Table 11, Pain relief in systematic reviews of acetaminophen compared with NSAID - Analgesics for Osteoarthritis

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Systematic Review	Date of Last Search	Number of Head-to-Head Trials Included	Main Results for Outcome of General or Rest Pain
Towheed, 2006¹⁸⁰	Through 7/05	12 (4 trials evaluated coxibs)	NSAIDs superior for rest pain (3 trials, SMD 0.20, 95% CI 0.03 to 0.36), overall pain (8 trials, SMD 0.25, 95% CI 0.17 to 0.33), WOMAC pain (2 trials, SMD 0.24, 95% CI 0.09 to 0.38), WOMAC stiffness (2 trials, SMD 0.20, 95% CI 0.05 to 0.34), WOMAC function (2 trials, SMD 0.25, 95% CI 0.11 to 0.40), and global assessment of efficacy (2 trials, RR 1.2, 95% CI 1.1 to 1.4)
Zhang, 2004¹⁸²	Through 7/03	8 (3 trials evaluated coxibs)	NSAIDS superior using WOMAC scale (SMD 0.3, 95% CI 0.17 to 0.44) and clinical response rate (RR 1.24, 95% CI 1.08 to 1.41)
Lee, 2004¹⁷⁹	Through 2/03	6 (1 trial evaluated a coxib)	NSAIDs superior for rest pain (weighted mean difference 6.33, 95% CI 3.41 to 9.24)
Wegman, 2004¹⁸¹	Through 12/01	3 (no trials evaluated coxibs)	NSAIDs superior for general/rest pain (SMD 0.33, 95% CI 0.15 to 0.51)

: CI = confidence interval; NSAID = nonsteroidal anti-inflammatory drug; RR = relative risk; SMD = standardized mean difference; WOMAC = Western Ontario and McMaster Universities Osteoarthritis Index

Analgesics for Osteoarthritis: An Update of the 2006 Comparative Effectiveness Review [Internet].

Comparative Effectiveness Reviews, No. 38.

Chou R, McDonagh MS, Nakamoto E, et al.

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