GEO DataSets

(Submitter supplied) Lassa fever virus is a zoonotic pathogen that plagues the endemic areas of West Africa. Rhesus macaques infected with a related arenavirus, LCMV-WE, serve as a model for Lassa-infection of human beings. Using a dose similar to that expected from a needle-stick, monkeys experience an early pre-viremic phase (day 1-3), a viremic phase with febrile onset (day 4-7), and, like human beings who succumb, they die within two weeks. more...

Organism:

Macaca mulatta; Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

24 Samples

Download data: CEL

(Submitter supplied) Microarray analysis of PBMC from cynomolgus macaques collected longitudinally over the course of infection with Lassa-Josiah, Lassa-Z132, Lassa-SorombaR, or Lujo viruses (n=3 animals/infection condition).

Organism:

Macaca fascicularis; Macaca mulatta

Type:

Expression profiling by array

Platform:

GPL14569

61 Samples

Download data: TXT

(Submitter supplied) Rhesus macaques (Macaca mulatta) infected with a lethal dose of lymphocytic choriomeningitis virus-strain WE (LCMV-WE) provide a model for Lassa fever virus infection of man. Like Lassa fever in human beings, disease begins with flu-like symptoms but can progress to morbidity fairly rapidly. Previously, we profiled the blood transcriptome of LCMV-infected monkeys (M. Djavani et al. J. Virol. 2007: PMID 17522210) showing distinct pre-viremic and viremic stages that discriminated between virulent and benign infections. more...

Organism:

Macaca mulatta; Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4161

Platform:

GPL570

20 Samples

Download data: CEL

Temporal analysis of liver from macaques infected with virulent lymphocytic choriomeningitis virus (LCMV)-WE or with non-virulent LCMV-Armstrong. LCMV-WE-infected macaques develop viral hemorrhagic fever similar to human Lassa fever. Results provide insight into molecular basis of LCMV pathogenesis.

Organism:

Macaca mulatta; Homo sapiens

Type:

Expression profiling by array, transformed count, 3 disease state, 4 infection, 11 time sets

Platform:

GPL570

Series:

GSE12254

20 Samples

Download data: CEL

(Submitter supplied) Lassa fever (LF) is a rodent-borne viral disease that can be fatal for human beings. In this study, an attenuated Lassa vaccine candidate, ML29, was tested in SIV-infected rhesus macaques for its ability to elicit immune responses without instigating signs of virulent disease. ML29 is a reassortant between Lassa and Mopeia viruses that causes a transient infection in non-human primates and confers sterilizing protection from lethal Lassa viral challenge. more...

Organism:

Macaca mulatta; Homo sapiens

Type:

Expression profiling by array; Third-party reanalysis

Platform:

GPL570

30 Samples

Download data: CEL

(Submitter supplied) Marburg virus is a genetically simple RNA virus that causes a severe hemorrhagic fever upon infection in humans and non-human primates. The mechanism of how this pathogenesis comes about is not well understood, but it is well accepted that pathogenesis is significantly driven by a hyperactive immune response. To better understand the overall response to Marburg virus challenge, we undertook a transcriptomic analysis of immune cells circulating in the blood following aerosol exposure of cynomolgus macaques to a lethal dose of Marburg virus. more...

Organism:

Macaca fascicularis; Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10332

30 Samples

Download data: TXT

(Submitter supplied) Lassa fever virus (LASV) is a significant human pathogen that is endemic to several countries in West Africa. Infection with Lassa leads to the development of hemorrhagic fever in a significant number of public health cases and it is considered a potential bioweapon. Little is known about the complex immune mechanisms governing response to LASV infection, or the genetic determinants of susceptibility and resistance to infection. more...

Organism:

Macaca fascicularis; Homo sapiens

Type:

Expression profiling by array

Platform:

GPL4133

30 Samples

Download data: TXT