2NPP


Conserved Protein Domain Family
B56

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pfam01603: B56 (this model, PSSM-Id:396263 is obsolete and has been replaced by 460264)
Protein phosphatase 2A regulatory B subunit (B56 family)
Protein phosphatase 2A (PP2A) is a major intracellular protein phosphatase that regulates multiple aspects of cell growth and metabolism. The ability of this widely distributed heterotrimeric enzyme to act on a diverse array of substrates is largely controlled by the nature of its regulatory B subunit. There are multiple families of B subunits (See also pfam01240), this family is called the B56 family.
Statistics
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PSSM-Id: 396263
Aligned: 108 rows
Threshold Bit Score: 241.749
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2NPP_B        34 PPADQEKLFIQK--------LRQCCVLFDFvSDPLSDLk-wKEVKRAALSEMVEYITHnr--nVITEPIYPEVVHMFAVN 102
EAX96923      80 NNPEFKNIFLHK--------LNLGCQVF-----SDMDPn-qRLAKRIVLHQVAECIITlgigpFIDSEMTSKVYEMIYVN 145 Trichomonas vag...
EAX87284      90 NDSQFKSILLKK--------LDLCKQLCDF-ENPCNDRq-aKDIKKHTLIEINNSFTTlglnsISDDEIKDTILDVIKIN 159 Trichomonas vag...
EAX88513      75 GDPSFKNIMMKK--------IELCKQMCDF-DNPNNDKd-aKIIKANALQEISNRFSNlginsYIDEDIRVNLVQMIKTN 144 Trichomonas vag...
XP_001308485  33 iSKNTKNIFINSnditfytlCKYCSTQIDI-NDAMLQEk-iNN-KTIYLKQILEYLQNtd-csKISDKLLQIFFFMVEKN 108 Trichomonas vag...
XP_001321072  71 KENEVKDLIVSK--------CKIAKQNVDL---SRQDLavyATGKEGYLFDILETLQDknfnlPQDPDVYSAIISLVAFH 139 Trichomonas vag...
EAY14569      78 PPKDCKLYFKIK--------CNECAKICDF-SNPNKDTq-aKANKISLLRHIISSYQIphiarSLSQDLIQEFYNMISSN 147 Trichomonas vag...
EAY10107      66 PQNEYAKLFLHK--------CKECSKLCDF-SDANIDGk-aKVTKSILLKHLTQCFSMvgfmkILTAEMMTEFYKMVSTN 135 Trichomonas vag...
EAY23667      64 DPKEYNTVFAQK--------VKECQKICDF-SIGVKDVv-aKKTKSDLLKDIMTAFDSpeimhLLTPSSYEKYFKMVTKN 133 Trichomonas vag...
XP_001307541  61 PPKDQQKLLLEK--------CHECCVICDF-SSANADAk-aKQTKATLLKHIAAAFTIphlvrSMQTDTINEFLNMLSVN 130 Trichomonas vag...
2NPP_B       103 MFRT---LPps--sNPT-GAEFd--pEEDEP---TLEAAWPHLQLVYEFFLRFLESP-DFQPNIAKKYIDQKFVLQLLEL 170
EAX96923     146 IKRP---VPkfelnQFLnSDSGc-----------FSVPEWEHLEFVYTIFQIFYKTFpKLEF------WTTQFFESLIPL 205 Trichomonas vag...
EAX87284     160 LLRP---LNkldelTLFnPDVGa-----------FKEFDFEHMEYIYRMLNTLYRDMpKYKG------FNIDLLVQLLPV 219 Trichomonas vag...
EAX88513     145 LIRP---LSklddiSLFfSDINs-----------FHLEDFQHTQHIYKILTFFFRDFpKYEI------FDIKFMKELIPV 204 Trichomonas vag...
XP_001308485 109 LFHD---NYfps------------nlSPDYPseeKYDIFWVHNKLIYAQLMIITESF--------PEYLNFSLIYRIISN 165 Trichomonas vag...
XP_001321072 140 IFRTvtiLP-----DLWnSVHDdyyfEMDT----FSDPQWPHRVIIYDTAIALFKRS-DFNIEKCKLLATDLFKL-VVYL 208 Trichomonas vag...
EAY14569     148 LFRE---FPpvkiiDLHdGSIPd-----------VQDASWTHLSIIYEALNGMIDISnAPDF-------PPNFIANIARN 206 Trichomonas vag...
EAY10107     136 LFRA---LPrypeaVPVdAKVS------------FYDNSWPHLSLVYQVLNASLSSH-------FAANITPTFIYKIISN 193 Trichomonas vag...
EAY23667     134 ICRP---MPqikivSPLdVDDQ------------VQDTAWPHLFLVYKTLNTLMESN------NVPTCNNKNLVQALVSN 192 Trichomonas vag...
XP_001307541 131 LFRP---FPtipsvSPIdAHDS------------LSDASWPHLSLVYDSLLASLNCP------LIQNSITTSFLYKLIGN 189 Trichomonas vag...
2NPP_B       171 FDSEDPRERDFLKTTLHRIYGKFLGLRAYIRKQINN------------IFYRFIY-----ETEHHNG------IAELLEI 227
EAX96923     206 ISSRDTLERDRLAIILSTYY----INNPILLHGFAL------------KLAKIIE--------NHFItpdpcaVYTALTI 261 Trichomonas vag...
EAX87284     220 LSSKDKRERELIIQFYVNVL----TAKPKLFPEIFP------------KLIRILI--------SDYFdpdpcgIYSALSI 275 Trichomonas vag...
EAX88513     205 LSSRDIRERDMIIAFMVSLI----QAKNNLFNQILP------------SLIKIID--------HHFVdidpcgVYSALGI 260 Trichomonas vag...
XP_001308485 166 TLSIDSRERQTALKFIRNIYDKNLDVRSDIKSAIISqlslinaskeflAFIRYIIedyfnDKRNY--------VSKIKKL 237 Trichomonas vag...
XP_001321072 209 MRTPNKEEQRKLTELYVCMIPKLGEFRSFAINVTNS------------ALARIAF-----SDENFIA------TKPLLQV 265 Trichomonas vag...
EAY14569     207 FYSFDSRERQQVCNTLIAISNKFPQCRVHIRKRIVD------------ILSSNYC------------------ASAILDW 256 Trichomonas vag...
EAY10107     194 GLSIDPSERVAVRDFLHSYYSRFMGQRVMIRTDIFG------------LFSMGQA------------------SLELLDF 243 Trichomonas vag...
EAY23667     193 CCGPDDRERFACKDILRKMYSKCPNLQQLILRAVVS------------QFQTKQC------------------SADLLEF 242 Trichomonas vag...
XP_001307541 190 CVSPDDREKAVVRDILHALYTKFIHLREIVRSNIAY------------QFSNNIC------------------SSELMEF 239 Trichomonas vag...
2NPP_B       228 LGSIINGFALPLKEEHKIFLLKVLLPLHKVKSLSVYHPQLAYCVVQFLEKDSTLTEPVVMALLKYWPKTHSPKEVMFLNE 307
EAX96923     262 FSNIIAS-SIENRNMAFNLCNNLCIQLIQNQYLSIFISPFSNLLKMILPLSETLTLILLNGIVKYWPVSDPAKQVPMIKL 340 Trichomonas vag...
EAX87284     276 IYSCQQS-NNNLKDIIKPYYHSHFLPLIRHEHFGVFYFPLLQLLKMFFTNNYSNTNEFVRLIINIWPISKPAKEEMMLDF 354 Trichomonas vag...
EAX88513     261 MKGVIKE-IPSFWRVIQPMFQTHLLNLLRYDCLRVYADPLSEIFSLFYNNNSIYSKNTIELLVSIWPVSNPSKEEIMINI 339 Trichomonas vag...
XP_001308485 238 TKNLKNDFIVKNEEIGQDFFIDLLLPLHNHDNYELFSGELLEIEFIFFKNDTKLVDYSIKYILMHWPITNIRKQDAFLRE 317 Trichomonas vag...
XP_001321072 266 MRSHAEGFHTPLKKVHQIFYLDVILPLHKHKHSHYFWQDLVSTVTAFLDKEPNLVFPTYEFIVNVWPRMCTTKQLDFIDE 345 Trichomonas vag...
EAY14569     257 MLSYANGLSIPLKQDSIDMFMKVLLPLHTLPNFCDYSKQIQVLMYTFIVKQPELFAYVANFIIVHWPIANVYKQVAFIDE 336 Trichomonas vag...
EAY10107     244 FSSIVQGFNPPLKADHVKFFNQALLPLYTYSELNRYSKALTSCVCKFCEKNFNLISVAFDYLYKHWPLQDSKKQKIYIDS 323 Trichomonas vag...
EAY23667     243 FGKVVAGYQAPLTAEQISTYKNAVLFLHSSPNFLKFCLNLLQVINQHIKLDPSLYEPTIEYIISHWPSLSIRKQILMLSE 322 Trichomonas vag...
XP_001307541 240 FLSIVSGFNAPLKQDHVDFYYKYVLPLHCTQKYSSIQRPFVQCTVKFIQKSILLFTPTVMYIAKHWPCSDRRKQIDFLNE 319 Trichomonas vag...
2NPP_B       308 LEEILDVIEPSEFVKIMEPLFRQLAKCVSSPHFQVAERALYYWNNEYIMSLISDNAAKILPIMFPSLYRNSKTHWNKTIH 387
EAX96923     341 IIAALFSNHSMNDGVILKKVFLLLGELCDTEFFKVADQACKCLQEEVILGLLSNNCREIVPYIMTHVRSSLK-HWYAPLR 419 Trichomonas vag...
EAX87284     355 LVQSLEFARNIDYRLL-GRAFKIIGSLCDSPSFKVAEKANKIIISPVLMELISQASTKILPFLLVHIENARN-HWSNTVR 432 Trichomonas vag...
EAX88513     340 LSSALDF-PEAINNALLCHIVDIVAISIDSPSHKIAEAANRLFVQPSFTELVSKNRKTFTVKLLPHVENART-HWNEKIR 417 Trichomonas vag...
XP_001308485 318 IFDLLLNFQNVMSNQVKIDSFVMVCKCIESLNANIAKTAIKIIINPEFKGTLEKLSVICLPLLISSLRINVAKHWDPEIR 397 Trichomonas vag...
XP_001321072 346 IGILASFVPDEETSKVTKILLPQYCRTIVGVNAWSSKRALALFDINDFVWLMTEVPGDVYPSLIPSLYECAKIHWDGDAR 425 Trichomonas vag...
EAY14569     337 LDIIFSKYSQASQTQHFQMFFKFLCNLLSDQSYQVTDKVMTVLSNKGYYPIIKDHSNGIIFNLVTALLDTSANHWSTDVR 416 Trichomonas vag...
EAY10107     324 VKIILFSFDKFSDTS-LRRAFAILAEGVRSDNVDVAEIALDTLLAENLVLVYKQNPRLIFTTIFEKLYKSAKSHWDEDIK 402 Trichomonas vag...
EAY23667     323 VEGLFLGFPKLLNERSSKLVFTLLSELITQPNIDLSETSCNVIIGPALEEALLAFTPLAHKILDEQLLSVARNHWNDFVR 402 Trichomonas vag...
XP_001307541 320 LTTLLSTFELNVSPKVASTIFKIVGDCVESENTDVSEASVDFLMNPELASVIRTHSTIVFPIVIEPIYRAAKHHWDECTK 399 Trichomonas vag...
2NPP_B       388 GLIYNALKLFMEMNQKLFDD-CTQQFKAEKLKEKLKMKEREE---AWVKIENLA 437
EAX96923     420 ETAQVTLRVLCQIC----------------QERRSDDIGLNVrtsNWVSIARTA 457 Trichomonas vaginalis G3
EAX87284     433 IAAEDSMTSISRLMGRSAN-----------RKKQEDLNNSKEklkSWASIARAA 475 Trichomonas vaginalis G3
EAX88513     418 SLGNESNLAILRMNPNIKSK----------KIQDATTDTNKTklkGWASIARAA 461 Trichomonas vaginalis G3
XP_001308485 398 KISQKSINYLTNLDP------VAS------KRNPYDKKKDSSykdDWNTIYKIA 439 Trichomonas vaginalis G3
XP_001321072 426 NLALACLNVLRDNNRKIFNVvGKA----MKMLENQRIVTDIKramKWKELIdnf 475 Trichomonas vaginalis G3
EAY14569     417 KKSCTSLALLESYDANSYKKsVEA----QKIMNTRRKAQLGLcksTWQRVIDEA 466 Trichomonas vaginalis G3
EAY10107     403 TDSIAALQILSEIDPNIFGE-LNNAHKDKKNTKKAPVKEASAlktNWMQVFNLA 455 Trichomonas vaginalis G3
EAY23667     403 DDSKLALQMMSDIDNDLLEEtLNN----SKDTKKRKKANNLIwktNWAKVFETA 452 Trichomonas vaginalis G3
XP_001307541 400 TNAYVVLQVLSEIDNQTFNKaNDA----HKLMKAQKSASFAVfknNWTRIFENA 449 Trichomonas vaginalis G3
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