Table E-1Sensitivity analysis of MDCT vs. MRI for diagnosis

Which Readers were Used for the Four Studies Reporting Multiple Readers SeparatelyMDCT SensitivityMDCT SpecificityMRI SensitivityMRI Specificity
1,1,1,1 (primary analysis)89%
(95% CI: 82% to 94%)		90%
(95% CI: 80% to 95%)		89%
(95% CI: 81% to 94%)		89%
(95% CI: 74% to 95%)
1,1,1,289%
(95% CI: 83% to 94%)		90%
(95% CI: 81% to 95%)		89%
(95% CI: 80% to 94%)		88%
(95% CI: 75% to 94%)
1,1,1,389%
(95% CI: 83% to 94%)		90%
(95% CI: 81% to 95%)		89%
(95% CI: 81% to 94%)		89%
(95% CI: 74% to 95%)
1,1,2,1No convergenceNo convergence88%
(95% CI: 80% to 93%)		90%
(95% CI: 75% to 96%)
1,1,2,2No convergenceNo convergence88%
(95% CI: 80% to 93%)		89%
(95% CI: 75% to 95%)
1,1,2,3No convergenceNo convergence88%
(95% CI: 80% to 93%)		90%
(95% CI: 75% to 96%)
1,2,1,190%
(95% CI: 82% to 94%)		90%
(95% CI: 80% to 95%)		90%
(95% CI: 80% to 95%)		89%
(95% CI: 75% to 95%)
1,2,1,290%
(95% CI: 83% to 94%)		90%
(95% CI: 81% to 95%)		90%
(95% CI: 80% to 95%)		88%
(95% CI: 75% to 94%)
1,2,1,390%
(95% CI: 83% to 94%)		90%
(95% CI: 81% to 95%)		90%
(95% CI: 80% to 95%)		89%
(95% CI: 75% to 95%)
1,2,2,189%
(95% CI: 82% to 93%)		90%
(95% CI: 80% to 95%)		89%
(95% CI: 80% to 94%)		90%
(95% CI: 75% to 96%)
1,2,2,289%
(95% CI: 82% to 93%)		90%
(95% CI: 81% to 95%)		89%
(95% CI: 79% to 94%)		89%
(95% CI: 75% to 95%)
1,2,2,389%
(95% CI: 82% to 93%)		90%
(95% CI: 81% to 95%)		89%
(95% CI: 80% to 94%)		90%
(95% CI: 75% to 96%)
1,3,1,190%
(95% CI: 82% to 94%)		90%
(95% CI: 80% to 95%)		90%
(95% CI: 80% to 95%)		89%
(95% CI: 75% to 95%)
1,3,1,290%
(95% CI: 83% to 94%)		90%
(95% CI: 81% to 95%)		90%
(95% CI: 80% to 95%)		88%
(95% CI: 75% to 94%)
1,3,1,390%
(95% CI: 83% to 94%)		90%
(95% CI: 81% to 95%)		90%
(95% CI: 80% to 95%)		89%
(95% CI: 75% to 95%)
1,3,2,189%
(95% CI: 82% to 93%)		90%
(95% CI: 80% to 95%)		89%
(95% CI: 80% to 94%)		90%
(95% CI: 75% to 96%)
1,3,2,289%
(95% CI: 82% to 93%)		90%
(95% CI: 81% to 95%)		89%
(95% CI: 79% to 94%)		89%
(95% CI: 75% to 95%)
1,3,2,389%
(95% CI: 82% to 93%)		90%
(95% CI: 81% to 95%)		89%
(95% CI: 80% to 94%)		90%
(95% CI: 75% to 96%)
2,1,1,191%
(95% CI: 84% to 95%)		89%
(95% CI: 80% to 95%)		91%
(95% CI: 82% to 95%)		89%
(95% CI: 77% to 95%)
2,1,1,291%
(95% CI: 84% to 95%)		90%
(95% CI: 81% to 95%)		90%
(95% CI: 81% to 95%)		88%
(95% CI: 78% to 94%)
2,1,1,391%
(95% CI: 84% to 95%)		90%
(95% CI: 81% to 95%)		91%
(95% CI: 82% to 95%)		89%
(95% CI: 77% to 95%)
2,1,2,190%
(95% CI: 84% to 94%)		89%
(95% CI: 79% to 94%)		90%
(95% CI: 81% to 94%)		90%
(95% CI: 78% to 96%)
2,1,2,2No convergenceNo convergence89%
(95% CI: 81% to 94%)		89%
(95% CI: 78% to 95%)
2,1,2,3No convergenceNo convergence90%
(95% CI: 81% to 94%)		90%
(95% CI: 78% to 96%)
2,2,1,192%
(95% CI: 84% to 96%)		89%
(95% CI: 80% to 95%)		92%
(95% CI: 82% to 96%)		89%
(95% CI: 78% to 95%)
2,2,1,292%
(95% CI: 84% to 96%)		90%
(95% CI: 81% to 95%)		91%
(95% CI: 81% to 96%)		88%
(95% CI: 78% to 94%)
2,2,1,392%
(95% CI: 84% to 96%)		90%
(95% CI: 81% to 95%)		92%
(95% CI: 82% to 96%)		89%
(95% CI: 78% to 95%)
2,2,2,190%
(95% CI: 84% to 94%)		89%
(95% CI: 80% to 94%)		90%
(95% CI: 81% to 95%)		90%
(95% CI: 78% to 96%)
2,2,2,290%
(95% CI: 84% to 94%)		90%
(95% CI: 80% to 95%)		90%
(95% CI: 81% to 95%)		89%
(95% CI: 78% to 95%)
2,2,2,390%
(95% CI: 84% to 94%)		90%
(95% CI: 80% to 95%)		90%
(95% CI: 81% to 95%)		90%
(95% CI: 78% to 96%)
2,3,1,192%
(95% CI: 84% to 96%)		89%
(95% CI: 80% to 95%)		92%
(95% CI: 82% to 96%)		89%
(95% CI: 78% to 95%)
2,3,1,292%
(95% CI: 84% to 96%)		90%
(95% CI: 81% to 95%)		91%
(95% CI: 81% to 96%)		88%
(95% CI: 78% to 94%)
2,3,1,392%
(95% CI: 84% to 96%)		90%
(95% CI: 81% to 95%)		92%
(95% CI: 82% to 96%)		89%
(95% CI: 78% to 95%)
2,3,2,190%
(95% CI: 84% to 94%)		89%
(95% CI: 80% to 94%)		90%
(95% CI: 81% to 95%)		90%
(95% CI: 78% to 96%)
2,3,2,290%
(95% CI: 84% to 94%)		90%
(95% CI: 80% to 95%)		90%
(95% CI: 81% to 95%)		89%
(95% CI: 78% to 95%)
2,3,2,390%
(95% CI: 84% to 94%)		90%
(95% CI: 80% to 95%)		90%
(95% CI: 81% to 95%)		90%
(95% CI: 78% to 96%)

Note: “No convergence” means that the metandi command in stata did not converge on estimates, even after increasing the number of integration points to the maximum of 15.

From: Appendix E, Sensitivity Analyses for Meta-Analyses Involving Multiple Readers per Study

Cover of Imaging Tests for the Diagnosis and Staging of Pancreatic Adenocarcinoma
Imaging Tests for the Diagnosis and Staging of Pancreatic Adenocarcinoma [Internet].
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Treadwell J, Mitchell M, Eatmon K, et al.
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