Table 7.

Recommended Surveillance for Individuals with Mucopolysaccharidosis Type III

System/ConcernEvaluationFrequency
Neurologic Monitor treatment effectiveness in those w/seizures.As clinically indicated
Development Monitor developmental capabilities & educational needs.Annually
Psychiatric/
Behavioral issues 		Assessment of destructive or disruptive behaviorsAs clinically indicated
Musculoskeletal
  • Monitor joint mobility; assessment by orthopedist.
  • Monitor BMD w/DXA & vitamin D metabolism studies.
Hearing Assessment by audiologist & otolaryngologistAnnually
Cardiovascular Echocardiogram & EKG to assess for valvular disease & conduction system defects
Ocular Ophthalmologic assessmentAs clinically indicated

BMD = bone mineral density; DXA = dual-energy x-ray absorptiometry

From: Mucopolysaccharidosis Type III

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