Table 19Head-to-head trials of gastroprotective agents263

ComparisonReductions in Ulcer Risk
GastricDuodenal
Misoprostol vs. ranitidine* (2 trials; n=600)RR 0.12
95% CI 0.03 to 0.89		No differences
Omeprazole* vs. ranitidine* (1 trial, n=425)RR 0.32
95% CI 0.17 to 0.62		RR 0.11
95% CI 0.01 to 0.89
PPI† vs. misoprostol‡ (2 trials; n=838)No differencesRR 0.29
95% CI 0.15 to 0.56

CI = confidence interval; PPI = Proton pump inhibitor; RR = relative risk

*

Standard dose

†

Omeprazole or lansoprazole standard doses

‡

Secondary prophylaxis trials – misoprostol doses 400 mcg daily in one trial and 800 mcg daily in another trial

From: Results

Cover of Analgesics for Osteoarthritis
Analgesics for Osteoarthritis: An Update of the 2006 Comparative Effectiveness Review [Internet].
Comparative Effectiveness Reviews, No. 38.
Chou R, McDonagh MS, Nakamoto E, et al.
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