Table 3. [X-Linked Hypophosphatemia: Frequency of Select Features]. - GeneReviews®

Feature	% of Persons w/Feature	Comment
Short stature	50%-85%	Percent of persons w/feature is dependent on age, treatment, population, & definition of feature used.
Lower limb bowing	70%-100%
Bone & joint pain	50%-80%	70%-100%
Enthesopathy		70%-100%	Not clinically evident in younger children but develops progressively w/age in all adults, particularly after age 30 yrs
Dental complications	40%-50%	60%-85%	Incidence becomes progressive w/age.
Craniosynostosis	5%-10%		Potentially underrecognized
Need for surgical interventions	40%-50%	60%-95%	Most commonly osteotomies, joint replacement surgery, skull surgery
Fractures		20%-50%	Incl insufficiency & pseudofractures Fractures are not typical in children.
Hearing loss &/or tinnitus	2%-8%	14%-55%	Actual incidence of hearing loss &/or tinnitus may be higher than reported.

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Feature	% of Persons w/Feature		Comment
Feature	Children	Adults	Comment
Short stature	50%-85%		Percent of persons w/feature is dependent on age, treatment, population, & definition of feature used.
Lower limb bowing	70%-100%
Bone & joint pain	50%-80%	70%-100%
Enthesopathy		70%-100%	Not clinically evident in younger children but develops progressively w/age in all adults, particularly after age 30 yrs
Dental complications	40%-50%	60%-85%	Incidence becomes progressive w/age.
Craniosynostosis	5%-10%		Potentially underrecognized
Need for surgical interventions	40%-50%	60%-95%	Most commonly osteotomies, joint replacement surgery, skull surgery
Fractures		20%-50%	Incl insufficiency & pseudofractures Fractures are not typical in children.
Hearing loss &/or tinnitus	2%-8%	14%-55%	Actual incidence of hearing loss &/or tinnitus may be higher than reported.