| Treatment | Does it improve symptoms of insomnia disorder? | Does it have side effects? |
|---|---|---|
| Non-medicine treatment | ||
| CBT-I | Yes | No |
| Medicines | ||
| Non-benzodiazepine hypnotics | ||
| Eszopiclone (Lunesta®) | Yes, in the short term | Yes, possibly serious |
| Zolpidem (Ambien®) | Yes, in the short term | Yes, possibly serious |
| Zaleplon (Sonata®) | Maybe, in the short term | Yes, possibly serious |
| Orexin receptor antagonist | ||
| Suvorexant (Belsomra®) | Yes, in the short term | Yes, possibly serious |
| Melatonin agonist | ||
| Ramelteon (Rozerem®) | Maybe, in the short term | Yes, possibly serious |
| Antidepressant | ||
| Doxepin (Silenor®) | Maybe, in the short term | Yes, possibly serious |
| Benzodiazepine hypnotic | ||
| Temazepam (Restoril®) | Not enough research to know | Yes, possibly serious |
From: Managing Insomnia Disorder
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