GRADE profile 14Effectiveness of peritoneal dialysis – mortality – PD (adults)

Quality assessmentSummary of findingsQuality
No of studiesStudy designLimitationsInconsistencyIndirectnessImprecision
PD (adults)
Survival
7
Barraclough 2010
Evans 2010
Fahim 2010
Jarvis 2010
Brown 2009
Siva 2009
Kawanishi 2004		Report from national registryNo serious limitationsNo serious inconsistencySome serious indirectnessaNot assessablebSee appendix 1 for full summary of survival data

Death occurred before the first peritonitis episode in 26.2% (2,243)
Probability of experiencing death before a first peritonitis episode was 29% at 5 yrs using competing risk methods

26 (57%) of people on PD with EPS died
Mortality rate was 42% one year after diagnosis
Median survival from diagnosis 180 days (range 1 to 1075, IQR 61 to 408)

EPS related death
48 PD patients developed EPS during 4 yrs (incidence of 2.5% in 1,958 patients) with an overall mortality rate of 37.5%

Incidence of EPS increased with duration of PD		VERY LOW
a

Studies were not comparative evaluations (downgraded one level).

b

No confidence intervals were reported (downgraded one level).

From: 3, How this guideline was developed

Cover of Peritoneal Dialysis
Peritoneal Dialysis: Peritoneal Dialysis in the Treatment of Stage 5 Chronic Kidney Disease.
NICE Clinical Guidelines, No. 125.
Copyright © 2011, National Institute for Health and Clinical Excellence.

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