Table 6Rate ratios (95% CI)*: COX-2 inhibitor relative to nonselective NSAID121

NSAID GroupVascular EventsMyocardial InfarctionStrokeVascular Death
Any nonselective NSAID1.2 (0.97 to 1.4)1.5 (1.2 to 2.0), p=0.00090.83 (0.62 to 1.1)0.97 (0.69 to 1.4)
Any nonnaproxen, nonselective NSAID0.88 (0.69 to 1.1)1.2 (0.85 to 1.7)0.62 (0.41 to 0.95), p=0.030.67 (0.43 to 1.1)
Naproxen1.6 (1.2 to 2.0)2.0 (1.4 to 3.0), p=0.00021.1 (0.73 to 1.6)1.5 (0.90 to 2.4)

CI = confidence interval; COX = cyclooxygenase; NSAID = nonsteroidal anti-inflammatory drug

*

Rate ratios below 1 favor COX-2 inhibitors, and rate ratios above 1 favor NSAIDs

From: Results

Cover of Analgesics for Osteoarthritis
Analgesics for Osteoarthritis: An Update of the 2006 Comparative Effectiveness Review [Internet].
Comparative Effectiveness Reviews, No. 38.
Chou R, McDonagh MS, Nakamoto E, et al.
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