GPL18573[RGSE] - GEO DataSets

Search results

Items: 1 to 20 of 12333

<< First< Prev

Page of 617

Next >Last >>

Select item 2002759351.

HIV-induced RSAD2/Viperin supports sustained infection of monocyte-derived macrophages

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL18573 GPL15433
21 Samples

Download data

Series

Accession:: GSE275935

ID:: 200275935

Select item 2002756852.

GATA6 regulates WNT and BMP programs to pattern precardiac mesoderm during the earliest stages of human cardiogenesis (CUT&RUN)

(Submitter supplied) Haploinsufficiency for GATA6 is associated with congenital heart disease (CHD) with variable comorbidity of pancreatic or diaphragm defects, although the etiology of disease is not well understood. Here, we used cardiac directed differentiation from human embryonic stem cells (hESCs) as a platform to study GATA6 function during early cardiogenesis. GATA6 loss-of-function hESCs had a profound impairment in cardiac progenitor cell (CPC) specification and cardiomyocyte (CM) generation due to early defects during the mesendoderm and lateral mesoderm patterning stages. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL18573
5 Samples

Download data: XLS

Series

Accession:: GSE275685

ID:: 200275685

Select item 2002728273.

Activation of polo-like kinase 1 expression in spinal motor neurons as vulnerability factor of spinal motor neurons in FUS- and other fALS

(Submitter supplied) FUS ALS seems to preferentially affect sMNs, and cognitive dysfunction in FUS ALS is rare. Considering this, we wanted to analyze if cortical neurons behave differently than spinal motor neurons in response to FUS mutations. For this, we used cortical neurons derived from isogenic human induced pluripotent stem cells (hiPSCs) in which either WT or NLS mutant FUS P525L was tagged with eGFP using CRISPR/Cas9 and systematically compared them to sMNs of the identical iPSCs. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
12 Samples

Download data: TSV

Series

Accession:: GSE272827

ID:: 200272827

Select item 2002678334.

Tankyrase inhibition promotes endocrine commitment of hPSC-derived pancreatic progenitors

(Submitter supplied) To improve β-like cell differentiation from human pluripotent stem cells (hPSCs), we aimed to substitute a mechanistically elusive compound – nicotinamide (NA), which promotes pancreatic progenitor (PP) commitment, with a pathway-specific compound. By performing a low-throughput chemical screening, we demonstrated that tankyrase inhibitors (TNKSi) can replace NA and efficiently generate PPs. Surprisingly, highly selective TNKSi, such as WIKI4, generate PPs that give rise to islet-like populations with improved β-like cell frequencies and glucose responsiveness compared to NA-derived PPs. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
6 Samples

Download data: XLSX

Series

Accession:: GSE267833

ID:: 200267833

Select item 2002286085.

Recruitment of the m6A/Am demethylase FTO to target RNAs by the telomeric zinc finger protein ZBTB48

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other

Platforms:: GPL18573 GPL16791 GPL24676
28 Samples

Download data: TXT

Series

Accession:: GSE228608

ID:: 200228608

Select item 2002286076.

Recruitment of the m6A/Am demethylase FTO to target RNAs by the telomeric zinc finger protein ZBTB48 [iCLIP-seq]

(Submitter supplied) Fat mass and obesity-associated protein (FTO) can remove both the N6-methyladenosine (m6A) and N6, 2′-O-dimethyladenosine (m6Am) methylation marks that function in multiple aspects of posttranscriptional regulation. Here, we demonstrate that Zbtb48, a C2H2-zinc finger protein that functions in telomere maintenance, associates with FTO and binds both mRNA and the telomere-associated regulatory RNA TERRA to regulate the functional interactions of FTO with target transcripts. more...

Organism:: Homo sapiens

Type:: Other

Platforms:: GPL18573 GPL16791 GPL24676
20 Samples

Download data: BED, PDF

Series

Accession:: GSE228607

ID:: 200228607

Select item 2002286057.

Recruitment of the m6A/Am demethylase FTO to target RNAs by the telomeric zinc finger protein ZBTB48 [ChIP-seq]

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL18573
4 Samples

Download data: BED, NARROWPEAK

Series

Accession:: GSE228605

ID:: 200228605

Select item 2002281848.

Trained immunity is facilitated by T cell-induced CD40-TRAF6 signaling

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL18573
27 Samples

Download data: BIGWIG

Series

Accession:: GSE228184

ID:: 200228184

PubMed Similar studies

Select item 2002281839.

Trained immunity is facilitated by T cell-induced CD40-TRAF6 signaling [RNA-seq]

(Submitter supplied) Trained immunity refers to epigenetic and metabolic changes in innate immune cells following exposure to inflammatory signals, leading to a heightened response to secondary stimuli. Although this innate immune memory contributes to host defense against infections, it can also have maladaptive consequences in a broad range of immune-driven conditions. During the past decade, we have gained an increasingly better understanding of the molecular regulation of trained immunity, but the role of adaptive immune cells in modulation of trained immunity remains largely unknown. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
9 Samples

Download data: TXT

Series

Accession:: GSE228183

ID:: 200228183

Select item 20022818210.

Trained immunity is facilitated by T cell-induced CD40-TRAF6 signaling [ChIP-seq]

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL18573
18 Samples

Download data: BIGWIG

Series

Accession:: GSE228182

ID:: 200228182

Select item 20027183711.

ZNF143 is a transcriptional regulator of nuclear-encoded mitochondrial genes that acts independently of looping and CTCF

(Submitter supplied) Gene expression is orchestrated by transcription factors, which function within the context of a three-dimensional genome. Zinc finger protein 143 (ZNF143/ZFP143) is a transcription factor that has been implicated in both gene activation and chromatin looping. To study the direct consequences of ZNF143/ZFP143 loss, we generated a ZNF143/ZFP143 degron line. Our results show that ZNF143/ZFP143 depletion has no effect on chromatin looping. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL18573
14 Samples

Download data: BED, BW

Series

Accession:: GSE271837

ID:: 200271837

Select item 20021355512.

Molecular and pathological characterisation of diffuse large B-cell lymphomas in children with Nijmegen breakage syndrome

(Submitter supplied) Nijmegen-breakage syndrome (NBS, OMIM #251260) is an autosomal recessive chromosomal instability syndrome characterized by a very distinct phenotype (microcephaly, growth retardation, immunodeficiency) associated with increased predisposition to develop malignancies, particularly of lymphoid origin (by the age of 20 years, over 40% of NBS patients develop cancer). Immunological lineage of lymphomas in NBS significantly differs from Non-Hodgkin Lymphomas (NHL) entities observed in general pediatric population as well as in primary immunodeficiencies. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
41 Samples

Download data: CSV, TAB

Series

Accession:: GSE213555

ID:: 200213555

Analyze with GEO2R

Select item 20018260513.

Integrative gene regulatory analysis reveals transcriptional mechanisms required in mature human hepatocytes and during in vitro hepatocyte differentiation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL18573
35 Samples

Download data: BW

Series

Accession:: GSE182605

ID:: 200182605

Select item 20018260414.

Integrative gene regulatory analysis reveals transcriptional mechanisms required in mature human hepatocytes and during in vitro hepatocyte differentiation (scRNA-Seq)

(Submitter supplied) Advances in 3D cell culture systems, including the hepatic organoids, has shown the potential to model the liver development in vitro. However, hepatocyte-like cells obtained by these means are still immature compared to the primary human hepatocytes. Here we applied single-cell RNA-seq and ATAC-seq to identify gene regulatory mechanisms distinct to mature human hepatocytes (in vivo) and organoid derived hepatocyte like cells (in vitro). more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
18 Samples

Download data: CSV, TXT

Series

Accession:: GSE182604

ID:: 200182604

SRA Run Selector

Select item 20018260315.

Integrative gene regulatory analysis reveals transcriptional mechanisms required in mature human hepatocytes and during in vitro hepatocyte differentiation (RNA-Seq)

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
11 Samples

Download data: CSV

Series

Accession:: GSE182603

ID:: 200182603

SRA Run Selector

Select item 20018260216.

Integrative gene regulatory analysis reveals transcriptional mechanisms required in mature human hepatocytes and during in vitro hepatocyte differentiation (ATAC-Seq)

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL18573
6 Samples

Download data: BW

Series

Accession:: GSE182602

ID:: 200182602

SRA Run Selector

Select item 20026960517.

USP50 suppresses alternative RecQ helicase use and deleterious DNA2 activity during replication

(Submitter supplied) Mammalian DNA replication relies on various DNA helicases and nuclease activities to ensure accurate genetic duplication, but how different helicase and nuclease activities are properly directed remains unclear. Here, we identify the ubiquitin-specific protease, USP50, as a chromatin-associated protein required to promote ongoing replication, fork restart, telomere maintenance, cellular survival following hydroxyurea or pyridostatin treatment, and suppression of DNA breaks near GC-rich sequences. more...

Organism:: Homo sapiens

Type:: Other

Platform:: GPL18573
4 Samples

Download data: FASTA, TXT

Series

Accession:: GSE269605

ID:: 200269605

Select item 20026419118.

Secreted factors from M1 macrophages drive prostate cancer stem cell plasticity by upregulating NANOG, SOX2 and CD44 through NFκB signaling

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL24676 GPL18573
30 Samples

Download data

Series

Accession:: GSE264191

ID:: 200264191

PubMed Full text in PMC Similar studies

Select item 20026419019.

Secreted factors from M1 macrophages drive prostate cancer stem cell plasticity by upregulating NANOG, SOX2 and CD44 through NFκB signaling [LNCaP-C42B]

(Submitter supplied) The inflammatory tumor microenvironment (TME) is a key driver of tumor-promoting pro-cesses. Tumor-associated macrophages are one of the main immune cell types in the TME and their increased density is related to poor prognosis in prostate cancer. Here, we investigated the influence of pro-inflammatory (M1) and immunosuppressive (M2) macrophages on pros-tate cancer lineage plasticity. Our findings reveal that M1 macrophage secreted factors up-regulate genes related to stemness while downregulating genes associated with androgen re-sponse in prostate cancer cells. more...