Table 3.

Comparison of Findings in Persons with Isolated Pituitary Adenomas by Family History and Presence/Absence of a Germline AIP Pathogenic Variant

CharacteristicsFamilial Isolated Pituitary AdenomaSimplex Somatotropinoma 1
AIP-FIPAXLAGFIPA of unknown cause
Clinical features Age of onset 24-24 yrsInfancy / early childhood40 yrs43 yrs
Average # of affected family members 33-412-3NA
Male-to-female ratio 41:1 to 2:11:21:11:1
Adenoma features Somatotropinomas / somatomammotropinomas70%-80%~100%~50%NA
SizeMacroadenomas in vast majorityPituitary hyperplasia-macroadenomaMajority macroadenoma 5Smaller
AggressivenessMoreVariableMoreLess
Response to treatmentPoorerPoorerPoorerBetter

FIPA = familial isolated pituitary adenoma; NA = not applicable

1.

Simplex case = a single occurrence in a family

2.
3.
4.
5.

From: AIP Familial Isolated Pituitary Adenomas

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