Table 11, Summary of utility evidence - Emergency and acute medical care in over 16s: service delivery and organisation

Study	Country	Population	Year of data	Quality of life meausre	Follow up	Sample size	Stratification of findings	Inclusion?
AGBORSAN GAYA 2013³	Canada	Random sample from a community population with 16 common self-reported chronic conditions	NR	EQ5D	health over last 12 months	4946	By condition, level of multi-morbidity, age, gender	Selectively excluded in light of Ara 2011
ARA 2011⁹	UK	General population - Health Survey for England	2003-6	EQ-5D	Cross-sectional study	41,174	Presence/absen ce of a chronic condition	Inclusion for long term quality of life
BAGSHAW 2014¹²	USA	Critical care patients age >=50	2010	EQ5D VAS and SF12	6 months and 12 months	421	By clinical frailty score and age	Inclusion for long term quality of life
COURTNEY 2009⁴⁵	Australia	Patients with an acute medical admission age≥65 with at least one risk factor for readmission	2004 to 2006	SF12	4, 12 and 24 weeks	128	NR	Excluded due to utility measure employed
ERIKSEN 1998⁶⁰	Norway	Admitted patients	1993	Experts determined score	6 weeks	479	NR	Excluded due to utility measure employed
GOODACRE 2012⁶⁷	UK	Admitted to hospital by ambulance	2007 to 2008	EQ5D	30 days after admission	3028	by age, gender, condition	Inclusion for post-acute phase
HUTCHINS ON 2013⁸⁵	Australia	Patients with comorbid chronic condition	2007 to 2009	AQOL	questionnaire shortly after first visit	210		Excluded due to utility measure employed
HUTCHINS ON 2015⁸⁶	Australia	Patients with chronic condition at high risk of emergency admission	2007-2012	AQOL	questionnaire shortly after first visit	1999		Excluded due to utility measure employed
ROUND 2004¹⁶⁴	UK	Patients with age>= 70 and experiencing acute care	prospective cohort - 1999-2000	SF36 and EQ5D	Time zero, 6 months post admission	367 at time zero, 254 at 6 mo	community versus district general hospital	Inclusion for subgroup of patients over 70.
SACANELLA 2011¹⁷⁰	Spain	Patients with age>= 65 admitted to ICU with medical condition	NR	EQ5D	Time zero, discharge, 12 months	112	For ages 65-74 and 75 +	Selective exclusion in light of Bagshaw et al. which stratifies by CFS
SAUKKONEN 2006¹⁷⁵	Finland	Medical ICU patients	2002-2004	15 D	6 months post ICU admission	1167	ED versus non ED patients going to MICU	Exclude due to QoL measure employed
VAINIOLA 2011¹⁹²	Finland	Emergency patients admitted to ICU/HDU	2003 and 2004	EQ5D and 15D	6 and 12 months post treatment	937	By presentation	Selective exclusion in light of Bagshaw et al. which stratifies by CFS
VEDIO2000 Vedio, 2000 VEDIO2000 /id	UK	Patients discharged from ICU	1994-5	SF36	6 months	115	Medical / surgical admissions	Excluded because of outcome measure

Study

Country

Population

Year of data

Quality of life meausre

Follow up

Sample size

Stratification of findings

Inclusion?

AGBORSAN GAYA 2013³

Canada

Random sample from a community population with 16 common self-reported chronic conditions

EQ5D

health over last 12 months

4946

By condition, level of multi-morbidity, age, gender

Selectively excluded in light of Ara 2011

ARA 2011⁹

General population - Health Survey for England

2003-6

EQ-5D

Cross-sectional study

41,174

Presence/absen ce of a chronic condition

Inclusion for long term quality of life

BAGSHAW 2014¹²

USA

Critical care patients age >=50

2010

EQ5D VAS and SF12

6 months and 12 months

421

By clinical frailty score and age

Inclusion for long term quality of life

COURTNEY 2009⁴⁵

Australia

Patients with an acute medical admission age≥65 with at least one risk factor for readmission

2004 to 2006

SF12

4, 12 and 24 weeks

128

Excluded due to utility measure employed

ERIKSEN 1998⁶⁰

Norway

Admitted patients

1993

Experts determined score

6 weeks

479

Excluded due to utility measure employed

GOODACRE 2012⁶⁷

Admitted to hospital by ambulance

2007 to 2008

EQ5D

30 days after admission

3028

by age, gender, condition

Inclusion for post-acute phase

HUTCHINS ON 2013⁸⁵

Australia

Patients with comorbid chronic condition

2007 to 2009

AQOL

questionnaire shortly after first visit

210

Excluded due to utility measure employed

HUTCHINS ON 2015⁸⁶

Australia

Patients with chronic condition at high risk of emergency admission

2007-2012

AQOL

questionnaire shortly after first visit

1999

Excluded due to utility measure employed

ROUND 2004¹⁶⁴

Patients with age>= 70 and experiencing acute care

prospective cohort - 1999-2000

SF36 and EQ5D

Time zero, 6 months post admission

367 at time zero, 254 at 6 mo

community versus district general hospital

Inclusion for subgroup of patients over 70.

SACANELLA 2011¹⁷⁰

Spain

Patients with age>= 65 admitted to ICU with medical condition

EQ5D

Time zero, discharge, 12 months

112

For ages 65-74 and 75 +

Selective exclusion in light of Bagshaw et al. which stratifies by CFS

SAUKKONEN 2006¹⁷⁵

Finland

Medical ICU patients

2002-2004

15 D

6 months post ICU admission

1167

ED versus non ED patients going to MICU

Exclude due to QoL measure employed

VAINIOLA 2011¹⁹²

Finland

Emergency patients admitted to ICU/HDU

2003 and 2004

EQ5D and 15D

6 and 12 months post treatment

937

By presentation

Selective exclusion in light of Bagshaw et al. which stratifies by CFS

VEDIO2000 Vedio, 2000

VEDIO2000 /id

Patients discharged from ICU

1994-5

SF36

6 months

115

Medical / surgical admissions

Excluded because of outcome measure

From: Chapter 41, Cost-effectiveness analyses

Emergency and acute medical care in over 16s: service delivery and organisation.

NICE Guideline, No. 94.

National Guideline Centre (UK).

London: National Institute for Health and Care Excellence (NICE); 2018 Mar.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.

Table 11Summary of utility evidence