| References | No of Patients | Endpoints Evaluated | Findings | Notes |
|---|---|---|---|---|
| Sankaran et al, 199924 | 88 | Multiple acute rejection episodes; graft survival | Recipient -1082 G/G associated with multiple rejections (p=0.02); Recipient -1082 G/G and TNF -308A associated to steroid-resistant rejections | Only in HLA-DR mismatched transplants |
| Tian et al, 200225 | 115 | Acute rejection | Recipient -1082 G/G and G/A associated with higher incidence of acute rejection (p<0.01) | |
| Pelletier et al, 200026 | 100 | Acute rejection; serum creatinine | Association of recipient -1082 G/G with increased incidence of acute rejection (p=0.02); No association with serum creatinine | Only in recipients with TNF -308 G/G |
| Hutchings et al, 200227 | 105 | Acute rejection | Association of recipient -1082 A/A with decreased incidence of acute rejection (p=0.006) | Only in African American patients |
| George et al, 200128 | 105 | Acute rejection | Association of recipient -1082 A/A with increased incidence acute rejection (p=0.01) | |
| Poole et al, 200129 | 120 | Acute rejection incidence; multiple rejection episodes | Recipient -1082 A/A and A/G associated (trend) with multiple rejection episodes (p=0.07) Donor -1082 A frequency decreased in multiple rejectors group (p=0.06) Recipient -1082 A negative/donor -1082 A positive decreased in multiple rejectors group (p=0.04) | Only in HLA-DR mismatched transplants |
| Marshall et al, 200030 | 209 | Acute rejection | No association with recipient genotype, irrespective of HLA-DR mismatch | Two independent sets of patients studied |
| Hahn et al, 200131 | 120 | Acute rejection | No association with recipient genotype, irrespective of HLA-DR mismatch | |
| Asderakis et al, 200132 | 88 | Acute rejection; graft survival | No association of recipient genotype either with incidence or severity of acute rejection or with graft survival | |
| Poli et al, 200133 | 169 | Acute rejection, serum creatinine, long-term survival | No association of recipient genotype with acute rejection or serum creatinine levels Recipient -1082 A/A genotype associated with survival of more than 15 years (p=0.03) | |
| Kobayashi et al, 199934 | 120 | Incidence and severity of acute rejection | Association of recipient - 1064 allele 12 repeats with incidence and severity of acute rejection (p=0.05 and 0.0009, respectively) | HLA-haploidentical living-related transplants |
| Marshall et al, 200135 | 145 | Acute rejection | No association with donor genotype | |
| Mytilineos & Opelz, 200236 | 4700 | Graft survival | No association with recipient genotype | 2100 second transplants included |
| Alamartine et al, 200337 | 140 | Skin carcinoma after renal transplantation | Association of recipient -1082, -819,-592 GCC genotype with squamous skin carcinoma (p=0.003) | Correlation of IL-10 in vitro production with predicted phenotype |
From: IL-10 Gene Polymorphisms in Transplantation
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