GPL550[RGSE] - GEO DataSets

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Items: 2

Select item 2000016471.

Prediction of toxicant-specific gene expression signatures following chemotherapeutic treatment of breast cell lines

(Submitter supplied) Global gene expression profiling has demonstrated that the predominant cellular response to a range of toxicants is a general stress response. This stereotyped environmental stress response commonly includes repression of protein synthesis and cell cycle regulated genes and induction of DNA damage and oxidative stress responsive genes. Our laboratory has recently characterized the general stress response of breast cell lines derived from basal-like and luminal epithelium following treatment with doxorubicin (DOX) or 5-fluorouracil (5FU) and showed that each cell type has a distinct response. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS1627
Platform:: GPL550
83 Samples

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Accession:: GSE1647

ID:: 200001647

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000007632.

Cell-type specific responses to chemotherapeutics in breast cancer

(Submitter supplied) Recent studies have identified clinical subtypes of breast tumors that arise from different cell types and have different outcomes in response to chemotherapy. Tumors derived from basal epithelium have a poorer prognosis than tumors derived from luminal epithelium. To gain insight into differences underlying this disparity, we treated cell lines derived from basal epithelium (immortalized human mammary epithelial cells) and those derived from luminal epithelium (MCF-7 and ZR-75-1) with two chemotherapeutics commonly used in the treatment of breast cancer. more...