Table 2: [Relative Enzymatic Activity of UGT1A1 Variants]. - Medical Genetics Summaries

Allele name	Variant	Relative activity	Potential impact on drug metabolism	CPIC functional status^e
UGT1A11*	None (promoter [TA]₆TAA)	100%^a	Normal	Normal function
UGT1A16*	p.Arg71Gly	70%^b	Slower	Decreased function
UGT1A127*	p.Pro229Gln	50% ^c	Slower	Decreased function
UGT1A128*	Promoter (TA)₇TAA	65%^a	Slower	Decreased function
UGT1A136*	Promoter (TA)₅TAA	130%^a	Faster	Increased function
UGT1A137*	Promoter (TA)₈TAA	50%^a	Slower	Decreased function
UGT1A160*	c.-3279T>G	60%^d	Slower	Normal function^f

Allele name

Variant

Relative activity

Potential impact on drug metabolism

CPIC functional status^e

UGT1A1*1

None (promoter [TA]₆TAA)

100%^a

Normal

Normal function

UGT1A1*6

p.Arg71Gly

70%^b

Slower

Decreased function

UGT1A1*27

p.Pro229Gln

50% ^c

Slower

Decreased function

UGT1A1*28

Promoter (TA)₇TAA

65%^a

Slower

Decreased function

UGT1A1*36

Promoter (TA)₅TAA

130%^a

Faster

Increased function

UGT1A1*37

Promoter (TA)₈TAA

50%^a

Slower

Decreased function

UGT1A1*60

c.-3279T>G

60%^d

Slower

Normal function^f

From: Belinostat Therapy and UGT1A1 Genotype

Medical Genetics Summaries [Internet].

Pratt VM, Scott SA, Pirmohamed M, et al., editors.

Bethesda (MD): National Center for Biotechnology Information (US); 2012-.

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