GSM2293443[Accession] - GEO DataSets

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Items: 4

Select item 2000860951.

VHL deficiency drives enhancer activation of oncogenes in clear cell renal cell carcinoma

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:: GPL11154 GPL16791
195 Samples

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Series

Accession:: GSE86095

ID:: 200086095

PubMed Similar studies

Select item 2000860912.

cis-regulatory landscape in ccRCC [tissue]

(Submitter supplied) VHL loss is the most common genetic alteration event in ccRCC, but its effect on epigenetic landscape has not been elucidated previously. By performing histone modifications (H3K27ac, H3K4me1, H3K4me3) from ccRCC cell lines, we describe the genome-wide cis-regulatory landscapes of VHL-deficient ccRCC tumors. We show that ccRCCs exhibit a pervasive gain of enhancers around hypoxic and metabolic transcriptional targets.