| Codons | n | +b+c | +b−c | −b+c | −b−c | G | P |
|---|---|---|---|---|---|---|---|
| Arg | 5 | 36 | 16 | 38 | 106 | 29.1 | 3.4E−08 |
| Tyr | 3 | 12 | 71 | 9 | 179 | 6.7 | 4.8E−03 |
| Ile | 5 | 15 | 25 | 30 | 181 | 10.4 | 6.5E−04 |
| Gln | 3 | 6 | 36 | 6 | 108 | 3.0 | 4.2E−02 |
| Leu | 2 | 16 | 46 | 19 | 78 | 0.8 | 1.8E−01 |
| Phe | 8 | 11 | 74 | 35 | 504 | 3.7 | 2.7E−02 |
| Total | 26 | 96 | 268 | 137 | 1156 | 51.6 | 3.5E−13 |
| Total-Arg | 21 | 60 | 252 | 99 | 1050 | 25.1 | 2.7E−07 |
| Anticodons | # seq | +b+c | +b−c | −b+c | −b−c | G | P |
| Arg | 5 | 20 | 32 | 37 | 107 | 2.9 | 4.5E−02 |
| Tyr | 3 | 18 | 65 | 6 | 182 | 21.7 | 1.6E−06 |
| Ile | 5 | 16 | 24 | 23 | 188 | 17.1 | 1.7E−05 |
| Gln | 3 | 1 | 41 | 17 | 97 | −5.9 | 9.9E−01 |
| Leu | 2 | 27 | 35 | 23 | 74 | 6.7 | 4.7E−03 |
| Phe | 8 | 12 | 73 | 40 | 499 | 3.7 | 2.8E−02 |
| Total | 26 | 94 | 270 | 146 | 1147 | 43.1 | 2.6E−11 |
| Total-Tyr | 21 | 74 | 238 | 109 | 1040 | 39.6 | 1.6E−10 |
| Rev. Codons | # seq | +b+c | +b−c | −b+c | −b−c | G | P |
| Arg | 5 | 16 | 36 | 42 | 102 | 0.05 | 8.3E−01 |
| Tyr | 3 | 3 | 80 | 6 | 182 | 0.03 | 8.6E−01 |
| Ile | 1 | 10 | 30 | 25 | 186 | 4.10 | 4.3E−02 |
| Gln | 3 | 7 | 35 | 11 | 103 | 1.34 | 2.5E−01 |
| Leu | 2 | 12 | 50 | 29 | 68 | −2.22 | 1.4E−01 |
| Phe | 8 | 2 | 83 | 43 | 496 | −4.33 | 3.7E−02 |
| Total | 22 | 50 | 314 | 156 | 1137 | 0.71 | 4.0E−01 |
Column headings: n, number of sequences; +b+c, number of bases both in codons and in binding sites; +b−c, number of bases in binding sites but not in codons; −b+c, number of bases in codons but not in binding sites; −b−c, number of bases neither in codons nor in binding sites; G, the G test for association in a 2 × 2 table, with the Williams correction; P, 1-tailed test for independence with 1 degree of freedom. Values in italics are significant to P < 0.01 after correcting for 6 comparisons. There are significant associations between some amino acid binding sites and both codons and anticodons, even when the single most significant association is removed. However, there is no association at all between amino acid binding sites and the reversed codons.
From: Tests of a Stereochemical Genetic Code
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