GEO DataSets

(Submitter supplied) The obligate intracellular, gram-negative bacterium, Chlamydophila pneumoniae (Cpn), has impact as an acute and chronic disease-causing pathogen. Little is known about changes in the Cpn transcriptome during its biphasic developmental cycle (the acute infection) and persistence stages that are linked to chronic diseases. To analyze Cpn CWL029 gene expression, we designed a pathogen-specific oligo microarray and optimized the extraction method for pathogen RNA. more...

Organism:

Chlamydia pneumoniae

Type:

Expression profiling by array

Platform:

GPL4824

67 Samples

Download data: TXT, XML

(Submitter supplied) Transcriptional profiling of human epithelial cell line (HL) infected with Chlamydia penumoniae compared to control cells at time points 12h, 24h, 48h, 72h after the infection. Keywords: Chlamydia peneumoniae infection

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3360

Platform:

GPL887

8 Samples

Download data: GPR

Analysis of the HL epithelial cell line at various time points up to 72 hours following Chlamydia pneumoniae infection. C. pneumonia is a common cause of respiratory infections such as pneumonia. Results provide insight into host-cell phenomena that are affected at the different stages of infection.

Organism:

Homo sapiens

Type:

Expression profiling by array, log2 ratio, 4 time sets

Platform:

GPL887

Series:

GSE7246

8 Samples

Download data: GPR

(Submitter supplied) To understand the host transcriptional response to S. enterica serovar Choleraesuis (S. Choleraesuis), the first generation Affymetrix porcine GeneChip® was used to identify differentially expressed genes in the mesenteric lymph nodes responding to infection at acute (8 hours (h), 24h, 48h post-inoculation (pi)) and chronic stages (21 days (d) pi) The objectives of this study were to identify and examine the stereotypical gene expression response within the host mesenteric lymph nodes to S. more...

Organism:

Sus scrofa

Type:

Expression profiling by array

Platform:

GPL3533

15 Samples

Download data: CEL, EXP

(Submitter supplied) Purpose: The morphology of the RPE shows minimal change as the neural retina and choriocapillaris differentiate. Nonetheless, initial studies of barrier-related proteins suggest extensive remodeling of the RPE in response to this changing environment. A genomic approach was used to investigate the extent of this remodeling. Methods: RPE was isolated from E7, E10, E14 and E18 chick embryos and total RNA extracted for probing the entire genome on Affymetrix microarray chips. more...

Organism:

Gallus gallus

Type:

Expression profiling by array

Dataset:

GDS2964

Platform:

GPL3213

14 Samples

Download data: CEL, EXP

Analysis of retinal pigment epithelia (RPE) of E7 to E18 embryos. The RPE regulates transport between the neural retina and fenestrated capillaries of the choroid, a vascular layer between the retina and sclera. Results provide insight into the extent of remodeling of the RPE during development.

Organism:

Gallus gallus

Type:

Expression profiling by array, count, 4 development stage sets

Platform:

GPL3213

Series:

GSE7176

14 Samples

Download data: CEL, EXP

(Submitter supplied) We have utilized a high-density oligonucleotide microarray for catfish in order to study the transcriptomic responses of blue catfish following infection with E. ictaluri and to identify and develop important immune-related markers for future characterization and genetic mapping. Microarray analysis of the transcriptome profile of the blue catfish liver following infection with the Gram negative bacterium led to the identification of 103 differentially expressed transcripts. more...

Organism:

Ictalurus punctatus; Ictalurus furcatus

Type:

Expression profiling by array

Platform:

GPL4476

6 Samples

Download data: FTR

(Submitter supplied) Acute lymphoblastic leukemia (ALL) is an heterogeneous disease comprising several subentities that differ for both immunophenotypic and molecular characteristics. Over the years, the biologic understanding of this neoplasm has largely increased. Gene expression profiling has recently allowed to identify specific signatures for the different ALL subsets and permitted identification of pathways deregulated by a given lesion. more...

Organism:

Homo sapiens

Type:

Expression profiling by array; Non-coding RNA profiling by array

Platforms:

GPL570 GPL8191

39 Samples

Download data: CEL, XLS

(Submitter supplied) Recent whole-genome studies and in-depth expressed sequence tag (EST) analyses have identified most of the developmentally relevant genes in the urochordate, Ciona intestinalis. In this study, we made use of a large-scale oligo-DNA microarray to further investigate and identify genes with specific or correlated expression profiles. This large-scale oligo-DNA microarray for C. intestinalis should facilitate the understanding of global gene expression and gene networks during the development and ageing of a basal chordate. more...

Organism:

Ciona intestinalis

Type:

Expression profiling by array

Platform:

GPL4556

36 Samples

Download data

(Submitter supplied) Objective: It is unclear whether the host response of gram-positive sepsis differs from gram-negative sepsis at a transcriptome level. Using microarray technology, we compared the gene-expression profiles of gram-positive sepsis and gram-negative sepsis in critically ill patients. Design: A prospective cross-sectional study. Setting: A 20-bed general intensive care unit of a tertiary referral hospital. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3085

Platform:

GPL4274

72 Samples

Download data: GPR

Analysis of leukocytes from patients with gram-positive or gram negative sepsis. Results provide insight into the specificity of the host response to gram-positive and gram negative sepsis.

Organism:

Homo sapiens

Type:

Expression profiling by array, log ratio, 4 disease state sets

Platform:

GPL4274

Series:

GSE6535

72 Samples

Download data: GPR

(Submitter supplied) d-serine is naturally present throughout the human body. It is also used as add-on therapy for treatment-refractory schizophrenia. d-Serine interacts with the strychnine-insensitive glycine binding site of NMDA receptor, and this interaction could lead to potentially toxic activity (i.e., excitotoxicity) in brain tissue. The transcriptomic changes that occur in the brain after d-serine exposure have not been fully explored. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3643

Platform:

GPL1355

24 Samples

Download data: CEL

Analysis of forebrains of animals treated with up to 500 mg/kg D-serine for 96 hours. D-serine is involved in many physiological processes through its interaction with the glycine binding site of the NMDA receptor. Results provide insight into the impact of D-serine exposure on neuronal functions.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent, 6 dose sets

Platform:

GPL1355

Series:

GSE10748

24 Samples

Download data: CEL

(Submitter supplied) PURPOSE. Triamcinolone acetonide (TA) and dexamethasone (DEX) are corticosteroids commonly used for ocular inflammation but both can cause ocular hypertension. We investigated the differential gene expression profile of human trabecular meshwork (TM) cells in response to treatment by TA compared to that by DEX. METHODS. Total RNA was extracted from cultured human TM cells treated with TA or DEX and used for microarray gene expression analysis. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL4564

9 Samples

Download data

(Submitter supplied) This series represents the gene expression study of phages DT1 and 2972 during the whole process of infection. Gene expression was measured at nine time intervals (0, 2, 7, 12, 17, 22, 27, 32, 37 minutes) during phage infection. Keywords: time-course

Organism:

Brussowvirus bv2972; Moineauvirus DT1

Type:

Expression profiling by array

Platforms:

GPL1939 GPL2744

45 Samples

Download data

(Submitter supplied) Tumor tissue heterogeneity is a well known feature of several solid tumors. Neuroblastic Tumors (NTs) is a group of paediatric cancers with a great tissue heterogeneity. Most of NTs are composed of undifferentiated, poorly differentiated or differentiating neuroblastic (Nb) cells with very few or absent Schwannian stromal (SS) cells: these tumors are grouped as Neuroblastoma (Schwannian stroma-poor). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

28 Samples

Download data: CEL

(Submitter supplied) This microarray serie represents the complete gene expression study of bacteriophage BFK 20 during the infection of its host Brevibacterium flavum CCM 251. Keywords: time course

Organism:

Corynebacterium phage BFK20

Type:

Expression profiling by array

Platform:

GPL2741

14 Samples

Download data

(Submitter supplied) We investigated transcriptional response of CaCo-2 cells to iron treatments, we studied hemin effect by adding hemin to DMEM-FBS medium and iron deficiency effects in using an iron free medium compared to the same supplemented with FAC (ferric ammonium citrate). Keywords: various iron treatment, differential gene expression, hemin treatment, iron-free

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS2230

Platform:

GPL887

12 Samples

Download data

Analysis of intestinal CaCo-2 cell line grown in medium free of iron or supplemented with hemin to mimic iron overload. Intestinal iron absorption is crucial for systemic iron homeostasis. Results provide insight into molecular mechanisms regulating iron metabolism.

Organism:

Homo sapiens

Type:

Expression profiling by array, log10 ratio, 4 agent, 2 growth protocol sets

Platform:

GPL887

Series:

GSE3573

12 Samples

Download data

(Submitter supplied) Co-expression of genes that physically cluster together is a common characteristic of eukaryotic transcriptomes. Identifying these groups of co-expressed genes is important to the functional annotation of genomes and understanding the evolutionary fates of the clustered genes. We used microarrays to measure gene expression in seven closely related Drosophila species, to identify domains clusters within a species of Drosophila (D. more...

Organism:

Drosophila sechellia; Drosophila teissieri; Drosophila melanogaster; Drosophila mauritiana; Drosophila simulans; Drosophila yakuba; Drosophila santomea

Type:

Expression profiling by array

Platform:

GPL72

48 Samples

Download data: CEL