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| Status |
Public on Mar 08, 2008 |
| Title |
Expression data from brain tissue of Rattus norvegicus treated with D-Serine |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by array
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| Summary |
d-serine is naturally present throughout the human body. It is also used as add-on therapy for treatment-refractory schizophrenia. d-Serine interacts with the strychnine-insensitive glycine binding site of NMDA receptor, and this interaction could lead to potentially toxic activity (i.e., excitotoxicity) in brain tissue. The transcriptomic changes that occur in the brain after d-serine exposure have not been fully explored.
Affymetrix microarray technology was used to determine differential gene expression resulting from D-Serine exposure.
Keywords: Dose course
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| Overall design |
Male Fisher 344 rats aged 11-12 weeks were treated with various doses (0, 5, 20, 50, 200 & 500 mg/kg) of d-serine and terminally sacrificed 96 hours post-exposure. An approximate 30mg-section of the forebrain was processed for total RNA isolation.
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| Contributor(s) |
Chan VT, Davidson ME |
| Citation(s) |
19212759 |
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| Submission date |
Mar 06, 2008 |
| Last update date |
Jul 31, 2017 |
| Contact name |
Molly Davidson |
| E-mail(s) |
molly.davidson@wpafb.af.mil
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| Organization name |
AFRL/RHPB
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| Street address |
2729 R Street, Bldg 837
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| City |
WPAFB |
| State/province |
OH |
| ZIP/Postal code |
45433 |
| Country |
USA |
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| Platforms (1) |
| GPL1355 |
[Rat230_2] Affymetrix Rat Genome 230 2.0 Array |
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| Samples (24)
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| GSM271362 |
Exp A, Animal #243, control (0mg/kg) D-Serine |
| GSM271365 |
Exp A, Animal #244, control (0mg/kg) D-Serine |
| GSM271367 |
Exp A, Animal #245, control (0mg/kg) D-Serine |
| GSM271369 |
Exp A, Animal #246, control (0mg/kg) D-Serine |
| GSM271372 |
Exp A, Animal #267, 5mg/kg D-Serine |
| GSM271375 |
Exp A, Animal #269, 5mg/kg D-Serine |
| GSM271377 |
Exp A, Animal #270, 5mg/kg D-Serine |
| GSM271379 |
Exp A, Animal #271, 5mg/kg D-Serine |
| GSM271382 |
Exp A, Animal #262, 20mg/kg D-Serine |
| GSM271383 |
Exp A, Animal #263, 20mg/kg D-Serine |
| GSM271384 |
Exp A, Animal #265, 20mg/kg D-Serine |
| GSM271385 |
Exp A, Animal #266, 20mg/kg D-Serine |
| GSM271386 |
Exp A, Animal #257, 50mg/kg D-Serine |
| GSM271387 |
Exp A, Animal #258, 50mg/kg D-Serine |
| GSM271388 |
Exp A, Animal #259, 50mg/kg D-Serine |
| GSM271389 |
Exp A, Animal #261, 50mg/kg D-Serine |
| GSM271390 |
Exp A, Animal #253, 200mg/kg D-Serine |
| GSM271391 |
Exp A, Animal #254, 200mg/kg D-Serine |
| GSM271392 |
Exp A, Animal #255, 200mg/kg D-Serine |
| GSM271393 |
Exp A, Animal #256, 200mg/kg D-Serine |
| GSM271394 |
Exp A, Animal #247, 500mg/kg D-Serine |
| GSM271395 |
Exp A, Animal #248, 500mg/kg D-Serine |
| GSM271396 |
Exp A, Animal #249, 500mg/kg D-Serine |
| GSM271397 |
Exp A, Animal #251, 500mg/kg D-Serine |
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| Relations |
| BioProject |
PRJNA107529 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE10748_RAW.tar |
63.9 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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