GEO DataSets

(Submitter supplied) Introduction: microRNAs (miRNAs) are short non-coding RNAs that negatively regulate gene expression and may play a causal role in invasive breast cancer. Since many genetic aberrations of invasive disease are detectable in earlier stages, we hypothesized that miRNA expression dysregulation and the predicted changes in gene expression would also be found in early breast neoplasias. Methods: Expression profiling of 365 miRNAs by RT-qPCR was combined with laser-capture microdissection to obtain an epithelial specific miRNA expression signature of normal breast epithelium (n=9) and of paired samples of histologically normal epithelium (HN) and ductal carcinoma in situ (DCIS) (n=16). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

2 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array; Other

Platforms:

GPL96 GPL10349

21 Samples

Download data: CEL, TXT

(Submitter supplied) Introduction: microRNAs (miRNAs) are short non-coding RNAs that negatively regulate gene expression and may play a causal role in invasive breast cancer. Since many genetic aberrations of invasive disease are detectable in earlier stages, we hypothesized that miRNA expression dysregulation and the predicted changes in gene expression would also be found in early breast neoplasias. Methods: Expression profiling of 365 miRNAs by RT-qPCR was combined with laser-capture microdissection to obtain an epithelial specific miRNA expression signature of normal breast epithelium (n=9) and of paired samples of histologically normal epithelium (HN) and ductal carcinoma in situ (DCIS) (n=16). more...

Organism:

Homo sapiens

Type:

Other

Platform:

GPL10349

19 Samples

Download data: TXT

(Submitter supplied) To obtain insight into the molecular basis of ductal carcinoma in situ (DCIS) and its progression by infiltrating surrounding tissue, we have performed cellular-based gene expression analysis of pure DCIS and DCIS with co-existing invasive ductal carcinoma (IDC) and compared the histological and molecular aspects between these morphologically identical lesions seeking to find key genes involved in DCIS progression. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL1930

60 Samples

Download data

(Submitter supplied) Proliferative breast lesions, such as simple ductal hyperplasia (SH) and atypical ductal hyperplasia (ADH), are candidate precursors to ductal carcinoma in situ (DCIS) and invasive cancer. To better understand their relationship to more advanced disease, we used microdissection and DNA microarrays to profile the gene expression of patient-matched histologically normal (HN), ADH, and DCIS from 12 patients with ER+ sporadic breast cancer. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

40 Samples

Download data: CEL

(Submitter supplied) we describe a mRNA profiling analysis of matched ductal carcinoma in situ and invasive duct carcinoma components of FFPE breast carcinomas with the purpose to identify potential prognostic markers

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL8432

42 Samples

Download data: TXT

(Submitter supplied) To identify differentially expressed genes in human brest cancer specimens were subjected to Agilent whole genome microarrays.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL20844

4 Samples

Download data: TXT

(Submitter supplied) Altered expression of microRNAs (miRNAs), an abundant class of small non-protein-coding RNAs that mostly function as negative regulators of protein-coding gene expression, is common in cancer. Here we analyze the regulation of miRNA expression in response to estrogen, a steroid hormone that is involved in the development and progression of breast carcinomas and that is acting via the estrogen receptors (ER) transcription factors. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL5175

9 Samples

Download data: CEL

(Submitter supplied) To better understand the role of tumor microenvironment in breast cancer progression, we combined laser capture microdissection and microarray analysis to provide a comprehensive catalog of gene expression changes in both tumor and tumor-associated stroma. Keywords: cancer vs. normal

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL1352

66 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL1352 GPL8300

126 Samples

Download data: CEL

(Submitter supplied) We used gene expression profiling of human DCIS and IBC to discover uniquely expressed genes that may also regulate progression.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL1352

22 Samples

Download data: CEL, TXT

(Submitter supplied) We used gene expression profiling of human DCIS and IBC to discover uniquely expressed genes that may also regulate progression.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL1352

22 Samples

Download data: CEL, TXT

(Submitter supplied) We used gene expression profiling of human DCIS and IBC to discover uniquely expressed genes that may also regulate progression.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL8300

18 Samples

Download data: CEL, TXT

(Submitter supplied) We used gene expression profiling of human DCIS and IBC to discover uniquely expressed genes that may also regulate progression.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL8300

14 Samples

Download data: CEL, TXT

(Submitter supplied) We used gene expression profiling of human DCIS and IBC to discover uniquely expressed genes that may also regulate progression.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL8300

50 Samples

Download data: CEL, TXT

(Submitter supplied) Analysis of gene expression changes in tumour epithelium (DCIS and invasive breast cancer) and stroma both immediately surrounding the lesions and more distantly.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6883

67 Samples

Download data: TXT

(Submitter supplied) This study takes an unbiased global analysis of super-enhancers that are acquired or lost in progression of breast cancer using the MCF10a progression series

Organism:

Homo sapiens

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL18573

16 Samples

Download data: BEDGRAPH

(Submitter supplied) BHLHE40-AS1 was cloned into pBABE-Puro. Empty vector and pBABE-BHLHE40-AS1 were used to generate retrovirus and infect MCF10A cells. Transduced cells were selected with 1ug/mL puromycin for 2 weeks.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL24539

6 Samples

Download data: CEL, CHP

(Submitter supplied) Tandem DCIS/IDC are defined as ductal carcicnoma in situ (DCIS) lesions that have concurrent invasive ductal carcinoma (IDC) within the same breast. These are identified radiologically by an area of clustered microcalcifications adjacent to (contiguous with) an invasive mass. Our radiologist (Dr. William P. Smith) has provided us with biopsy cores from each region. One core from each region (DCIS and IDC) has bas been collected and subjected to RNA sequencing for our studies to compare changes from DCIS to IDC in each individual patient.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL16791

12 Samples

Download data: XLSX

(Submitter supplied) Using a mimic miR-200c was restored to an aggressive, Type 2 endometrial cancer cell line, Hec50

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

9 Samples

Download data: CEL