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Agency for Healthcare Research and Quality (US), Rockville (MD)
Chou R, McDonagh MS, Nakamoto E, et al. Analgesics for Osteoarthritis: An Update of the 2006 Comparative Effectiveness Review [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2011 Oct. (Comparative Effectiveness Reviews, No. 38.) Appendix G, Quality Assessment of Trials, Systematic Reviews, and Observational Studies*
| Author, Year | Randomization Adequate? | Allocation Concealment Adequate? | Groups Similar at Baseline? | Eligibility Criteria Specified? | Outcome Assessors Masked? | Care Provider Masked? | Patient Masked? | Reporting of Attrition, Crossovers, Adherence, and Contamination? | Loss to Followup and Attrition: Differential/High? | Intention-to-Treat Analysis? | Quality Rating | Funding |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chan, 2007235 | Yes | Yes | Yes | Yes | Yes | Unclear | Unclear | Yes; Unclear; Yes; Yes | Yes; No | Yes | Fair | Research grant |
| Chan, 2010295 | Yes | Yes | Yes | Yes | No | Yes | Yes | Yes; No; Yes; No | Yes; Yes | Yes | Fair | Pfizer |
| Cheung, 201082 | Yes | Unclear | Yes | Yes | Unclear | Yes | Yes | Yes; No; No; No | No; No | Yes, >95% included in ITT | Fair | Pfizer |
| Dahlberg, 200952 | Yes | Unclear | Yes | Yes | Yes | Yes | Yes | No; No; Yes; No | No; Yes | Yes | Fair | Pfizer |
| Dequeker, 199860 | Unclear | Unclear | Yes | No | Unclear | Unclear | Yes | No; No; No; No | No; No | No | Fair | Boehringer Ingelheim |
| Dickson, 1991298 | Unclear | Unclear | Yes | Yes | Unclear | Yes | Yes | Yes; No; No; No | No; Yes | No | Fair | Pfizer Ltd. |
| Emery, 200853 | Yes | No | No | Yes | Unclear | Yes | Yes | Yes; No; Yes; No | Yes; Yes | No | Fair | Pfizer |
| Feng, 2008116 | Unclear | Unclear | Yes | Yes | Yes | Yes | Yes | No; No; Yes; No | Unclear; Unclear | No | Fair | Chinese Government |
| Furst, 200161 | Unclear | Unclear | Yes | Yes | Unclear | Unclear | Unclear | No; No; No; No | No; No | No | Fair | Boehringer Ingelheim |
| Goldstein, 200088 | Yes | Unclear | Yes | Yes | Unclear | Unclear | Unclear | No; No; No; No | No; No | Yes | Fair | GD Searle; Pfizer |
| Goldstein, 2007254 | Yes | Yes | No | Yes | Yes | Yes | Yes | Yes, No, No, No | Yes, No | No | Fair | TAP pharmaceuticals |
| Goldstein, 2010253 | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes; No; Yes; No | No, Yes | Yes | Fair | AstraZeneca |
| Hawkey, 199663 | Unclear | Unclear | Yes | Yes | Unclear | Unclear | Unclear | No; No; No; No | No; No | Unclear | Fair | NR |
| Herrero-Beaumont, 2007206 | Yes | Yes | Yes | Yes | Unclear | Yes | Yes | Yes; No; Yes; No | No; Yes | Yes | Fair | Rottapharm |
| Hosie, 199664 | Unclear | Unclear | Yes | Yes | Unclear | Unclear | Unclear | No; No; No; No | No; No | Yes | Fair | NR |
| Kahan, 2009209 | Yes | Unclear | Yes | Yes | Yes for radiographs, Unclear for other outcome assessment | Yes | Yes | Yes; No; Yes; No | No; Yes (32% at 2 years) | Yes | Fair | IBSA and Genevrier Laboratories |
| Kosuwon 2010312 | Yes | Unclear | Yes | Yes | Yes | Yes | Yes | Yes; NA; Yes; No | No; No | Yes, >95% included in ITT | Fair | Faculty of Medicine, Khon Kaen University and Bangkok Drug Company |
| Linden, 199666 | Unclear | Unclear | Yes | Yes | Unclear | Unclear | Unclear | No; No; No; No | No; No | No | Fair | NR |
| Mazieres, 2007210 | Yes | Unclear | Yes | Yes | Unclear | Yes | Yes | Yes; No; Yes; No | No; No | Yes | Fair | Pierre Fabre Company |
| McKenna, 1998284 | Unclear | Unclear | Yes | Yes | Unclear | Unclear | Unclear | No; No; No; No | No; No | Yes | Fair | NR (Pharmacia) |
| Messier, 2007213 | Unclear | Unclear | No | Yes | Unclear | Yes | Yes | Yes; No; Yes; No | No; No | Yes | Fair | Rexall Sundown |
| Michel, 2005211 | Yes | Unclear | Yes | Yes | Yes for reading radiographs, Unclear for other outcome assessment | Yes | Yes | Yes; No; Yes; No | No; Yes | Yes | Fair | NR |
| Moller, 2010212 | Yes | Unclear | Yes | Yes | Unclear | Yes | Yes | Chondroitin: 9.4% Placebo: 20% | Yes; No | No | Fair | Bioiberica |
| Rother, 2007299 | Yes | Yes | Yes | Yes | Unclear | Yes | Yes | Yes; Yes; Yes; No | No; No | Yes | Good | IDEA AG and McNeall Consumer and Specialty Pharmaceuticals |
| Rozendaal, 2008207 | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes; No; Yes; No | No; No | Yes | Good | Erasmus Medical Center |
| Sandelin, 1997300 | Unclear | Unclear | Yes | Yes | Unclear | Yes | Yes | Unclear; No; No; No | Unclear; Unclear | Yes | Fair | NR |
| Sawitzke, 2008214 Sawitzke, 2010215 | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes; No; Yes; No | No; No | Yes | Good | NIH |
| Scheiman, 2006261 | Yes | Yes | No | Yes | Yes | Yes | Yes | Yes, No, No, No | Yes, No | Yes | Fair | AstraZeneca |
| Silverstein, 200054 | Yes | Yes | Yes | Yes | Yes | Unclear | Yes | No; No; No; No | No; No | No | Good | Pharmacia |
| Simon, 2009301 | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes; No; No; No | No; No | Yes | Good | Nuvo Research Inc |
| Temple, 2006183 | Yes | No | Yes | Yes | No | Yes | Yes | Yes; No; Yes; No | Yes; Yes | Yes | Fair | McNeil Consumer & Specialty Pharmaceuticals |
| Tiso, 2010302 | Yes | Yes | Yes | Yes | No | No | No | Yes; No; No; No | No; No | Yes | Fair | Helm Pharmaceuticals |
| Tugwell, 2004303 | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes; No; Yes; No | No; No | Yes | Good | Dimethaid Healthcare Ltd. |
| Underwood, 200749 | Yes | Yes | Yes | Yes | No | No | No | Yes; Yes; Yes; Yes | No; Yes | No | Fair | NHS Health Technology Programme |
| Valat, 200167 | Unclear | Unclear | Yes | Yes | Unclear | Unclear | Unclear | No; No; No; No | No; No | Yes | Fair | NR |
| Wilkens, 2010208 | Yes | Yes | Yes | Yes | Unclear | Yes | Yes | Yes; No; Yes; No | No; No | Yes | Good | Norwegian Foundation for Health and Rehabilitation |
| Wojtulewski, 199668 | Unclear | Unclear | Yes | Yes | Unclear | Unclear | Unclear | No; No; No; No | No; No | Yes | Fair | NR |
Quality ratings for the original 2006 CER available at: Chou R, Helfand M, Peterson K, Dana T, Roberts C. Comparative effectiveness and safety of analgesics for osteoarthritis. Comparative Effectiveness Review No.6 (Prepared by the Oregon Evidence-based Practice Center under Contract No. 290-02-0024.). Rockville, MD: Agency for Healthcare Research and Quality, 2006. AHRQ Publication No. 06-EHC009.
NA = not applicable; NR = not reported; NSAID = nonsteroidal antiinflammatory drug; QR = quality result; RA = rheumatoid arthritis
| Author, Year | A Priori Design Provided? | Duplicate Study Selection and Data Extraction? a. Study Selection b. Data Extraction | Comprehensive Literature Search Performed? | Status of Publication Used as an Inclusion Criteria? | List of Studies (Included and Excluded) Provided? | Characteristics of the Included Studies Provided? | Scientific Quality of Included Studies Assessed and Documented? | Scientific Quality of the Included Studies Used Appropriately in Formulating Conclusions? | Methods Used to Combine the Findings of Studies Appropriate? | Likelihood of Publication Bias Assessed? | Conflict of Interest Stated? a. Systematic Review b. Individual Studies | Quality Rating |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Bjordal, 2007197 | Yes | Unclear; Unclear | Yes | Yes | Yes; No | Yes | Yes | Yes | No | Yes; No | Fair | |
| Caldwell, 2006111 | Yes | Yes; Yes | Yes | Yes | Yes; No | Yes | No | No | Yes | Yes | Yes; No | Fair |
| Chen et al., 200858 | Yes | Yes; Yes | Yes | Yes | Yes;Yes | Yes | Yes | Yes | Yes | No | Yes; No | Good |
| Hochberg, 2010199 | Yes | Unclear; Yes | No | Unclear | No | Yes | Yes | Yes | Yes | No | Yes; No | Fair |
| Juni, 2004127 | Yes | Unclear; Yes | Yes | Yes | Yes; No | Yes | Yes | Yes | Yes | Yes | Yes; Yes | Good |
| Kearney et al., 2006121 | Yes | Unclear; Unclear | Yes | Yes | Yes; No | Yes | No | No | Yes | Yes | Yes; No | Fair |
| Lee, 2004179 | Yes | Unclear; Unclear | Yes | Yes | Yes; Yes | Yes | Yes | Yes | Yes | Yes | Yes; Yes | Good |
| Lee, 2010200 | Unclear | Unclear; Unclear | Yes | No | No | Yes | Yes | Unclear | Yes | Yes | No; No | Fair |
| Masso Gonzalez, 201097 | Yes | Unclear; Yes | No | No | Yes; No | Yes | No | No | Yes | No | Yes; No | Fair |
| Moore, 200551 | Yes | Unclear; Unclear | Yes | Yes | Yes; No | No | Yes | No | No | Yes | Yes; Yes | Fair |
| Niculescu, 2009170 | Yes | No; No | No | Yes | No | Yes | Yes | No | Unclear | No | Yes; No | Poor |
| Rostom, 200781 | Yes | Yes; Yes | Yes | Yes | Yes; No | Yes | Yes | Yes | Yes | No | No; No | Fair |
| Rostom, 2002264 | Yes | Yes; Yes | Yes | Yes | Yes; No | No | Yes | Yes | No | Yes | Yes; No | Fair |
| Rubenstein, 2004166 | Yes | Yes; Yes | Yes | Yes | Yes; Yes | Yes | Yes | Yes | NA | No | Yes; No | Good |
| Solomon, 2008114 | Yes | Unclear; Yes | Unclear | Yes | Yes; No | Yes | No | No | No | Yes | Yes; Yes | Fair |
| Soni, 2009165 | Unclear | No; Unclear | No | No | Yes; No | Yes | No | No | Yes | No | Yes; No | Fair |
| Towheed, 2006180 | Yes | Yes; Yes | Yes | Yes | Yes; Yes | Yes | Yes | Yes | Yes | Yes | Yes; Yes | Good |
| Towheed, 200670 | Yes | Yes; Yes | Yes | Yes | Yes; No | Yes | Yes | Yes | Yes | No | Yes; No | Fair |
| Trelle 2011115 | Yes | Yes; Yes | Yes | Yes | Yes; No | Yes | Yes | Yes | Yes | Yes | Yes; No | Good |
| Vlad, 2007201 | Yes | Unclear; Unclear | Yes | Yes | No | No | Yes | Yes | Yes | Yes | Yes; Yes | Good |
| Watson, 200657 | Yes | Unclear; Unclear | No | Yes | Yes; No | Yes | No | No | No | No | Yes; No | Poor |
| Wegman, 2004181 | Yes | Unclear; Unclear | Yes | Yes | Yes; Yes | Yes | Yes | Yes | Yes | No | Yes; No | Fair |
| White, 2003112 | Yes | Unclear; Unclear | No | Yes | Yes; No | No | No | No | No | No | Yes; Yes | Poor |
| White, 2007113 | Yes | Unclear; Yes | No | Yes | Yes; No | No | No | No | No | No | No; No | Poor |
| Zhang, 2004182 | Yes | Unclear; Yes | Yes | Yes | Yes; Yes | No | Yes | Yes | Yes | Yes | Yes; No | Good |
| Zhang, 2006157 | Unclear | Unclear; Yes | Yes | Unclear | Yes; No | Yes | No | Unclear | Yes | Yes | Yes; No | Fair |
RA = rheumatoid arthritis
| Author, Year | Did the Study Attempt to Enroll all (or a Random Sample of) Patients Meeting Inclusion Criteria, or a Random Sample (Inception Cohort)? | Were the Groups Comparable at Baseline on key Prognostic Factors (e.g., by Restriction or Matching)? | Did the Study use Accurate Methods for Ascertaining Exposures, Potential Confounders, and Outcomes? | Were Outcome Assessors and/or Data Analysts Blinded to Treatment? | Did the Article Report Attrition? | Did the Study Perform Appropriate Statistical Analyses on Potential Confounders? | Is There Important Differential Loss to Followup or Overall High Loss to Followup? | Were Outcomes Prespecified and Defined, and Ascertained Using Accurate Methods? | Quality Rating |
|---|---|---|---|---|---|---|---|---|---|
| Cunnington, 2008148 | Yes | No | Yes | Unclear | Unclear | Yes | Unclear | Yes | Fair |
| Fosbol, 2009149 | Yes | No | Unclear | Unclear | Unclear | Yes | Unclear | Yes | Fair |
| Gislason, 2009160 | Yes | No | Yes | Unclear | Yes | Yes | No | Yes | Fair |
| Hudson, 2005161 | Yes | Yes | Yes | Unclear | No | Yes | Unclear | Yes | Fair |
| Ko, 2002257 | Yes | No | Yes | Yes | No | Yes | Unclear | Yes | Fair |
| Kurth, 2003260 | No | Yes | Yes | Yes | Yes | Yes | Unclear | Yes | Fair |
| Mamdani, 2002106 | Yes | No | Yes | Unclear | No | Yes | Unclear | Yes | Fair |
| Mamdani, 2003140 | Yes | Yes | Yes | Unclear | No | Yes | Unclear | Yes | Fair |
| Mamdani, 2004162 | Yes | Yes | Yes | Unclear | No | Yes | Unclear | Yes | Fair |
| Mann, 2004109 | No | N/A | Yes | Unclear | No | No | Unclear | Yes | Fair |
| Mellemkjar, 2002107 | Yes | Unclear | Yes | Unclear | Yes | Unclear | Unclear | Yes | Fair |
| Patel, 2004259 | No | No | Yes | Yes | No | Yes | Unclear | Yes | Fair |
| Rahme & Nedjar, 2007108 Rheumatology | Yes | No | Yes | Unclear | No | Unclear | Unclear | Yes | Fair |
| Rahme, 2007 Arthritis and Rheumatism130 | Yes | No | Yes | Yes | No | Yes | Unclear | Yes | Fair |
| Rahme, 2007130 Pharmacoepidemiology and Drug Safety | Yes | No | Yes | Unclear | No | Unclear | Unclear | Yes | Fair |
| Ray, 2007297 | Yes | No | Yes | Unclear | No | Yes | Unclear | Yes | Fair |
| Ray, 2002142 | Yes | Yes | Yes | Unclear | No | Yes | Unclear | Yes | Fair |
| Solomon, 2008114 | Yes | Yes | Yes | Unclear | No | Yes | Unclear | Yes | Fair |
| Solomon 2010114 | Yes | Yes | Yes | Yes | Yes | Yes | No | Yes | Fair |
| Velentgas, 2006146 | Yes | Yes | Yes | Yes | No | No | Unclear | Yes | Fair |
| Author, Year | Did the Study Attempt to Enroll all or Random Sample of Cases Using Predefined Criteria? | Were the Controls Derived From the Same Population as the Cases? Would They Have Been Selected as Cases if the Outcome was Present? | Were the Groups Comparable at Baseline on key Prognostic Factors (e.g., by Restriction or Matching)? | Did the Study Report the Proportion of Cases and Controls who met Inclusion Criteria That Were Analyzed? | Did the Study use Accurate Methods for Identifying Outcomes? | Did the Study use Accurate Methods for Ascertaining Exposures and Potential Confounders? | Did the Study Perform Appropriate Statistical Analyses on Potential Confounders? | Were Outcomes Prespecified and Defined, and Ascertained Using Accurate Methods? | Quality Rating |
|---|---|---|---|---|---|---|---|---|---|
| Andersohn, 2006132 | Yes | Yes; Yes | Yes | No | Yes | Yes | Yes | Yes | Fair |
| Fischer, 2005133 | Yes | Yes; Yes | No | No | Yes | Yes | Yes | Yes | Fair |
| Garcia-Rodriguez, 2004134 | Yes | Yes; Unclear | Yes | Yes | Yes | Yes | Yes | Yes | Fair |
| Garcia-Rodriguez, 2000237 | Yes | Yes; Yes | No | No | Yes | Yes | Yes | Yes | Fair |
| Garcia-Rodriguez, 200198 | Yes | Yes; Yes | Yes | No | Yes | No | Unclear | Yes | Fair |
| Garcia-Rodriguez, 2007102 | Yes | Yes; Yes | Yes | Yes | Yes | Yes | Yes | Yes | Good |
| Graham, 2005135 | Yes | Yes; Yes | Yes | No | Yes | Yes | Yes | Yes | Fair |
| Helin-Salmivaara, 2006129 | Yes | Yes; Yes | No | No | Yes | Yes | Yes | Yes | Fair |
| Hippisley-Cox, 2005136 | Yes | Yes; Yes | Yes | No | Yes | Yes | Yes | Yes | Fair |
| Johnsen, 2005137 | Yes | Yes; Yes | Yes | No | Yes | Yes | Yes | Yes | Fair |
| Kimmel, 2005138 | Yes | Yes; Yes | No | No | Yes | Yes | Yes | Yes | Fair |
| Lanas, 2006104 | Yes | Yes; Yes | No | Yes | Yes | Yes | Yes | Yes | Good |
| Laporte, 2004105 | Yes | Yes; Yes | Yes | Unclear | Unclear | Yes | Yes | Yes | Fair |
| Levesque, 2005139 | Yes | Yes; Yes | Yes | Yes | Yes | Yes | Yes | Yes | Good |
| Mamdani, 2002140 | Yes | No; No | Yes | Unclear | No | Yes | Unclear | Yes | Fair |
| Mann, 2004109 | No | N/A | Yes | Unclear | No | No | Unclear | Yes | Fair |
| Mellemkjar, 2002107 | Yes | Unclear | Yes | Unclear | Yes | Unclear | Unclear | Yes | Fair |
| Patel, 2004259 | Yes | Yes; Yes | Yes | No | Yes | Yes | Yes | Yes | Fair |
| Rahme&Nedjar, 2007108 | Yes | No; No | Yes | Unclear | No | Unclear | Unclear | Yes | Fair |
| Rahme, 2002141 | Yes | Yes; Yes | Yes | Yes | Yes | Yes | Yes | Yes | Fair |
| Ray, 2007297 | Yes | No; No | Yes | Unclear | No | Yes | Unclear | Yes | Fair |
| Schlienger, 2002143 | Yes | Yes; Yes | Yes | No | Yes | Yes | No | Yes | Fair |
| Solomon, 2002144 | Yes | Yes; Yes | Yes | No | Yes | Yes | Yes | Yes | Fair |
| Solomon, 2004a145 | Yes | Yes; Yes | Unclear | No | Yes | Yes | Yes | Yes | Fair |