Dickson, 1991298 Fair | OA of knee 235 | Piroxicam 0.5% gel tid Ibuprofen 400 mg po tid | 4 weeks | Patient global assessment ‘good’ ‘or excellent’: 64% vs. 60% Pain during day (0–9): 3.0 vs. 3.0, p=0.56 Pain at night (0–9): 2.0 vs. 2.0, p=0.54 |
Sandelin, 1997300 Fair | OA of knee 208 | Eltenac 1% gel tid Diclofenac 50 mg po bid | 4 weeks | Lequesne Index (0–24): 6.3 vs. 6.9 Pain (0–100 VAS): 28 vs. 30 |
Zacher, 2001304 Not rated* | OA of fingers 321 | Diclofenac 1% gel Ibuprofen 400 mg po tid | 3 weeks | >=40% improvement in pain on 100 mm VAS: 40% vs. 34%, RR 1.2 (95% CI 0.88–1.6) |
Tugwell, 2004303 Good | OA of knee 622 | Diclofenac 1.5% in 45.5% DMSO tid Diclofenac 50 mg po tid | 12 weeks | Clinical responder (OMERACT VI criteria38): 66% vs. 70% WOMAC Pain (0–500, mean change): −118 vs. −134, p=0.10 WOMAC Physical Function (0–1700, mean change): −348 vs. −438, p=0.008 WOMAC Stiffness (0–200, mean change): −45 vs. −52, p=0.14 Patient global assessment (0–100, mean change): −27 vs. −32, p=0.08 |
Rother, 2007299 Good | OA of knee 270 | Ketoprofen 110 mg in 4.8 g transferone every 12 hours Celecoxib 100 mg every 12 hours | 6 weeks | Clinical responder (OMERACT criteria): 69% vs. 64% Patient global assessment of response “good” or “excellent”: 46% vs. 39% WOMAC Pain (0 to 100, mean change): −19 vs. −21 WOMAC Physical Function (0 to 100, mean change): −16 vs. −18 WOMAC Stiffness (0 to 100, mean change): −15 vs. −17 Use of rescue medication (capsules/day): 0.24 vs. 0.16 |
Underwood, 200849 Fair | OA of knee 282 | Advice to use a topical NSAID, preferably ibuprofen Advice to use an oral NSAID | 1 year | Mean differences in change WOMAC Pain (0 to 100): 1 (95% CI −4 to 6) WOMAC Stiffness (0 to 100): 0 (95% CI −6 to 5) WOMAC Physical Function (0 to 100): 3 (95% CI −2 to 7) WOMAC Global (0 to 100): 2 (95% CI −2 to 6) SF-36: No differences at 1 year in mental or physical component summary scores |
Simon, 2009301 Good | OA of knee 305 | Diclofenac 1.5% in 45.5% DMSO qid Diclofenac 100 mg po qd | 12 weeks | WOMAC Pain (0 to 20, mean change): −6.0 vs. −6.4, p=0.43 WOMAC Physical Function (0 to 68, mean change): −16 vs. −18, p=0.32 WOMAC Stiffness (0 to 8, mean change): −1.9 vs. −2.1, p=0.60 Patient global assessment (0 to 4, mean change): −1.4 vs. −1.4, p=0.44 |
Tiso, 2010302 Fair | Chronic knee pain (presumed OA of knee) 20 | Ibuprofen 4% gel qid Ibuprofen 800 mg po tid | 2 weeks | WOMAC Pain (0 to 500, mean change): −83 vs. −84, NS WOMAC Physical Function (0 to 1700, mean change): −312 vs. −323, NS WOMAC, Stiffness (0 to 200, mean change): −48 vs. −26, NS SF-36: No differences on mental component score, physical component score, or subscales |