GEO DataSets

(Submitter supplied) Ductal carcinoma in situ (DCIS) is a non-obligate precursor to invasive ductal carcinoma (IDC). Annotation of the genetic differences between the two lesions may assist in the identification of genes that promote the invasive phenotype. Matched IDC and DCIS showed highly similar copy number profiles (average of 83% of the genome shared) indicating a common clonal orgin although there is evidence that the DCIS continues to evolve in parallel with the co-existing IDC. more...

Organism:

Homo sapiens

Type:

Genome variation profiling by SNP array

Platform:

GPL13270

42 Samples

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(Submitter supplied) To obtain insight into the molecular basis of ductal carcinoma in situ (DCIS) and its progression by infiltrating surrounding tissue, we have performed cellular-based gene expression analysis of pure DCIS and DCIS with co-existing invasive ductal carcinoma (IDC) and compared the histological and molecular aspects between these morphologically identical lesions seeking to find key genes involved in DCIS progression. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL1930

60 Samples

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(Submitter supplied) cDNA aCGH study of pure DCIS (breast duct carcinoma in situ) without invasive tumor, DCIS associated with IDC (breast invasive duct carcinoma) and its IDC component 23 patients: 6 pure DCIS without invasive cancer and no history of invasive cancer, 17 DCIS associated with IDC. Out of the latter 1 tumor had only enough DCIS (#16) for aCGH and one - IDC (#23) Keywords: Comparative clinical study

Organism:

Homo sapiens

Type:

Genome variation profiling by array

Platform:

GPL6382

38 Samples

Download data: GPR, TXT

(Submitter supplied) Analysis of gene expression changes in tumour epithelium (DCIS and invasive breast cancer) and stroma both immediately surrounding the lesions and more distantly.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6883

67 Samples

Download data: TXT

(Submitter supplied) This is a matched-pair analysis of ductal carcinoma in situ (DCIS) and invasive component (IDC) of nine breast ductal carcinoma to identify novel molecular markers characterizing the transition from DCIS to IDC for a better understanding of its molecular biology. Keywords: Affymetrix-based Microarrays in Mamma carcinoma

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS2045 GDS2046

Platforms:

GPL570 GPL96

24 Samples

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Analysis of preinvasive ductal carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC) tumors. Pairs of patient-matched DCIS and IDC tumor specimens analyzed. Results provide insight into the mechanisms underlying the progression of DCIS to IDC.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 disease state, 7 individual sets

Platform:

GPL570

Series:

GSE3893

14 Samples

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Analysis of preinvasive ductal carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC) tumors. Pairs of patient-matched DCIS and IDC tumor specimens analyzed. Results provide insight into the mechanisms underlying the progression of DCIS to IDC.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 disease state, 5 individual sets

Platform:

GPL96

Series:

GSE3893

10 Samples

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(Submitter supplied) we describe a mRNA profiling analysis of matched ductal carcinoma in situ and invasive duct carcinoma components of FFPE breast carcinomas with the purpose to identify potential prognostic markers

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL8432

42 Samples

Download data: TXT

(Submitter supplied) Ductal carcinoma in situ (DCIS) is a non-invasive form of breast cancer where cells restricted to the ducts exhibit an atypical phenotype. Some DCIS lesions are believed to rapidly transit to invasive ductal carcinomas (IDCs), while others remain unchanged. Existing classification systems for DCIS fail to identify those lesions that transit to IDC. We studied gene expression patterns of 31 pure DCIS, 36 pure invasive cancers and 42 cases of mixed diagnosis (invasive cancer with an in situ component) using Agilent Whole Human Genome Oligo Microarrays 44k. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6848

115 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL8300 GPL1352

126 Samples

Download data: CEL

(Submitter supplied) We used gene expression profiling of human DCIS and IBC to discover uniquely expressed genes that may also regulate progression.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL1352

22 Samples

Download data: CEL, TXT

(Submitter supplied) We used gene expression profiling of human DCIS and IBC to discover uniquely expressed genes that may also regulate progression.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL1352

22 Samples

Download data: CEL, TXT

(Submitter supplied) We used gene expression profiling of human DCIS and IBC to discover uniquely expressed genes that may also regulate progression.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL8300

18 Samples

Download data: CEL, TXT

(Submitter supplied) We used gene expression profiling of human DCIS and IBC to discover uniquely expressed genes that may also regulate progression.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL8300

14 Samples

Download data: CEL, TXT

(Submitter supplied) We used gene expression profiling of human DCIS and IBC to discover uniquely expressed genes that may also regulate progression.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL8300

50 Samples

Download data: CEL, TXT

(Submitter supplied) Whole-genome BAC-array. Isolated BAC-DNA was amplified by two-step DOP-PCR. PCR products were dissolved in 3xSSC, 1.5M betaine and spotted as triplicates on epoxysilane-coated slides. Keywords = Matrix-CGH Keywords = array-CGH

Organism:

Homo sapiens

1 Series

94 Samples

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(Submitter supplied) Genomic alterations during the in situ to invasive ductal breast carcinoma transition shaped by the immune system

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL16791

10 Samples

Download data: CSV

(Submitter supplied) This study takes an unbiased global analysis of super-enhancers that are acquired or lost in progression of breast cancer using the MCF10a progression series

Organism:

Homo sapiens

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL18573

16 Samples

Download data: BEDGRAPH

(Submitter supplied) Ductal carcinoma in situ (DCIS) is a precursor lesion that can give rise to invasive breast cancer (IBC). It has been proposed that both the nature of the lesion and the tumor microenvironment play key roles in progression to IBC. Here, laser capture microdissected tissue samples from epithelium and stroma in normal breast, pure DCIS, and pure IBC were employed to define key gene expression profiles associated with disease progression.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL5175

45 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below. Description of samples employed for the subseries NGS analyses including age, race, ER/PR immunohistochemistry results, ITIL/STIL scores and PAM50 classification is provided in the 'Supplementary Data1_Samples data.xlsx'.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing

Platform:

GPL11154

64 Samples

Download data: XLSX