GSM1018110[Accession] - GEO DataSets

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Items: 4

Select item 2000414851.

Expression data of A939572 SCD1 inhibitor treated ccRCC cells

(Submitter supplied) Presently, there is a deficiency of effective therapies designed to target clear cell renal cell carcinoma (ccRCC), with poor prognosis resulting in patients with advanced disease. Additionally, there is a lack of molecular factors which can be remedially targeted resulting in tumor specific inhibition, and therefore current therapeutic approaches often produce adverse side effects in patients. We identified that Stearoyl-CoA desaturase 1 (SCD1) was consistently overexpressed in patient ccRCC samples, and further investigation of SCD1 as a potential molecular target for ccRCC intervention utilizing a SCD1 inhibitor (A939572) resulted in tumor specific growth inhibition and induction of cell death. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS5094
Platform:: GPL570
8 Samples

Download data: CEL

Series

Accession:: GSE41485

ID:: 200041485

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 50942.

Stearoyl-CoA desaturase 1 inhibition effect on clear cell renal cell carcinoma cell lines

Analysis of clear cell renal cell carcinoma (ccRCC) cells treated with A939572, a stearoyl-CoA desaturase 1 (SCD1) inhibitor. SCD1 is overexpressed in ccRCC.Results provide insight into the role of SCD1 in the pathogenesis of ccRCC.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 agent, 4 cell line sets

Platform:: GPL570
Series:: GSE41485
8 Samples

Download data: CEL

DataSet

Accession:: GDS5094

ID:: 5094

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 1000005703.

[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 06, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site Complete coverage of the Human Genome U133 Set plus 6,500 additional genes for analysis of over 47,000 transcripts All probe sets represented on the GeneChip Human Genome U133 Set are identically replicated on the GeneChip Human Genome U133 Plus 2.0 Array. more...