GEO DataSets

(Submitter supplied) Global gene expression profiling has demonstrated that the predominant cellular response to a range of toxicants is a general stress response. This stereotyped environmental stress response commonly includes repression of protein synthesis and cell cycle regulated genes and induction of DNA damage and oxidative stress responsive genes. Our laboratory has recently characterized the general stress response of breast cell lines derived from basal-like and luminal epithelium following treatment with doxorubicin (DOX) or 5-fluorouracil (5FU) and showed that each cell type has a distinct response. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS1627

Platform:

GPL550

83 Samples

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Analysis of 4 breast cell lines treated for up to 36 hrs with the chemotherapeutic agents 5-fluorouracil (5FU), doxorubicin (DOX), or etoposide (ETOP), a drug mechanistically similar to DOX. Expression profiles for DOX- and 5FU-treated cells were used to successfully predict the response to ETOP.

Organism:

Homo sapiens

Type:

Expression profiling by array, log2 ratio, 4 agent, 4 cell line, 3 time sets

Platform:

GPL550

Series:

GSE1647

83 Samples

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(Submitter supplied) Recent studies have identified clinical subtypes of breast tumors that arise from different cell types and have different outcomes in response to chemotherapy. Tumors derived from basal epithelium have a poorer prognosis than tumors derived from luminal epithelium. To gain insight into differences underlying this disparity, we treated cell lines derived from basal epithelium (immortalized human mammary epithelial cells) and those derived from luminal epithelium (MCF-7 and ZR-75-1) with two chemotherapeutics commonly used in the treatment of breast cancer. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS845 GDS846 GDS847 GDS848

Platform:

GPL550

75 Samples

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Analysis of the response of luminal epithelium derived breast cancer line MCF-7 to either doxorubicin or 5-fluorouracil. Cells examined 12, 24, and 36 hours following treatment. Results provide insight into the response of breast cancers derived from different cell types to chemotherapeutics.

Organism:

Homo sapiens

Type:

Expression profiling by array, log ratio, 3 agent, 3 time sets

Platform:

GPL550

Series:

GSE763

19 Samples

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(Submitter supplied) Compugen oligo Catalog# HUMLIB96: Human OligoLibrary Release 1.0: 96 well format, 197 plates (18,861 oligos), plus about 1000 custom-designed oligos for Dr. Charles Perou's lab at University of North Carolina at Chapel Hill. Keywords = Breast Cancer Keywords = Chemotherapeutics Keywords = Gene expression Keywords = Microarray Keywords = Compugen

Organism:

Homo sapiens

5 DataSets

2 Series

83 Samples

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