Table 5.

Recommended Surveillance for Individuals with a WT1 Disorder

System/ConcernEvaluationFrequency
Glomer-
ulopathy 		Persistent proteinuria /
SRNS		Monitor for 1st appearance of proteinuria.Every 6 mos until age 10 yrs; annually after age 10 yrs 1
CNSMonitor for 1st appearance of proteinuria.During first 3 mos of life 2
CKDMonitor progression of known CKD.Every 2 yrs
Disorder of testicular
development 		Monitor timing & progression of puberty.Per treating multidisciplinary team (medical geneticist, endocrinologist, urologist, psychologist)
Wilms tumor Monitor for 1st appearance of Wilms tumor.Abdominal US every 3 mos until age 7 yrs 3
CAKUT Follow up of known kidney &/or urinary tract anomaliesPer treating nephrologist &/or urologist

CAKUT = congenital anomalies of the kidney and urinary tract; CKD = chronic kidney disease; CNS = congenital nephrotic syndrome; SRNS = steroid-resistant nephrotic syndrome; US = ultrasound

1.
2.
3.

From: WT1 Disorder

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