GEO DataSets

(Submitter supplied) The immune protection against invading pathogens is governed by pathogen elimination (‘resistance’) and by limitation of tissue damage that results from host-pathogen interactions (‘tolerance’). However, distinct molecular states of resistance and tolerance remain obscure. Here, we collected longitudinal lung transcriptomes and clinical phenotypes of disease severity during influenza A virus (IAV) infection across 39 genetically-distinct mouse strains (32 strains of time series data and additional 7 strains with selected time points). Using transcriptional diversity in this data, we uncovered two key programs that together describe the cellular states for resistance and tolerance. more...

Organism:

Influenza A virus (A/Puerto Rico/8/1934(H1N1)); Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL30115

198 Samples

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