GPL23293[Accession] - GEO DataSets

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Items: 7

Select item 2000977941.

Divergence in DNA specificity among paralogous transcription factors contributes to their differential in vivo binding

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: synthetic construct; Homo sapiens

Type:: Genome binding/occupancy profiling by array

5 related Platforms
28 Samples

Download data: TXT

Series

Accession:: GSE97794

ID:: 200097794

PubMed Full text in PMC Similar studies

Select item 2000976912.

Divergence in DNA specificity among paralogous transcription factors contributes to their differential in vivo binding [RG_Runx1Runx2_v1]

(Submitter supplied) Members of transcription factor (TF) families, i.e. paralogous TFs, are oftentimes reported to have identical DNA-binding motifs, despite the fact that they perform distinct regulatory functions in the cell. Differential genomic targeting by paralogous TFs is generally assumed to be due to interactions with protein cofactors or the chromatin environment. Contrary to previous assumptions, we find that paralogous TFs have different intrinsic preferences for DNA, not captured by current motif models, and these differences partly explain differential genomic binding and functional specificity. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by array

Platform:: GPL23293
4 Samples

Download data: TXT, XLSX

Series

Accession:: GSE97691

ID:: 200097691

PubMed Full text in PMC Similar studies

Select item 1000232933.

Duke/RG_Runx1Runx2_v1 (Agilent 4x180k)

(Submitter supplied) In situ oligosynthesized array with proprietary synthetic sequences that target Runx1/Runx2 putative binding sites in genomic context.