Table G-8Characteristics of placebo-controlled trials of alpha blockers omitted from main analyses because of high risk of bias

TrialArm Dose mg/Day (N)Duration (Weeks)Population Trauma TypeBaseline PTSD SeverityaMean
Age (Y)		% Female
% Nonwhite
Petrakis et al., 2016241G1: Prazosin (16) (50)
G2: Placebo (46)		13Veterans with alcohol dependence, Combat71.86 to 75.86446

19
Simpson et al., 2015250G1: Prazosin (16 or highest tolerated dose) (15)
G2: Placebo (15)		6Adults with alcohol dependence, Mixed/multiplePSS-I
31.5 to 31.6		4337

60

G = group; mg = milligrams; N = number; PSS-I = Posttraumatic Stress Disorder Symptom Scale-Interview

From: Appendix G, Documentation of Trials Rated High Risk of Bias

Cover of Psychological and Pharmacological Treatments for Adults With Posttraumatic Stress Disorder: A Systematic Review Update
Psychological and Pharmacological Treatments for Adults With Posttraumatic Stress Disorder: A Systematic Review Update [Internet].
Comparative Effectiveness Review, No. 207.
Forman-Hoffman V, Middleton JC, Feltner C, et al.
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