GEO DataSets

Analysis of fibroblasts expressing progerin (the mutant lamin A associated with progeria) or elevated levels of wildtype prelamin A. Cells subsequently reverted towards normal by farnesyltransferase inhibitor (FTI) or ZMPSTE24 treatment. Results identify potential effector of lamin A dysfunction.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 6 protocol sets

Platform:

GPL570

Series:

GSE40404

7 Samples

Download data: CEL

Analysis of blood from subjects administered orange juice w/o alcohol. Blood collected at time points corresponding to collection times for the alcohol group in GDS4938. These results, together with those from GDS4938, provide insight into molecular response of blood during acute ethanol exposure.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 5 individual, 2 protocol, 5 time sets

Platform:

GPL570

Series:

GSE20489

25 Samples

Download data: CEL

Analysis of chronic lymphocytic leukemia (CLL) cells treated with BV6, a Smac mimetic. CLL is characterized by B-lymphocyte accumulation, which is attributed to defective cell death. Inhibitor of apoptosis (IAP) proteins are highly expressed in CLL cells. Smac binds to and inhibits IAP proteins.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 agent, 4 genotype/variation, 4 individual, 2 other, 2 time sets

Platform:

GPL570

Series:

GSE62533

12 Samples

Download data: CEL

Analysis of retinal pigment epithelial ARPE-19 cells treated with SRPIN803, a small molecule inhibitor of serine-arginine protein kinase 1 SRPK1. SRPK1 inhibition prevents pathological angiogenesis. Results provide insight into the molecular mechanisms underlying the inhibitory activity of SRPIN803.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 agent sets

Platform:

GPL570

Series:

GSE62947

6 Samples

Download data: CEL

Analysis of proteasome inhibitor carfilzomib-resistant multiple myeloma (MM) cell lines KMS-11/Cfz and KMS-34/Cfz, after 1 week of growth in the absence of carfilzomib. Results provide insight into the molecular mechanisms underlying the acquisition of proteasome inhibitor resistance in MM.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 4 cell line, 2 cell type sets

Platform:

GPL570

Series:

GSE69078

12 Samples

Download data: CEL

Analysis of in vitro-generated dendritic cells (DCs) cultured with interleukin 17A (IL-17A) in the absence or presence of interferon-γ. IL-17A is involved in chronic inflammatory diseases. Results provide insight into the impact of IL-17A on DCs and the role of these DCs in inflammatory disease.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 3 protocol, 2 time sets

Platform:

GPL570

Series:

GSE53163

9 Samples

Download data: CEL

Analysis of DU145 xenograft tumors in NOD/SCID mice treated with NVP-BEZ235, taxotere, or both. NVP-BEZ235 targets prostate cancer progenitor cells. Taxotere targets the bulk tumor. Results provide insight into potential biomarkers associated with cancer stem cells in these xenograft tumors.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 4 agent sets

Platform:

GPL570

Series:

GSE49232

4 Samples

Download data: CEL

Analysis of U87 human xenograft tumors (in BALB/c SCID mouse host) treated with antiangiogenic agents bevacizumab (anti-VEGF) and dibenzazepine (anti-Notch). The tumors include mouse host stroma. Results, together with those from GDS5678, provide insight into molecular basis of tumor angiogenesis.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 3 agent sets

Platform:

GPL570

Series:

GSE39223

9 Samples

Download data: CEL

Analysis of HUVECs stimulated with two important angiogenic stimuli: peroxisome proliferator-activated receptor (PPAR) β/δ agonist and hypoxia. Results provide insight into possible synergistic molecular interactions between the PPAR β/δ and hypoxia-inducible factor (HIF) 1 signaling pathways.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 agent, 2 stress sets

Platform:

GPL570

Series:

GSE50378

4 Samples

Download data: CEL

Analysis of myoblasts isolated from a 7 year-old male and cultured in low-serum medium to stimulate myogenic differentiation for up 15 days. Results provide insight into the molecular mechanisms underlying myogenic differentiation.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 protocol, 4 time sets

Platform:

GPL570

Series:

GSE55034

4 Samples

Download data: CEL, CHP

Analysis of EVI1-overexpressing HL60 myeloid cells treated with ATRA. EVI1 overexpression is associated with poor prognosis in myeloid leukemias; ATRA is a myeloid differentiation inducing agent. Results provide insight into the potential interplay between EVI1 and ATRA in myeloid cells.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 agent, 2 genotype/variation sets

Platform:

GPL570

Series:

GSE66837

12 Samples

Download data: CEL

Analysis of EVI1-overexpressing U937 myeloid cells treated with ATRA. EVI1 overexpression is associated with poor prognosis in myeloid leukemias; ATRA is a myeloid differentiation inducing agent. Results provide insight into the potential interplay between EVI1 and ATRA in myeloid cells.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 agent, 2 genotype/variation sets

Platform:

GPL570

Series:

GSE66854

12 Samples

Download data: CEL

Analysis of gingival fibroblasts populating sponge-type or gel-type collagen scaffolds loaded with platelet-derived growth factor-BB. Collagen scaffolds augment oral soft tissue to support wound repair. Results provide insight into molecular basis of cell population dynamics of collagen scaffolds.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent, 2 growth protocol sets

Platform:

GPL570

Series:

GSE61314

4 Samples

Download data: CEL, CHP

Analysis of chimpanzee iPSCs generated from blood cells using Sendai virus vector TS12KOS which carries reprogramming factors KLF4, OCT3/4, and SOX2. TS12KOS was also used to establish human iPSCs from fibroblasts. Results examine differentially expressed genes between human and chimpanzee iPSCs.

Organism:

Pan troglodytes; Homo sapiens

Type:

Expression profiling by array, transformed count, 2 cell type, 5 individual, 2 species sets

Platform:

GPL570

Series:

GSE62572

7 Samples

Download data: CEL

Analysis of lymphoblastoid cell lines (LCLs), obtained from alcoholics, after treatment with ethanol in vitro. Results provide insight into the feasibility of using LCLs to study the molecular consequences of exposure to alcohol.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent, 2 disease state, 2 gender, 42 individual sets

Platform:

GPL570

Series:

GSE52553

84 Samples

Download data: CEL, CHP

Analysis of skin fibroblasts from Hutchinson Gilford Progeria Syndrome (HGPS) patients challenged by retroviral introduction of telomerase reverse transcriptase (TERT), V12-HRAS and SV40 large and small T antigens. Results provide insight into molecular basis of transformation resistance in HGPS.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 disease state, 4 individual, 2 protocol sets

Platform:

GPL570

Series:

GSE60518

8 Samples

Download data: CEL

Analysis of non-lesional and lesional psoriatic skins for up to 43 days following treatment with various doses of brodalumab, a human IgG2 mAb that selectively binds and blocks signaling through IL-17RA. Results provide insight into the molecular effect of blocking IL-17 signaling in psoriatic skin.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 3 agent, 4 dose, 25 individual, 4 time, 2 tissue sets

Platform:

GPL570

Series:

GSE53552

99 Samples

Download data: CEL

Analysis of highly glycolytic A549 lung cancer cells depleted for steroid receptor coactivator SRC-1 and grown in the absence of glucose. SRC-1 promotes gluconeogenesis and glycemia. Results provide insight into the role of SRC-1 in glycolytic cancer cells undergoing glucose deprivation.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 genotype/variation, 2 protocol sets

Platform:

GPL570

Series:

GSE56843

8 Samples

Download data: CEL

Analysis of undifferentiated H1 and H9 embryonic stem cell (ESC) lines and their differentiated embryoid bodies (EB). Result provide insight into those genes consistently altered during ESC differentiation.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 cell line, 2 protocol sets

Platform:

GPL570

Series:

GSE54186

8 Samples

Download data: CEL

Analysis of EOL-1 cells treated with imatinib mesylate (1uM, 6h). EOL-1 cells carry the platelet derived growth factor receptor α (PDGFRA)/FIP1L1 fusion and exhibit constitutive PDGFRA activation. Results provide insight into the molecular effects of inhibiting PDGFRA signaling by imatinib.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 agent sets

Platform:

GPL570

Series:

GSE53633

4 Samples

Download data: CEL