GSE117348[Accession] - GEO DataSets

Warning: The NCBI web site requires JavaScript to function. more...

Format

Summary
Summary (text)
Unique Identifier List

Sort by

Default order
Number of Samples (High to Low)
Number of Samples (Low to High)

Send to:

Choose Destination

File
Clipboard
Collections

Search results

Items: 5

Select item 2001173481.

Divergence in DNA specificity among paralogous transcription factors contributes to their differential in vivo binding [uPBM_Elk1Ets1Gabpa]

(Submitter supplied) Members of transcription factor (TF) families, i.e. paralogous TFs, are oftentimes reported to have identical DNA-binding motifs, despite the fact that they perform distinct regulatory functions in the cell. Differential genomic targeting by paralogous TFs is generally assumed to be due to interactions with protein cofactors or the chromatin environment. Contrary to previous assumptions, we find that paralogous TFs have different intrinsic preferences for DNA, not captured by current motif models, and these differences partly explain differential genomic binding and functional specificity. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by array

Platform:: GPL23935
3 Samples

Download data: TXT

Series

Accession:: GSE117348

ID:: 200117348

PubMed Full text in PMC Similar studies

Select item 1000239352.

Universal PBM 4x44k (Bulyk lab design)

(Submitter supplied) In situ oligosynthesized array with synthetic sequences that cover all possible 10-mers (Berger et al., Nature Biotechnology 2006)