Table G-9, Characteristics of placebo-controlled trials of anticonvulsants omitted from main analyses because of high risk of bias - Psychological and Pharmacological Treatments for Adults With Posttraumatic Stress Disorder: A Systematic Review Update

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Table G-9Characteristics of placebo-controlled trials of anticonvulsants omitted from main analyses because of high risk of bias

Trial	Arm Dose mg/Day (N)	Duration (Weeks)	Population Trauma Type	Baseline PTSD Severity^a	Mean Age (Y)	% Female % Nonwhite
Hamner et al., 2009²¹⁵	Divalproex^a (16) Placebo (13)	10	Male and female Mixed	77.1	52	4 7
Hertzberg et al., 1999²¹⁷	Lamotrigine (25 to 500) (11) Placebo (4)	12	Male and female Mixed	SI-PTSD 44.3	43	36 71
Lindley et al., 2007²²⁸	Topiramate (50 to 200) (20) Placebo (20)	7	Male Combat veterans	61.6	53	0 37.5

a: Dose not reported; serum trough between 50-125 mcg/ml.
: mg = milligram; N = number; PTSD = posttraumatic stress disorder; SI-PTSD = Structured Interview for PTSD; y = year.

Psychological and Pharmacological Treatments for Adults With Posttraumatic Stress Disorder: A Systematic Review Update [Internet].

Comparative Effectiveness Review, No. 207.

Forman-Hoffman V, Middleton JC, Feltner C, et al.

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