Table 9Systematic review of tolerability of COX-2s compared with NSAIDs

ReviewAE incidenceWithdrawals
Overall RR (95% CI)GI-related RR (95% CI)Any AE RR (95% CI)GI-related RR (95% CI)
Celecoxib vs. NSAIDs for OA/RA
Deeks 200250--0.86 (0.72, 1.04)0.54 (0.42, 0.71)
Moore 2005510.96 (0.94, 0.98)0.84 (0.81, 0.87)0.86 (0.81, 0.91)0.75 (0.7, 0.8)
Chen, 2008580.96 (0.91, 1.0)0.75 (0.70, 0.80)0.86 (0.73, 1.0)0.45 (0.35, 0.56)

AE = adverse event; CI = confidence interval; COX = cyclooxygenase; GI = gastrointestinal; NSAID = nonsteroidal anti-inflammatory drug; OA = osteoarthritis; RA = rheumatoid arthritis; RR = relative risk

From: Results

Cover of Analgesics for Osteoarthritis
Analgesics for Osteoarthritis: An Update of the 2006 Comparative Effectiveness Review [Internet].
Comparative Effectiveness Reviews, No. 38.
Chou R, McDonagh MS, Nakamoto E, et al.
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