| EDC | Source | Possible Outcome |
|---|---|---|
| Perchlorate | Oxidant in solid rocket propellants, fireworks, airbag deployment systems, etc. | Interferes with the uptake of iodide into the thyrocyte by sodium/iodide symporter (NIS) |
| Thiocyanates | Cigarettes | Interferes with the uptake of iodide |
| Isoflavones (Phytoestrogens) | Soy protein | TPO inhibitors resulting in goiter in children |
| PCB | Paints Plastics | They can act as TR agonist or antagonist, or reduce circulating levels of T4 resulting in relative hypothyroidism, increase in expression of glial fibrillar acidic protein leading to neurotoxicity in children. |
| BPA | Plastics Food cans Dental sealants | Binds to TRβ and antagonizesT3 activation. It can block T3-induced oligodendrocyte development from precursor cells, resulting in ADHD. Halogenated BPA can act as TR agonists, TBBPA bind to TR and induces GH3 cell proliferation and GH production. |
PCB - Polychlorinated biphenyls, BPA - Bisphenol A, ADHD- Attention Deficit Hyperactivity Disorder, TBBPA - Tetrabromobisphenol A, T4 - tetraiodothyronine (thyroxine), T3 - triiodothyronine, TPO – Thyroperoxidase, TR – Thyroid Receptor, TH - Thyroid hormone, GH- Growth Hormone
From: Endocrine Disruptor Chemicals
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