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Treadwell J, Mitchell M, Eatmon K, et al. Imaging Tests for the Diagnosis and Staging of Pancreatic Adenocarcinoma [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2014 Sep. (Comparative Effectiveness Review, No. 141.)
Imaging Tests for the Diagnosis and Staging of Pancreatic Adenocarcinoma [Internet].
Show detailsSome comparative accuracy studies reported data separately for different readers. Our primary analyses discussed in the main report only used data from reader 1 for each such study. This appendix contains the results of sensitivity analysis of this choice, for two meta-analyses:
Sensitivity Analysis of MDCT vs. MRI for Diagnosis
The primary analysis yielded estimates for MDCT of 89% for sensitivity and 90% for specificity, whereas the estimates for MRI were 89% for sensitivity and 89% for specificity. The table below lists the results of the 35 sensitivity analyses; all analysis provided estimates that were very similar to the primary analysis.
Table E-1Sensitivity analysis of MDCT vs. MRI for diagnosis
| Which Readers were Used for the Four Studies Reporting Multiple Readers Separately | MDCT Sensitivity | MDCT Specificity | MRI Sensitivity | MRI Specificity |
|---|---|---|---|---|
| 1,1,1,1 (primary analysis) | 89% (95% CI: 82% to 94%) | 90% (95% CI: 80% to 95%) | 89% (95% CI: 81% to 94%) | 89% (95% CI: 74% to 95%) |
| 1,1,1,2 | 89% (95% CI: 83% to 94%) | 90% (95% CI: 81% to 95%) | 89% (95% CI: 80% to 94%) | 88% (95% CI: 75% to 94%) |
| 1,1,1,3 | 89% (95% CI: 83% to 94%) | 90% (95% CI: 81% to 95%) | 89% (95% CI: 81% to 94%) | 89% (95% CI: 74% to 95%) |
| 1,1,2,1 | No convergence | No convergence | 88% (95% CI: 80% to 93%) | 90% (95% CI: 75% to 96%) |
| 1,1,2,2 | No convergence | No convergence | 88% (95% CI: 80% to 93%) | 89% (95% CI: 75% to 95%) |
| 1,1,2,3 | No convergence | No convergence | 88% (95% CI: 80% to 93%) | 90% (95% CI: 75% to 96%) |
| 1,2,1,1 | 90% (95% CI: 82% to 94%) | 90% (95% CI: 80% to 95%) | 90% (95% CI: 80% to 95%) | 89% (95% CI: 75% to 95%) |
| 1,2,1,2 | 90% (95% CI: 83% to 94%) | 90% (95% CI: 81% to 95%) | 90% (95% CI: 80% to 95%) | 88% (95% CI: 75% to 94%) |
| 1,2,1,3 | 90% (95% CI: 83% to 94%) | 90% (95% CI: 81% to 95%) | 90% (95% CI: 80% to 95%) | 89% (95% CI: 75% to 95%) |
| 1,2,2,1 | 89% (95% CI: 82% to 93%) | 90% (95% CI: 80% to 95%) | 89% (95% CI: 80% to 94%) | 90% (95% CI: 75% to 96%) |
| 1,2,2,2 | 89% (95% CI: 82% to 93%) | 90% (95% CI: 81% to 95%) | 89% (95% CI: 79% to 94%) | 89% (95% CI: 75% to 95%) |
| 1,2,2,3 | 89% (95% CI: 82% to 93%) | 90% (95% CI: 81% to 95%) | 89% (95% CI: 80% to 94%) | 90% (95% CI: 75% to 96%) |
| 1,3,1,1 | 90% (95% CI: 82% to 94%) | 90% (95% CI: 80% to 95%) | 90% (95% CI: 80% to 95%) | 89% (95% CI: 75% to 95%) |
| 1,3,1,2 | 90% (95% CI: 83% to 94%) | 90% (95% CI: 81% to 95%) | 90% (95% CI: 80% to 95%) | 88% (95% CI: 75% to 94%) |
| 1,3,1,3 | 90% (95% CI: 83% to 94%) | 90% (95% CI: 81% to 95%) | 90% (95% CI: 80% to 95%) | 89% (95% CI: 75% to 95%) |
| 1,3,2,1 | 89% (95% CI: 82% to 93%) | 90% (95% CI: 80% to 95%) | 89% (95% CI: 80% to 94%) | 90% (95% CI: 75% to 96%) |
| 1,3,2,2 | 89% (95% CI: 82% to 93%) | 90% (95% CI: 81% to 95%) | 89% (95% CI: 79% to 94%) | 89% (95% CI: 75% to 95%) |
| 1,3,2,3 | 89% (95% CI: 82% to 93%) | 90% (95% CI: 81% to 95%) | 89% (95% CI: 80% to 94%) | 90% (95% CI: 75% to 96%) |
| 2,1,1,1 | 91% (95% CI: 84% to 95%) | 89% (95% CI: 80% to 95%) | 91% (95% CI: 82% to 95%) | 89% (95% CI: 77% to 95%) |
| 2,1,1,2 | 91% (95% CI: 84% to 95%) | 90% (95% CI: 81% to 95%) | 90% (95% CI: 81% to 95%) | 88% (95% CI: 78% to 94%) |
| 2,1,1,3 | 91% (95% CI: 84% to 95%) | 90% (95% CI: 81% to 95%) | 91% (95% CI: 82% to 95%) | 89% (95% CI: 77% to 95%) |
| 2,1,2,1 | 90% (95% CI: 84% to 94%) | 89% (95% CI: 79% to 94%) | 90% (95% CI: 81% to 94%) | 90% (95% CI: 78% to 96%) |
| 2,1,2,2 | No convergence | No convergence | 89% (95% CI: 81% to 94%) | 89% (95% CI: 78% to 95%) |
| 2,1,2,3 | No convergence | No convergence | 90% (95% CI: 81% to 94%) | 90% (95% CI: 78% to 96%) |
| 2,2,1,1 | 92% (95% CI: 84% to 96%) | 89% (95% CI: 80% to 95%) | 92% (95% CI: 82% to 96%) | 89% (95% CI: 78% to 95%) |
| 2,2,1,2 | 92% (95% CI: 84% to 96%) | 90% (95% CI: 81% to 95%) | 91% (95% CI: 81% to 96%) | 88% (95% CI: 78% to 94%) |
| 2,2,1,3 | 92% (95% CI: 84% to 96%) | 90% (95% CI: 81% to 95%) | 92% (95% CI: 82% to 96%) | 89% (95% CI: 78% to 95%) |
| 2,2,2,1 | 90% (95% CI: 84% to 94%) | 89% (95% CI: 80% to 94%) | 90% (95% CI: 81% to 95%) | 90% (95% CI: 78% to 96%) |
| 2,2,2,2 | 90% (95% CI: 84% to 94%) | 90% (95% CI: 80% to 95%) | 90% (95% CI: 81% to 95%) | 89% (95% CI: 78% to 95%) |
| 2,2,2,3 | 90% (95% CI: 84% to 94%) | 90% (95% CI: 80% to 95%) | 90% (95% CI: 81% to 95%) | 90% (95% CI: 78% to 96%) |
| 2,3,1,1 | 92% (95% CI: 84% to 96%) | 89% (95% CI: 80% to 95%) | 92% (95% CI: 82% to 96%) | 89% (95% CI: 78% to 95%) |
| 2,3,1,2 | 92% (95% CI: 84% to 96%) | 90% (95% CI: 81% to 95%) | 91% (95% CI: 81% to 96%) | 88% (95% CI: 78% to 94%) |
| 2,3,1,3 | 92% (95% CI: 84% to 96%) | 90% (95% CI: 81% to 95%) | 92% (95% CI: 82% to 96%) | 89% (95% CI: 78% to 95%) |
| 2,3,2,1 | 90% (95% CI: 84% to 94%) | 89% (95% CI: 80% to 94%) | 90% (95% CI: 81% to 95%) | 90% (95% CI: 78% to 96%) |
| 2,3,2,2 | 90% (95% CI: 84% to 94%) | 90% (95% CI: 80% to 95%) | 90% (95% CI: 81% to 95%) | 89% (95% CI: 78% to 95%) |
| 2,3,2,3 | 90% (95% CI: 84% to 94%) | 90% (95% CI: 80% to 95%) | 90% (95% CI: 81% to 95%) | 90% (95% CI: 78% to 96%) |
Note: “No convergence” means that the metandi command in stata did not converge on estimates, even after increasing the number of integration points to the maximum of 15.
Sensitivity Analysis of MDCT vs. MRI for Assessment of Metastases
The primary analysis yielded estimates for MDCT of 48% for sensitivity and 90% for specificity, whereas the estimates for MRI were 50% for sensitivity and 95% for specificity. The table below lists the results of the two sensitivity analyses; both provided estimates that were very similar to the primary analysis.
Table E-2Sensitivity analysis of MDCT vs. MRI for assessment of metastases
| Which Reader was Used for the One Study Reporting Multiple Readers Separately | MDCT Sensitivity | MDCT Specificity | MRI Sensitivity | MRI Specificity |
|---|---|---|---|---|
| 1 (primary analysis) | 48% (95% CI: 31% to 66%) | 90% (95% CI: 81% to 95%) | 50% (95% CI: 19% to 81%) | 95% (95% CI: 91% to 98%) |
| 2 | 48% (95% CI: 31% to 65%) | 91% (95% CI: 81% to 96%) | 54% (95% CI: 18% to 86%) | 96% (95% CI: 93% to 98%) |
| 3 | 48% (95% CI: 31% to 65%) | 91% (95% CI: 81% to 96%) | 54% (95% CI: 18% to 86%) | 96% (95% CI: 93% to 98%) |
Sensitivity Analysis of MDCT vs. MRI for Assessment of Metastases
The primary analysis yielded estimates for MDCT of 48% for sensitivity and 90% for specificity, whereas the estimates for MRI were 50% for sensitivity and 95% for specificity. The table below lists the results of the two sensitivity analyses; both provided estimates that were very similar to the primary analysis.
Table E-3Sensitivity analysis of MDCT vs. MRI for assessment of metastases
| Which Reader was Used for the Two Study Reporting Multiple Readers Separately | MDCT Sensitivity | MDCT Specificity | MRI Sensitivity | MRI Specificity |
|---|---|---|---|---|
| 1,1 (primary analysis) | 48% (95% CI: 31% to 66%) | 90% (95% CI: 81% to 95%) | 50% (95% CI: 19% to 81%) | 95% (95% CI: 91% to 98%) |
| 2 | 48% (95% CI: 31% to 65%) | 91% (95% CI: 81% to 96%) | 54% (95% CI: 18% to 86%) | 96% (95% CI: 93% to 98%) |
| 3 | 48% (95% CI: 31% to 65%) | 91% (95% CI: 81% to 96%) | 54% (95% CI: 18% to 86%) | 96% (95% CI: 93% to 98%) |
- Sensitivity Analyses for Meta-Analyses Involving Multiple Readers per Study - Im...Sensitivity Analyses for Meta-Analyses Involving Multiple Readers per Study - Imaging Tests for the Diagnosis and Staging of Pancreatic Adenocarcinoma
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