| EDCs | Main Sources | Possible Mechanism | Clinical condition |
|---|---|---|---|
| Alkylphenols | Detergents Shampoos Pesticide | Mimics estrogen | Breast cancer |
| Phthalates | Plastic products Personal care products (perfume, moisturizer) | Not yet known | Testicular and ovarian toxicants |
| Polychlorinated biphenyls (chlorinated/ halogenated/ TBBPA) | Paints Plastics Lubricants Electrical applications | Estrogenic and anti-androgenic activity Indirectly regulate circulating gonadal hormones. Inducers of CYP1A and CYPIIB Decreased NMDA receptor binding in striatum, frontal cortex and hippocampus, cerebellum Reduced glutamate and dopamine Acts at AhR signaling pathways resulting in cytotoxic effects | Neurobehavioral defects like cognitive deficits in children Neurotoxicity Thyroid toxicity Susceptibility to infections Cancers (especially Breast Cancer) Infertility |
TBBPA- Tetrabromobisphenol A, CYP - cytochrome P450 enzymes, NMDA- N-methyl-D-aspartate, AhR - aryl hydrocarbon receptor
From: Endocrine Disruptor Chemicals
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