Table 13Summary of Recommendations in Included Guideline

RecommendationsStrength of Evidence and Recommendations
NICE 201730
  • “Offer people with advanced PD BMT, which may include intermittent apomorphine injection and/or continuous subcutaneous apomorphine infusion.
  • Do not offer DBS to people with PD whose symptoms are adequately controlled by BMT.
  • Consider DBS for people with advanced PD whose symptoms are not adequately controlled by BMT” (p 215)
Adverse events
  • Strength of evidence: very low to moderate
Symptom severity
  • Strength of evidence: low to moderate
Neuropsychological outcomes
  • Strength of evidence: very low to moderate
Health related quality of life – patient
  • Strength of evidence: moderate to high
Medication load
  • Strength of evidence: moderate

BMT = best medical therapy; NICE = National Institute for Health and Care Excellence; PD = Parkinson’s disease

From: Deep Brain Stimulation for Parkinson’s Disease: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines

Cover of Deep Brain Stimulation for Parkinson’s Disease: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines
Deep Brain Stimulation for Parkinson’s Disease: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines [Internet].
Lachance C, Spry C, MacDougall D.
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