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Herepath A, Kitchener M, Waring J. A realist analysis of hospital patient safety in Wales: applied learning for alternative contexts from a multisite case study. Southampton (UK): NIHR Journals Library; 2015 Sep. (Health Services and Delivery Research, No. 3.40.)

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A realist analysis of hospital patient safety in Wales: applied learning for alternative contexts from a multisite case study.

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Chapter 8Reducing Health-care-Associated Infection

Overview

In this chapter we examine RHAI, the final focal intervention drawn from the 1000 Lives+ programme. Our attention was directed to two aspects of this patient safety intervention: (1) hand hygiene and (2) the appropriate use of antimicrobial drugs. Importantly, in contrast to the other focal interventions selected from the 1000 Lives+ national programme, set out in Chapters 6 and 7, such interventions do not represent practice innovations. Instead, they represent the consolidation of established best practice. We begin with a brief overview of the RHAI, defining its multicomponent structure, aim and drivers. This we augment with a review of health-care-associated IPAC, highlighting key issues and the challenges that confront developed health-care systems.

Second, we undertake a realist analysis of the institutionalisation of RHAI in Wales, as illustrated by our comparative case study of sites A, B, C and D. We explain the structural conditioning, sociocultural interaction and structural elaboration or reproduction fostered through the actions of three groups of key actors: consultant microbiologists, IPAC nurses and pharmacists specialising in antibiotics medicines management. We concentrate on these three groups because they are directly involved in the operation of RHAI under the 1000 Lives+ programme, but we also include in our analysis the perceptions of a wide range of health-care professionals. Finally, informed by the findings of our realist analysis, we set out our understanding of the RHAI I-CMAO configuration.

Focal intervention, aim and drivers

Reducing Health-care-Associated Infection, the last of the three focal interventions considered in this study, aims to support health-care staff to reduce the overall burden of nosocomial (hospital-acquired) infection in NHS Wales. As illustrated in Figure 21, RHAI comprises four interventions to prevent the transmission of infection, two of which are aligned to promote the effective treatment of infection, and a further three interventions to facilitate patient involvement in their care. During the period of this study RHAI was augmented with further advice on the appropriate and timely use of invasive devices, specifically guidance aimed to reduce peripheral venous cannula (PVC) and catheter-associated urinary tract infections (CAUTI). This extension was beyond the scope of our research protocol and ethics submissions, and so our research focused on standard precautions for hand hygiene to prevent the transmission of infection and the appropriate use of antimicrobial drugs to ensure the effective prevention and treatment of infection. Nonetheless, the publicity surrounding the launch and implementation of the PVC and CAUTI interventions impacted on the context of care.

FIGURE 21. Driver diagram: RHAI.

FIGURE 21

Driver diagram: RHAI.

Figure 21: key point summary

Figure 21 depicts the driver diagram for the focal intervention: RHAI. Attention is directed to two of the four aspects of this patient safety intervention which are focused at clinical and other staff, as defined below:

  • point 1, standard precautions for hand hygiene to prevent the transmission of infection and
  • point 2, appropriate use of antimicrobial drugs to ensure the effective prevention and treatment of infection.

To aid our understanding of the interplay of context and mechanism in the operationalisation of this focal intervention, the perspectives of consultant microbiologists, IPAC nurses and pharmacists specialising in antibiotics medicines management, each directly involved in the operationalisation of the RHAI under the auspices of the 1000 Lives+ national programme, enrich our analysis.

In contrast to the other focal interventions selected from the 1000 Lives+ national programme, standard precautions for hand hygiene and the appropriate use of antimicrobial drugs do not represent practice innovations but are merely the consolidation of established best practice.

Health-care-associated infection, prevention and control

Health-care-associated infection (HCAI), prevention and control is an issue that impacts on developed and developing health-care systems.572574 It is a source of concern for politicians, health-care professionals, patients and the public alike.575,576 Addressing the human costs in terms of morbidity and mortality is paramount,577,578 but there is also a need to minimise the cost burden incurred through protracted treatment and extended lengths of stay.577,579582 A range of patient safety interventions have been designed to improve this problem.181,583590 Such interventions typically encompass (i) mandatory reporting and surveillance programmes;591594 (ii) ensuing targets, standards and performance indicators for IPAC,595620 especially for high-risk clinical practices600602 and vulnerable patient groups;603606 and (iii) heightened control over the use of antimicrobial drugs in the face of the changing epidemiology of HCAIs,589,607610 exemplified by the rise of MRSA and extended-spectrum beta-lactamase (ESBL)-producing strains of Escherichia coli and Klebsiella pneumonia.609,611619

In the NHS, following major outbreaks of hospital-acquired (nosocomial) infection,620 national targets for the reduction of MRSA bacteremias (blood infections) and C. difficile (gastrointestinal) infection are supported by enhanced mandatory surveillance. Oversight rests with the Health Protection Agency in England and Scotland,592,597,621 and, in Wales, the WHAIP led by Public Health Wales. In this manner, IPAC is placed at the centre of clinical and corporate governance.622 Indeed, the Health Act 2006 Code of Practice mandates adherence to national and local policies and protocols.623 Zero tolerance of HCAIs624,625 is a primary policy goal.

Core to success is the enactment of good hand hygiene across health-care practitioners, support workers626630 and patients.631635 This standard precaution, perceived to be fundamental to safe health-care practice,636 is captured through the WHO’s ‘five moments of hand hygiene’.637 These guidelines harness a substantial evidence base in support of hand antisepsis to limit the incidence of HCAIs.587 However, such education requires regular updating638640 to promote the adoption of, and continued adherence to, evidence-based improvements,641,642 and monitoring systems are necessary to audit compliance.595,596,643645

Although existing studies highlight success in limiting HCAIs48,181 through hand hygiene195,639,646648 and wider reaching educational programmes,649653 a high level of non-compliance with basic infection control measures persists among health-care professionals.654 Indeed, junior medical and nursing staff copy the aberrant behaviour of their superiors,655657 which results in the entrenchment of non-compliance across successive generations.655660 IPAC teams, therefore, have a central role to play in active staff engagement,661 support for peer-to-peer education,662 and the monitoring of HCAIs to reduce the burden of avoidable harm to patients and its associated untoward costs.581,663689

The changing epidemiology of HCAIs607,608,611,612,617,666694 also places demands on medical microbiologists and clinical pharmacists specialising in antibiotic medicines management.57,671 Collectively, their active stewardship of antibiotic prescribing is acknowledged to limit overprescribing672 and improve adherence to guidelines.673676 However, their oversight of surgical prophylaxis is constrained by the charting and timing of the administration of such drugs within the theatre environment.677679

There are many other ways in which patients may acquire infections while in hospital. These include the use of invasive medical devices such as ventilators,48,680710 intravenous and arterial cannulae605,687690 and various sorts of catheter691695 However, these sources of infection and the precautions taken to avoid them are not considered in this study.

Realist analysis and comparative case study

We now undertake a critical realist analysis of the institutionalisation of the 1000 Lives+ programme’s RHAI. Again, our case study considers sites A, B, C and D. Our analysis focuses on three groups of key actors: consultant microbiologists, IPAC nurses and pharmacists specialising in antibiotics medicines management. Each is directly involved in the operation of RHAI under the auspices of the 1000 Lives+ national programme. However, as HCAIs are an issue for all to address, we include the perceptions of a wide range of health-care professionals in our analysis.

As in the two previous chapters, we consider the focal intervention in context and explore the dominant structural and cultural emergent properties impacting key actors involved in the operation of the RHAI. Next, to reveal the generative mechanisms in play, we examine mediation via first- and second-order emergents and the resultant situational logic. Then, to examine the initiation of change, we explore the unfolding strategic negotiation of change and the mode of institutional work enacted. Finally, we reflect on the nature of any sustained outcome, be that elaborative or reproductive, that occurred following the implementation of RHAI. This analysis forms the foundation of our refinement of the I-CMAO configuration spanning the Welsh health-care field in 1000 Lives+ institutionalisation: RHAI – local implementation of the focal intervention and contribution to I–CMAO configuration spanning the Welsh health-care field.

Structural conditioning: structural and cultural emergent properties in the Welsh health-care field

In contrast to the other focal interventions selected from the 1000 Lives+ programme and analysed in Chapters 6 and 7, the discrete interventions selected from RHAI – standard precautions for hand hygiene to prevent the transmission of infection and the use of antimicrobial drugs to ensure the effective prevention and treatment of infection – did not represent practice innovations. The dominant structural emergent properties impacting the RHAI were, therefore, the complex array of established alternative frameworks and the ongoing surveillance of their effectiveness via the WHAIP (transcription 8:01, below).

The question for me is, how do we untangle 1000 Lives+ from all of the other elements in play – it’s complicated, confounded – because what’s happening is happening between 1000 Lives+, all of the other frameworks and antimicrobial guidelines that are out there, and mandatory surveillance reporting and feedback via WHAIP.

So, it’s through one or a combination of all of those things that the higher echelons, if you like, of hospital management are now faced with infection control, and its importance, much more so than they were 10 years or so ago, or even less than that. So I think, whether it’s due to 1000 Lives+, other frameworks, or the surveillance processes in place, I think it’s achieving something – because they have to be aware and address HCAI due to WHAIP reporting to the Welsh Government – my impression is that they are aware of it and they feel accountability.

Now when you have accountability in the higher levels of management, the way that they effect that accountability, quite rightly, is through delegation and spreading the message in terms of what needs doing. The previous medical director here, who was spectacularly engaged, even before 1000 Lives+, with the idea of infection control provided a real sense of leadership, and had an awful lot of insight. I don’t know why that was, perhaps he just saw it as part of his role, I don’t know, but he did it very well. But now, now that we’re a lot bigger, and we have a wider range of – I don’t want to use that term ‘lower’ – some of the next tier down levels of management, like director level and their associates or assistants, that message is dissipated.

Consultant microbiologist, case site C1 (034); transcription 8:01

Other structural issues also surfaced during discussions with respondents, notably the compounding impact of the reconfiguration of NHS Wales on framework alignment, and the need for the co-ordination and consolidation of different guidelines under a health-board-wide and emergent all-Wales remit (transcriptions 8:02 and 8:03, below).

The reconfiguration of NHS Wales, the formation of health boards that’s occurred during the roll-out of the original 1000 Lives campaign and 1000 Lives+, I think this has created issues which are problematic. I think that the creation of much larger health boards has created barriers to the roll-out of 1000 Lives and 1000 Lives+. So, for example, something that’s seen to be an incredibly high priority within this health board, quite rightly, is the fact that before we were [number] Trusts, and we all had, I imagine, a pretty good spread of infection control policies that were broadly in line, and in their own way ticked the boxes for national recommendations. But they were not the same. Now a priority, here, is that we have harmonised consistent policies. So, you know, we all have workable policies that we could just leave alone to would work on each site; but no, we are required to have single harmonised policies that we all agree to. Now the differences that existed were there for a reason. But now we’ve got to try and overcome those differences, agree amongst ourselves, and then get wider agreement across the consultants. And the point being that that’s a job of work that takes time and is outside the time requirements that might be put into 1000 Lives+.

Consultant microbiologist, case site A1 (035); transcription 8:02

Working with consultant microbiologists, we produce and review the antibiotic policies used across the health board. There’re planning to have all Wales antibiotic policy guidelines. [Have they been produced and published?] No, no way: it’s still at a very early stage of discussion, about 6 months in, and I think it will take years to agree: there’s so much disagreement about what to use, when, and some doctors simply refuse to follow any guidelines, no matter who produces them: ‘where’s the evidence; the evidence is disputed; it’s not that clear cut; it’s my freedom to prescribe how I see fit for my patient’. We get that same old argument, from some of them, all the time.

So, we produce the health board’s antibiotic guidelines and monitor them through audit cycles across each ward or base hospital; we do the education associated with antibiotic usage for the junior doctors, nurses, and other staff, including other pharmacists; and we do antibiotic ward rounds with consultant microbiologists – this is a small hospital, so consultant microbiologists don’t have junior doctors attached to them, so, in a way, we act like their juniors – this involves antibiotic prescribing and follow-up, checking that the drug and indication are appropriate, that the dose, route, are all correct, that sort of stuff. I don’t think of the context outside so much, I suppose; for me, it’s about the people I talk to and work with each day.

Pharmacist, Antibiotics Medicines Management, case site B2 (001); transcription 8:03

In addition to the structural constraints arising from various existing guidelines, a previous patient safety improvement programme, the Safer Patients Initiative, had a legacy effect which resonated strongly with some IPAC nurses interviewed as part of this study (transcription 8:04, below, and transcription 8:05).

If I’m honest with you, when it [1000 Lives] came out originally, it was a bit of a spin-off from the SPI [Safer Patients Initiative], you know, the IHI approach, wasn’t it?

It came out at the time when we were reorganising the health service in Wales. So, I think, a lot of the correspondence went to people whose positions have changed and so on and so forth. They started off at a very high level but there was a lot going on in the organisations and it didn’t really filter down – the leadership was a little bit fragmented at that time – I think in the last 2 years we’ve sort of taken hold of it.

We were a little bit at odds with the priorities of the RHAI programme initially because we had done our own prevalence survey, internally, and we hadn’t identified problems with catheter-associated UTIs [urinary tract infections]. We did an incident survey over a period of 1 month in wards in the organisation and there were no issues with catheter-associated infections at that point in time. However, we identified problems with peripheral venous cannulas during our point prevalence survey. But the campaign was mandating a focus on short-term urinary catheters, whereas our priority at that time was more to do with peripheral lines. So it was a little bit of, it was a little bit, you know, sort of didactic I guess: ‘this is a priority, and this is what you must do’, and I was thinking, well, in our organisation, this is our priority and we will do that, at the moment we need to focus on that.

Senior nurse, IPAC, case site A2 (076); transcription 8:04

Such structural constraints were interwoven with the current financial challenge; as one respondent commented, ‘the biscuits are gone!’ (transcriptions 8:06 and 8:07).

The cultural emergent properties impacting staff involved with infection control arose from their different but interlocking roles. It was clear that there was close liaison between each professional group (transcriptions 8:08 and 8:09, below).

I’m aware that there are different models, if you like, with the consultant leading, consultant microbiologist, the infection control doctor leading the service. Here it’s a flat model – a flat model between the lead infection control nurse and the lead infection control doctor – and it is something that I feel not only works well but is appropriate because we bring different skills to the mix, and I’m not sure that any set of skills is more important than the other.

Consultant microbiologist, case site C1 (T034); transcription 8:08

Well, predominantly, in infection control, our role is for support and advice to staff. That’s our role. But we’re also involved in conducting audits – particularly things like hand hygiene audits, commode audits, environmental audits, and those kind of things – and those are fed back to ward staff, the results and an required action. But we also carry out things like surveillance, so we’ll monitor our alert organisms [for WHAIP]. If there’s any kind of change – an indication that there’s an increase in health-care-associated infections, or an increase in any of our WHAIP alert organism, such as MRSA, MSSA [meticillin-sensitive S. aureus], C. diff, Group A strep [Group A Streptococcus], E. coli, any of the alert organisms, we’ll go and find out, and liaise with the consultant microbiologist.

Senior nurse, IPAC, case site D2 (017); transcription 8:09

Such liaison also gave rise to professional networks which enabled processes of interprofessional knowledge mobilisation that were perceived to be operating at a more challenging level than those of 1000 Lives+ (transcription 8:10, below).

If I’m facing something that new, a bit different to what I’ve handled before, I would first contact other antibiotic specialist pharmacists – there’s a network across Wales – so that would be one source of information and advice. The others, naturally, are the consultant microbiologists and IPAC nurses. Also, there’s a formal meeting twice a year of the Antibiotic Stewardship Forum, which consists of medical microbiologists, pharmacists, and some specialist nurses. They don’t meet that often but they’re a great source of information, and an opportunity to share learning and development.

[Are there any other groups that you would contact for advice or support?] Yes, the UK CPA [UK Clinical Pharmacy Association] is another source of information. They have an infection management group – they’re more advanced in England – there’s a good web site, support materials, that sort of stuff which is very helpful. In England, they have developed the consultant pharmacists role – we don’t have those in Wales yet; but I think one is due to be developed in Renal Pharmacy, which is an incredibly complex field. So that sort of recognition, legitimacy almost, is absent in Wales. Another group is the British Society for Antimicrobial Chemotherapy. They’ve got a useful website, and they run all Wales study days, which, in terms of the evidence and focus, are pitched at a far higher level than 1000 Lives+. I feel like I’m learning something new when I attend these, not just being told to wash my hands before I go onto a ward, or to make sure that a course of antibiotics has a defined stop date! Another is the Welsh Microbiological Association and again, they run study days, really focused on education, and this is linked into Public Health Wales. So this is all at a level above 1000 Lives+.

Pharmacist, Antibiotics Medicines Management, case site B2 (001); transcription 8:10

First-order emergents for key actors central to the institutionalisation of Reducing Health-care Associated Infection

Such structural and cultural emergent properties shaped the context in which key actors, central to the institutionalisation of the RHAI now found themselves and conditioned their ensuing actions. We therefore asked consultant microbiologists, nurses specialising in IPAC and pharmacists specialising in the management of antibiotic medicines to reflect on their placement, their vested interests and the perceived opportunity costs associated with various courses of action, to determine how this shaped their activities.

Consultant microbiologists

The vested interests of consultant microbiologists lay in the day-to-day operational management of IPAC, centred on the provision of their expert advice, and the ongoing demands which arose from WHAIP surveillance (transcriptions 8:11 to 8:13). The 1000 Lives+ national programme and RHAI, though aligned to such tasks, were a secondary consideration (transcription 8:12, below).

Well, of course, a lot of the mandatory reporting used to be done manually by microbiologists – that used to take up our time, particularly statistics for bacteraemia – but that’s all done centrally now. So all that information is sucked out of the data store in Wales.

In terms of mandatory requirements, there’s, in theory, there’s less for us to do. But I strongly suspect that – I’m not alone here, in fact I guarantee you that all microbiologists who used to do it, still do it – because there is an expectation that, a requirement for us, when reports are generated centrally through WHAIP before those reports come out as you know the raw data is circulated back to us to check if we think it’s correct but we would only know that if we were doing the same data collection that we ever did!

But we would want to do it anyway – not just to check the accuracy of WHAIP reports, bearing in mind that some of those reports are somewhat retrospective – because if we relied on them to find out if we were having an out of the ordinary rise in numbers of C. diffs in a given area or MRSA bacteraemia associated with line use in a certain area, we’d miss the boat and problems would have deteriorated. So we have, we need to do these things, relatively, real time. So that’s one form of reporting pressure if you like. I mean we see it as part of our work – as our normal role – and that’s why I’m fairly confident that it doesn’t matter who you ask in Wales they’ll probably give you that exact same answer. But nonetheless it’s a time pressure that needs, a role that needs to be fulfilled.

On top of that you’ve then got two other pressures. So, one is the one I’ve just mentioned, whereby you’re noticing your own local priorities with these figures that you’re generating for WHAIP, so that we can focus our attention and look at the interventions that should be being made, and audit whether they are being made, and how well they’re being done and that kind of thing. But at the same time we might be receiving instructions that we should be looking at other areas – and it’s not that those areas aren’t important – but then our time is split because there’s the thing that we see, that we feel we have an immediate need, and then there’s the requirement to fit in with 1000 Lives+ I suppose.

Consultant microbiologist, case site B1 (036); transcription 8:12

In focusing on the broader remit of IPAC, as opposed to the progressive institutionalisation of RHAI, consultant microbiologists operated under a professional (medical) logic co-existent with and complementary to professional (health-care management) and bureaucratic state logics. Thus, the RHAI was absorbed and integrated into existing and culturally entrenched monitoring processes. This aided its adoption and reproduction across NHS Wales’ health boards.

Infection prevention and control nurses

The vested interests of IPAC nurses at each case site, captured in transcriptions 8:14 to 8:21, again reflected the impact of their traditional role jurisdictions. These overshadowed and pre-dated the 1000 Lives+ national programme and RHAI (transcriptions 8:14 and 8:15, below).

We do all the audits – environmental audits, hand hygiene audits – ward-based teaching, like the session that you’re going to see this afternoon, and just general support for the wards, and where we find a problem, we like to go back and offer a solution and support the staff to eradicate hospital-acquired infections.

Nurse, IPAC, case site A2 (003); transcription 8:14

We were doing all this before 1000 Lives and 1000 Lives+ – including looking at urinary catheter-associated infections and peripheral and central line infections – so the interventions 1000 Lives+ promotes are already integrated into our monitoring systems, and it would be the same for all health boards.

Senior nurse, IPAC, case site A2 (002); transcription 8:15

In addition, some aspects of infection control lay far beyond the scope of RHAI (transcription 8:17, below).

It is unacceptable to have a case of Clostridium difficile, and if you have two within a 28-day period, a formal meeting is called. [What do you do if you have a persistent problem with Clostridium difficle?] If there was a continuing problem, then we’d look to Bioquel the ward – bio-bomb it with hydrogen peroxide – they go in, in their decontamination suits, and close the doors. They do it one section at a time, they vapour blast it with hydrogen peroxide, they leave all the equipment in there, all the beds, everything stays in there, so there’s no risk of us missing something really. After that the domestic staff will go in and just clean – soap and water, detergent – and then we put the patients back in the ward. So far, that seems to be very effective. But we’ll only do that if we have real hotspots.

Nurse, IPAC, case site B1 (131); transcription 8:17

The newer 1000 Lives+ interventions associated with RHAI, though beyond the scope of this study, were an extension of established practice. However, owing to medical resistance, some specified changes were a source of concern (transcription 8:18, below).

The new 1000 Lives+ intervention was launched nationally last year, and we’ve been rolling out the PVC bundle but we have the catheter bundle in place for about 4 years now. The PVC bundle has proved a little more difficult to implement really, in that there’s been a change to practice, there’s also been a lot of medical opposition. [Why?] Because they’ve got to do stuff! What they’re saying is: ‘where’s the evidence to say that they’re not doing things properly, and that we’ve got a high rate of infection? Why should I change my practice without the evidence that there’s a problem in the first place?’ [They don’t perceive a problem in their current practice or the rates of infection?] Because they don’t believe they’ve got a problem. They don’t believe that by changing practice, or being forced to evidence that they’re doing what they should be doing, that that will make any difference. And, in one respect, you could sort of see their point, in that there is a low rate of peripheral venous infections. But we do get catheter-related bloodstream infections and the incidence of MSSAs [meticillin-sensitive S. aureus] within the health board has been increasing. But what we asking them to do, due to 1000 Lives+, well, for them, it just takes too long.

Nurse, IPAC, case site C1 (132); transcription 8:18

In regards to 1000 Lives+, I’d say the introduction of the bundles and the STOP campaign is probably all the infection control team have been involved with and some of that just involved minor changes to our practice.

Nurse, IPAC, case site D2 (019); transcription 8:21

In focusing their agential activity on the broader remit of IPAC, in addition to the institutionalisation of the RHAI, specialist nurses operated under a professional (nursing) logic that was complementary to professional (health-care management) and bureaucratic state logics.

Antibiotic medicines management pharmacists

Transcriptions 8:22 to 8:29 suggest that the vested interests of pharmacists with expertise in antibiotic medicines management were poorly aligned to RHAI, which they saw as irrelevant given their level of expertise (transcriptions 8:24 and 8:25, below).

[When you think about the knowledge and information that you use within you role, do you draw on the 1000 Lives+ resources?] No, I don’t use them. There’s little information in them that relevant to me; I mean, it’s just so basic – really bottom-end stuff, basic, mundane – if you don’t know it, you shouldn’t be working as a clinical pharmacist.

1000 Lives+ is, it’s too basic, directed at lower-level nurses. For me, it offers little. [Do you use the driver diagrams?] No, they’re not relevant: they’re basic. I do a ward round with a consultant microbiologist each day and there’s more to that than hand washing! The diagrams aren’t education. I mean, we are using the key points in our stickers, developed as part of the antibiotic care bundle, but it’s our system. [Do you use the PDSA cycle?] No, we have ongoing audit cycles, which, I guess, serve the same function but they’re part of the health board’s audit regimen and not informed by the 1000 Lives+ programme.

Pharmacist, Antibiotics Medicines Management, case site B2 (001); transcription 8:24

[When you think of 1000 Lives+, what does it mean to you?] That’s a good question. What does it mean to me? I’d say it’s pretty much invisible. I guess it’s one of a number of elements that we take into account on a day-to-day basis. It’s tricky because you’re undertaking CPD [continuous professional development] all the time. It’s probably not recorded as CPD but every article you read in the PJ [Pharmaceutical Journal] is all CPD. For example, I’m going to have a lunchtime teaching session, and there could be two or three things in that that I will take away, and then use in my day-to-day practice. But as a consequence there are things that I will probably drop out by day-to-day practice because they’re become superseded by something else more important. 1000 Lives+ is just one element. There are lots of other things you’re taking in and trying to maintain as current all the time.

Pharmacy manager, case site B2 (016); transcription 8:25

Such disregard was augmented by the notion that, for pharmacists, aspects of 1000 Lives+ have not been ‘translated to pharmacy-speak’ (transcription 8.26). Hence, for this professional group, the resources offered by RHAI were not considered to be a worthwhile innovation in practice (transcription 8:28, below).

If you look the 1000 Lives+, although I think this might have existed with 1000 Lives as well, but I mean, with 1000 Lives+ – I forget what the terminology is but the project theme or something for health-care-associated infection – you have the key intervention areas, if I remember correctly, you’ve got things like standard precautions, hand hygiene and decontamination; isolation precautions, that would be another, and antimicrobial stewardship and so on and so on. But all of these are in the strategies we’ve had in Wales for years! So they, they’re not new and they’re not separate are they?

Pharmacist, Antibiotics Medicines Management, case site D2 (020); transcription 8:28

Second-order emergents and situational logic

In case sites A–D, the interplay of structural, cultural and agential emergent properties impacted on the three groups of actors directly involved in the operationalisation of RHAI. First, in structural terms, RHAI was integrated into the social system-level but was overshadowed by existing systems. Second, in cultural terms, though internal and necessary complementarities could be seen between the RHAI and the array of professional logics in play, this was not considered to add much to already existing principles and procedures and was largely disregarded. RHAI, therefore, operated under a situational logic of protection that was primarily directed towards the pre-existing structural and cultural system-level, and thus to sociocultural interaction aligned with long-established practices.

Sociocultural interaction: agency and strategic negotiation

As discussed in Chapter 6, a situational logic of protection is typically associated with a defensive negotiating stance. However, for RHAI, prior systems of HCAI surveillance and developed IPAC practices overshadowed the intervention. The progressive institutionalisation of the 1000 Lives+ national programme and RHAI, therefore, unfolded in a terrain marred by a degree of disdain. We highlight this complex interplay in both a discrete case site and across multiple case sites, again drawing out different degrees of bureaucratisation and normalisation to help enrich our understanding of the institutional work complementary to the interplay of the focal intervention, context and mechanism.

Power-induced compliance and political sanction

To examine the issues of power-induced compliance and political sanction, we considered individual actors’ strategic negotiating stances across different case sites and professional roles.

It was clear that the IPAC team, in the broader sense, were connected to the managerial core (transcription 8:30). However, they were also intermittently connected to ward-based functional health-care teams, though IPAC nurses and pharmacists undertook regular ward visits as part of their practice. This created a context in which such roles, while offering advice and expertise, also functioned as part of the ward-based governance of IPAC.

However, this oversight role was compromised. Poor practice was adapted in the presence of IPAC nurses, changing so that it demonstrated, while observed, close adherence to the hand washing guidelines of RHAI (transcriptions 8:31 and 8:32, below). This finding was corroborated by our observation of practice at each case site.

There’s some wards you go to and, you know, 1000 Lives+ is just an aside, an extra element of work. For example, you ask them about commode cleaning and they say: ‘well, we don’t have to clean it after every patient’, and then we say: ‘but you’ve got to, that is part of the task, it’s part of the commode bundle’, and they roll their eyes and argue: ‘well, we haven’t got the time’.

I think, wow, if you haven’t got time to just clean a commode, what else have you not got time for? It’s almost as if everything on some wards is seen as on top of what they’re trying to do, you know, because they’re so run ragged, which is understandable, but that’s when it’s harder, then, to implement something new: when they can’t even be doing the things that they should be, you know?

[Can you mandate adherence to these guidelines?] Yes, we tell them, and we audit them, but because we are all known to staff, the minute we walk onto a ward their practice changes. [So they adopt the expected behaviour when you are present?] Yes.

Nurse, IPAC, case site D2 (019); transcription 8:31

About 90% of the staff in ITU [intensive therapy unit] are familiar with me. So, they all know me, and they all know what my job is. When I walk in twice a year, even if they don’t know my name, they know who I am – that sounds really self-important, and that not the issue, but they know me and it’s a problem – and people often will come up, and they’ll stand and chat to me and wash their hands, and I know perfectly well that they’ve done absolutely nothing – they haven’t been near a patient – it’s just that conscious effort to demonstrate hand washing. They’ll walk into ITU, they’ll have a squirt of alcohol gel, and they’ll be watching me, looking at me, to check I’m watching them. So now I sent up [namea] and [nameb], both IPAC as most of the staff don’t know them. So, they went up, on the pretext of looking through patients’ notes, and the hand hygiene practice was not acceptable. But, as soon as they realised that they were being audited, their practice changed immediately. They were like washing their hands, alcohol gel, everything changed.

Nurse, IPAC, case site B1 (137); transcription 8:32

The IPAC staff demonstrated the professional role-positional power to challenge poor practice within extant bureaucratic governance processes. However, confronted by normalised malpractice and decoupling from pre-existing and repacked RHAI standards, their institutional work was predominantly corrective.

Similar corrective institutional work was also demonstrated in the ward-based actions of pharmacists with expertise in antibiotic medicines management (transcriptions 8:34 and 8:35, below).

We don’t get all doctors following the antibiotic prescribing guidelines. Some do, some don’t. So it’s a core part of the role for pharmacists to challenge and change that when they do their ward rounds.

Pharmacy manager, case site D1 (021); transcription 8:34

[What happens if a doctor prescribes off guidelines within the health board?] We challenge them. I had one, a few days ago, who I challenged because he had prescribed two drugs, and only one was needed for the patient’s indication; but all he said was: ‘so what’s the problem, it’s not illegal is it?’ But it’s a waste of money, medicine, and more of a risk and inconvenience for the patient. I think that a lot of my role is really about education and changing the culture in the health board. [But is that refusal to follow the guidelines reported to anyone?] Yes, all the audits go to the medical director. But it’s anonymised data: ward level, not prescriber level. One of my colleagues in [name, health board] has done this per consultant team, and they’ve had good results in changing prescribing because the data is ranked. Everyone knows who’s playing ball, and more importantly, who’s not, so to speak.

Pharmacist, Antibiotics Medicines Management, case site B2 (001); transcription 8:35

In this example, though such staff demonstrated the professional role-positional power to challenge poor practice and enacted corrective institutional work, the lack of transparency and feedback at this site, compared with the respondent’s example of another site, where ’everyone knows who’s playing ball, and more importantly, who’s not, so to speak’, only served to erode the goals of RHAI.

Reciprocal exchange and harmonisation of desires

Gaining widespread support and agreement for a harmonised approach to IPAC, and thus RHAI, proved difficult due, in part, to individual prescribing preferences and ensuing practices. Indeed, this issue was a consistent theme at each case site and across professional groups (transcriptions 8:36 and 8:37, below).

Getting agreement between the all of the consultant microbiologists in the health board is quite demanding but that pales into insignificance when we have to start telling other medical consultants or surgeons what they are supposed to prescribed for a given indication. You know this as much as me! They’re all got their preferred drugs, ones that they have used for years, new ones that offer more, and cost more, it’s that debate that difficult, and it’s one we are having to address due to the formation of the health board.

Consultant microbiologist, case site B1 (036); transcription 8:36

I don’t know if they’ll all agree to a health board-wide antibiotic policy. I mean, we’ll get agreement on the overarching health-care-associated issues – say C. diff management because that’s changing, and it’s our area per se: they don’t want to claim that for themselves – but it’s harder to negotiate with respiratory physicians, orthopaedics, all the rest, as they’ve got their preferred drugs. So changing their prescribing practice is difficult. Our policy is monitored by pharmacists, and IPAC nurses, as they work at ward level, so they are at the sharp end.

Consultant microbiologist, case site C1 (034); transcription 8:37

The comment from a respondent that ‘To change something – whether you’re talking about the 1000 Lives+ work, adherence to current policy guidelines, or the development of new guidelines across the health board, you’ve got to know the people involved in the system’ (transcription 8:38) highlights the critical role of contextual relational structure and social interaction in the brokerage of such contested change. Leadership and the use of co-opted medical power were also seen as central to the negotiating stance employed (transcriptions 8:39 and 8:40, below).

On the wards, well, you’ve got issues, other things, you know, if you’ve got high sickness rates on a ward as well, motivation is often low, so when you’re trying to introduce 1000 Lives+ guided change that’s going to impact more on their workload, often that’s seen as a negative. The key issues then is, how do you really sell that to them because it’s no good us saying: ‘this is all the new paperwork, go on, use this’, the wards have got to see the benefits of that, and own it, and want it, for it to work. I think that’s where good leadership comes in because it’s sort of, you know, if they sell it, if the ward manager sells it as this is a positive thing: ‘if we do this we can reduce our rates’, the staff will be on board.

Lead nurse, IPAC, case site A1 (037); transcription 8:39

We’re having problems with the PVC insertion bundles because we went on the sticker route for the insertion bundles, whereby you put the sticker on the prescription chart, on the PRN [as required medication] side of the prescription chart. Well, every time they went to change a cannula they would just need to sign the prescription chart to say that they’d changed it, and the sticker will have things like hand hygiene, personal protective equipment, and the right dressing on it, you know. But doctors insert venflons and doctors don’t like to document that they’ve inserted something! So when we spoke with the associate medical director at the time, he suggested that we approached clinical champions to try and embed that a little bit further. So with the audit work and the regular feedback, and identifying clinical champions, we’ll begin to see an improvement in compliance, you know, if we don’t, we’ll feed it back to them.

Nurse, IPAC, case site B1 (131); transcription 8:40

Although these IPAC nursing staff demonstrated the professional role-positional power to challenge poor practice, their corrective institutional work, buttressed by the power of others, was directed towards the maintenance of best practice and its evolution through RHAI.

Structural elaboration or reproduction in the Welsh health-care field

In examining the progressive institutionalisation of the 1000 Lives+ national programme’s RHAI we sought to gauge key actors’ perceptions of the structural elaboration or reproduction that had manifested under a situational logic of protection. For consultant microbiologists, attributing improved outcomes in HCAIs to 1000 Lives+ or RHAIs was considered to be very challenging, owing to the interplay and collective impact of multiple IPAC policies on WHAIP’s robust epidemiological modelling (transcription 8:41, below).

If you’re looking at say, catheter care policy, now, looking for it to reduce catheter-associated UTIs [urinary tract infections] then that’s going to be a small subset. So, it’s very, very difficult to be able to draw and demonstrate a reduction. It’s technically possible, if you have a big enough study population. However, practices in hospital are not static, things change, for the better, for the worse, for a whole host of reasons, and controlling any one aspect through 1000 Lives+ policy, or something of that nature, that may have one impact but there may be contrary aspects that the main path is working on. So, it can be, I think, very challenging, and very difficult to really show a reduction and improvement in outcomes.

Consultant microbiologist, case site A1 (035); transcription 8:41

Structural change was apportioned to the ward-based functional health-care team. In enacting RHAI and other IPAC guidelines, such staff not only delivered change (transcription 8:42, below), but were continually motivated to do so through fear of exposure of failings (transcriptions 8:43 and 8:44).

Our C. difficile rates have actually gone down, a reduction again on last year. So it’s good. But, you know, that’s where our support and advice has come in. But at the end of the day, in infection control, we’re not there on the coalface, if you like, it’s the staff who put that into practice, into place, you know, they carry on with what we advise. So, you know, a lot of the hard work is down to them.

Nurse, IPAC, case site D2 (019); transcription 8:42

Cultural change, by contrast, was perceived to be far more marked, with a professional logic of zero tolerance of HCAIs emerging across NHS Wales, although it remained far removed from the reality of day-to-day health-care practice (transcription 8:45, below).

I think the culture is changing, I mean, I’ve seen it in the short time I’ve been in infection control, the ownership at ward level for infection control has shifted. Whereas, you know, if there was a problem on the ward, often the wards wouldn’t call us, so we would find out by our surveillance!

But now wards are contacting us to say: ‘I think we’ve got a problem’, so there’s the acceptance of their role in infection prevention and control. Before, for Clostridium difficile, it was accepted that it’s just a consequence of being in hospital – the attitude was: ‘what do you expect, you’re going to have antibiotics, you’re elderly, you’re bound to get it’ – but that is changing now. Now people are saying: ‘no, they shouldn’t be getting a health-care-associated infection, it’s just not good enough’. There should be zero tolerance on infection, health-care-associated infection. [But they still happen, don’t they? And patients still die as a consequence, don’t they?] Yes. [Long pause] But I think at ward level staff now are not accepting that patients should acquire an infection as a result of being in hospital.

Nurse, IPAC, case site B1 (131); transcription 8:45

In addition, though tangential to RHAI, the normalisation of the 1000 Lives+ MI-PDSA approach was evident (transcriptions 8:46 and 8:47). However, the crux of such cultural change lay in the education of staff (transcription 8:48, below, and transcriptions 8:49 and 8:50).

Education is key, too, not just education for the sake of antibiotic education but to change the culture. But, again, we face a huge problem here as the attitude is: ‘well, what’s the problem; why do we need to change how we do things; the evidence is weak’, it’s always the same.

I don’t want to sound cynical, I don’t. I love my job. But getting people to change is difficult, especially doctors, though they do know that I know what I’m on about. But we go through the same issues with each junior doctor rotation – I feel that I have to re-prove myself to them because they prescribe, wrongly – I know what they should be prescribing better than they do. So, a large part of what I do is education, and not just about drugs.

[Do you think that the junior doctors respect the work you do?] If they’re arrogant, and think they know it all, probably not; but they’re the most dangerous. Once you’re stopped them from killing a patient, once or twice; once they’ve realised how fallible they’re, and how, within the NHS, you’re lucky if you got a good team around you, who all know their own profession and offer different expertise, they start to listen. They’re not all like it, thankfully. Some are really good, and with more joint training early on in health-care professional careers, I think the issue of professional respect is getting better. But the best doctors are those that listen, and, more importantly, they ask for information and advice, they’re keen to learn, and you know they’re going to be good because they work constructively within the team. But with some with doctors, we often just get point blank refusal to co-operate.

[What are the consequences of this? How does the audit cycle, and associated governance processes intervene to feedback in such circumstances?] Well, the pharmacy audit will be sent to the medical director but, with the lack of prescriber identification, and data aggregation, it gets blunted.

Pharmacist, Antibiotics Medicines Management, case site C1 (013); transcription 8:48

1000 Lives+ institutionalisation: RHAI – local implementation of the focal intervention and contribution to the I–CMAO configuration spanning the Welsh health-care field

Our efforts to understand the local implementation of RHAI, and define its contribution to the 1000 Lives+ programmes’ I-CMAO configuration spanning the Welsh health-care field, were limited, as there was a profound sense of it being overshadowed by the complex array of established alternative frameworks and the ongoing surveillance of their effectiveness via the WHAIP. Indeed, RHAI was found to be, in some respects, a leftover theme from the predecessor 1000 Lives campaign. Furthermore, for some staff, the legacy effect of the Safer Patients Initiative was more pertinent. Consequently, though the institutional change inherent to formalisation shaped the situated context of action for all, the impetus of RHAI, nonetheless, dissipated.

Turning now to the findings of our realist analysis, we first consider, in Figure 22, the overall scheme of the intervention across the different structural contexts, focusing, for simplicity, on only one of the two processes researched in this part of the study, namely the appropriate use of antimicrobial drugs to ensure the effective prevention and treatment of infection.

FIGURE 22. Reducing health-care-associated infection: heterarchical metamechanism operating across contextual strata – management of antibiotic drugs.

FIGURE 22

Reducing health-care-associated infection: heterarchical metamechanism operating across contextual strata – management of antibiotic drugs.

Figure 22: key point summary

In Figure 22 we depict the implementation of local antibiotic guidelines in association with the RHAI focal intervention.

At point 1 we draw attention to the formalisation of this process via professional guidelines and Welsh Government policy, thereby mandating engagement by all health boards, health-care staff with prescribing privileges and pharmacists with expertise in antibiotics medicines management.

In point 2 we highlight that, although such practices are legitimate and formalised, under the 1000 Lives+ national programme they represent established practices which do not represent or drive innovation.

Point 3 highlights illustrates that such mandated engagement may be opposed across the micro-work system.

In Tables 2830 we show, respectively, I-CMAO configurations for the implementation of RHAI, illustrating the infrastructural system of the Welsh Government, the institutional setting of NHS Wales and its constituent health boards, and interpersonal relationships within the institutional settings.

TABLE 28

TABLE 28

Reducing health-care-associated infection I-CMAO configuration: infrastructural system – Welsh Government

TABLE 30

TABLE 30

Reducing health-care-associated infection I-CMAO configuration: institutional setting – interpersonal relations

TABLE 29

TABLE 29

Reducing health-care-associated infection I-CMAO configuration: institutional setting – NHS Wales and constituent health boards

Tables 31 and 32 report data relating to the incidence of two types of hospital-acquired infection made publicly available as part of the new emphasis on transparency in relation to patient safety.

TABLE 31. Reducing health-care-associated infection: local implementation – WHAIP.

TABLE 31

Reducing health-care-associated infection: local implementation – WHAIP. Data are rates of MRSA bloodstream infections per 100,000 bed-days

TABLE 32. Reducing health-care-associated infection: local implementation – WHAIP.

TABLE 32

Reducing health-care-associated infection: local implementation – WHAIP. Data are rates of S. aureus bloodstream infections per 100,000 bed-days

Finally, in Table 33, we present our realist analysis linking the empirical data to I-CMAO.

TABLE 33

TABLE 33

Reducing health-care-associated infection: realist analysis – signposting how the empirical data connect to I-CMAO

In this context, deinstitutionalisation did not occur. After all, no appreciable change to practice was required. As illustrated in Tables 3133, RHAI placed emphasis on well-established health-care practices, each supported by a wealth of tacit knowledge and a burgeoning evidence base, which were institutionalised in NHS Wales. Hence the information offered by the discrete components of this intervention was neither new nor challenging to extant practice. Instead, these components were merely the continuation of standard precautions for hand hygiene, together with the ongoing debate on appropriate antimicrobial prescribing and the merger of guidelines that was required following the reconfiguration of NHS Wales.

In addition, the transcriptions set out in in Tables 2830 depict high levels of decoupling. This finding is supported by the wider literature. For example, it is known that hand hygiene benefits from entrenched ideas about its meaning and broader social utility.352 This most basic of practices, therefore, constitutes a cognitive and behavioural ensemble that demands little by way of organised competencies.595,626 However, in order to be effective, hand hygiene must be enacted as a conscious activity.630 But its broader social utility positions this practice as routine and somewhat mindless696 and habitual,697 which limits the individual’s reflexive monitoring and appraisal of the practice.

Moreover, as RHAI did not demand change, theorisation was not triggered, so that established factors inhibiting actors’ meaningful participation629,645,658 persisted. Compounded by environmental contamination,698 these factors encouraged the spread of nosocomial infection.

As illustrated in Table 33, and supported by the explanatory schematic Figure 22, our realist analysis adds insight. Centred on pharmacists with expertise in antibiotic medicines management, sociocultural interaction through the wide range of activities depicted in this study, though undertaken in logical alignment to the RHAI, were marred by the lack of appreciable change demanded. Indeed, only the new interventions, focused on the appropriate and timely use of invasive devices – specifically guidance aimed to reduce PVC and CAUTI – prompted cognitive participation and collective action to deliver change. Accordingly, little structural elaboration was displayed across each case site, compounded by the view expressed by some pharmacists that RHAI did not offer any substantive enhancement of their practice.

Summary

In Chapter 8, we furthered our understanding of the local implementation of the focal intervention RHAI and defined its contribution to the 1000 Lives+ programmes’ I-CMAO configuration spanning the Welsh health-care field.

Copyright © Queen’s Printer and Controller of HMSO 2015. This work was produced by Herepath et al. under the terms of a commissioning contract issued by the Secretary of State for Health. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journals provided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should be addressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK.

Included under terms of UK Non-commercial Government License.

Bookshelf ID: NBK316560

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