| Author, Year Quality | Condition Number Enrolled Comparison | Withdrawal due to Adverse Events Any Adverse Events | Gastrointestinal Adverse Events | Skin Adverse Events | Other Adverse Events |
|---|---|---|---|---|---|
| Dickson, 1991298 Fair | OA of knee 235 Topical piroxicam 0.5% vs. ibuprofen 400 mg po tid | Withdrawal due to adverse events: 7.7% (9/117) vs. 5.9% (7/118) Any adverse event: 26% (31/117) vs. 23% (27/118) | Upper GI: 10% vs. 8.5% Other GI: 2.6% vs. 0.8% | Rash: 0.8% vs. 0.8% | CNS: 6.0% vs. 6.8% |
| Sandelin, 1997300 Fair | OA of knee 208 Eltenac 1% gel vs. diclofenac 50 mg po bid | Withdrawal due to adverse events: 3.2% (4/126) vs. 1.2% (1/82) Any adverse event: 27% (34/126) vs. 24% (20/82) | GI: 4.8% vs. 13% | Local skin reaction: 13% vs. 1.2% | CNS: 9.5% vs. 7.3% |
| Zacher, 2001304 Not rated* | OA of fingers 321 Diclofenac 1% gel vs. ibuprofen 400 mg po tid | Withdrawal due to adverse events: 3.0% (5/165) vs. 10% (16/156) | Data not available | Data not available | Data not available |
| Tugwell, 2004303 Good | OA of knee 622 Diclofenac 1.5% in 45.5% DMSO vs. diclofenac 50 mg po tid | Withdrawal due to adverse events: 21% (64/311) vs. 25% (79/311) | Any GI adverse event: 35% vs. 48% (p=0.0006); severe 7.4% vs. 21% (p=0.002) Abdominal pain: 12% vs. 22% (p=0.0008); severe 5.6% vs. 19% Diarrhea: 9% vs. 17% (p=0.001), severe 3.7% vs. 17% Dyspepsia: 15% vs. 26% (p=0.001), severe 4.2% vs. 14% Melena: 1% vs. 2% (p=0.36) Nausea: 8% vs. 13% (p=0.36) Vomiting: 2% vs. 2% (p=0.56) AST normal to abnormal: 2% vs. 10% (p=0.0001) Hemoglobin (g/l): normal to abnormal 2% vs. 10% (p<0.0001), mean change from baseline 0.9 vs. −2.2 (p<0.0001) | Dry skin: 27% vs. 1% (p<0.0001 Rash: 12% vs. 2% (p<0.0001 Pruritus: 6% vs. 0.6% (p<0.0001) Vesiculobullous rash: 5% vs. 0% (p<0.0001) | Asthma: 0.6% vs. 3% (p=0.002) Dizziness: 0.6% vs. 4% (p=0.002) Dyspnea; 0% vs. 2% (p=0.01) Mean blood pressure increased 5 mm Hg or greater: 24% vs. 28% (p=0.30) Creatinine: normal to abnormal 1% vs. 3% (p=0.08), mean change from baseline 0.3 vs. 3.3 (p=0.003) |
| Rother, 2007299 Good | OA of knee 270 Ketoprofen 110 mg in 4.8 g transferone q 12 h vs. celecoxib 100 mg every 12 hours | Withdrawal due to adverse events: 17% (23/138) vs. 14% (18/132), p=0.15 Any adverse event: 54% vs. 50% | GI adverse event: 9.4% vs. 14% Abdominal pain, upper: 1.4% vs. 3.0% Diarrhea: 0.7% vs. 1.5% Dyspepsia: 0.7% vs. 3.0% Gastritis: 2.2% vs. 0% Nausea: 1.4% vs. 2.3% | Any skin: 28% vs. 20% Dermatitis allergic: 1.4% vs. 0.8% Erythema: 21% vs. 14% Exanthema: 2.2% vs. 1.5% Pruritus: 0% vs. 3.8% Skin irritation: 1.4% vs. 0% Urticaria: 1.4% vs. 0.8% | Any respiratory, thoracic, and mediastinal disorders: 12% vs. 11% |
| Underwood, 200849 Fair | OA of knee 282 Advice to use topical NSAID (preferably ibuprofen) vs. advice to use an oral NSAID (preferably ibuprofen) | Any defined minor adverse event: 53% vs. 57% (mean difference 0%, 95% CI − 11% to 12%) | GI minor event: 42% vs. 40% (mean difference 2%, 95% CI −9% to 14%) Liver enzymes >upper limit of normal: 2.7% vs. 2.2 (mean difference 0.4%, 95% CI −3.4% to 4.3%) Change in hemoglobin (g/l): 0.2 vs. 0.7, difference 0.5 (95% CI −1.3 to 2.3) | Not reported | Unplanned hospitalization through 1 year (rate per 100 per year): 4.5 vs. 1.4 (mean difference 3.1, 95% CI −1.0 to 7.2) Renovascular minor adverse event: 16% vs. 15% (mean difference 1%, 95% CI −8% to 9%) Respiratory: 7% vs. 17% (mean difference −9%, 95% CI −17% to −2%) Change in systolic blood pressure (mm Hg): 2.5 vs. 4.4, difference 1.9 (95% CI −1.7 to 5.5) Change in serum creatinine (micromol/l): 2.4 vs. − 1.3, difference −3.7 (−6.5 to −0.9) |
| Simon, 2009301 Good | OA of knee 305 Diclofenac 1.5% in 45.5% DMSO qid vs. diclofenac 100 mg po qd | Withdrawal due to adverse events: 10% (16/154) vs. 13% (19/151) Any adverse event: 62% vs. 62% Serious adverse event: 0% vs. 0.7% | Any GI adverse event: 6.5% vs. 24% Abdominal pain: 3.2% vs. 7.3% Dyspepsia: 2.6% vs. 4.0% Diarrhea; 1.3% vs. 4.6% Liver function tests abnormal: 1.9% vs. 7.9%; AST normal to abnormal 6.9% vs. 20% Rectal hemorrhage: 0.6% vs. 0% Nausea: 0% vs. 2.0% Hemoglobin normal to abnormal: 2.1% vs. 5.8%; mean change (g/l): −1.0 vs. −3.8 | Any skin/appendages event: 27% vs. 7.3% Dry skin: 18% vs. 2.6% Contact dermatitis: 2.6% vs. 0.7% Rash: 2.6% vs. 0% Contact dermatitis with vesicles: 1.9% vs. 0.7% | Respiratory disorder: 3.2% vs. 5.3% Creatinine normal to abnormal: 2.8% vs. 7.2%; mean change (micromol/l): −0.4 vs. 3.1 |
| Tiso, 2010302 Fair | Chronic knee pain (presumed OA of knee) 20 Ibuprofen 4% gel qid vs. ibuprofen 800 mg po tid | Not reported | Stomachache: 0% vs. 10% Constipation: 0% vs. 10% Diarrhea: 0% vs. 10% | Rash: 11% vs. 0% | Dizziness: 11% vs. 20% Headache: 0% vs. 20% |
Non-English language study, data as reported in Mason et al305.
From: Results
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