSpanish Speaking
Puerto Ricans
Mixed
53 to 73460
100
a

The number of participants randomized to each active treatment group was not reported. A total of 27 participants from the active treatment groups were analyzed, 9 in each treatment group.

CBT-M = cognitive behavioral therapy mixed; CAPS = Clinician-Administered PTSD Scale for DSM-IV; CPT = cognitive processing therapy; CM = Counting Method; CR = cognitive restructuring; desen = desensitization; DET = dialogical exposure therapy; EMDR = eye movement desensitization and reprocessing; F = female; f/u = followup; hypno = hypnotherapy; IES = Impact of Event Scale; IES-R = Impact of Event Scale – revised; NR = not reported; PCT = present-centered therapy (a type of supportive therapy); PE = prolonged exposure; PSS = PTSD symptom scale;; relax = relaxation; SC = supportive control; SIT = stress inoculation training; y = year.

From: Appendix G, Documentation of Trials Rated High Risk of Bias

Cover of Psychological and Pharmacological Treatments for Adults With Posttraumatic Stress Disorder: A Systematic Review Update
Psychological and Pharmacological Treatments for Adults With Posttraumatic Stress Disorder: A Systematic Review Update [Internet].
Comparative Effectiveness Review, No. 207.
Forman-Hoffman V, Middleton JC, Feltner C, et al.

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