Research Findings on Therapies for CPP

Type of TherapyWhat the Research Says
Medicines
  • Gabapentin (brand names: Fanatrex®, Gabarone®, Gralise®, Horizant®, and Neurontin®).
  • Amitriptyline (brand names: Elavil®, Endep®, and Vanatrip®).
  • Botulinum A toxin, commonly known as Botox®, which is given as a shot.
  • There is not enough research to know if any of these medicines help relieve CPP symptoms.
Hormonal Therapies
  • Hormonal contraceptives (birth control), hormone shots, and medicines that act like hormones.
  • There is not enough research to know if any other hormonal therapies help relieve CPP symptoms.
  • In one study, women with endometriosis who took a hormone-like medicine called raloxifene (Evista®) after having a diagnostic laparoscopy had their pain return quicker than women who did not take any medicine.
  • In one study, women who took a hormone-like medicine called depot leuprolide (Lupron Depot®) felt less pain than women who did not take any medicine. Most of the women in the study had endometriosis.
Surgeries
  • Laparoscopic adhesiolysis (pronounced ad-HEES-ee-oh-lye-sis): scar tissue is removed in and around your bowel.
  • LUNA (laparoscopic utero-sacral nerve ablation): some of the nerves in or around your uterus are destroyed.
  • Utero-sacral ligament resection: some of the nerves and tissue around the uterus are removed.
  • Hysterectomy: a surgeon removes all or part of your uterus and ovaries.
  • A few studies showed that removing scar tissue through a laparoscope (called “laproscopic adhesiolysis”) had no effect on relieving pelvic pain or improving the quality of a woman’s life.
  • A few studies showed that LUNA did not help pelvic pain any more than having a diagnostic laparoscopy.
  • There is not enough evidence to know how well utero-sacral ligament resection or hysterectomy work to help relieve CPP symptoms.

From: Treating Chronic Pelvic Pain

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