Similar studies for GEO DataSets (Select 200040843) - GEO DataSets

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Items: 20

Select item 2000408431.

Differentially expressed miRNAs in TGF-β1-knock down rhabdmyosarcoma cell lines vs controls

(Submitter supplied) To investigate the role of TGF-β1-regulated miRNAs in the progression of RMS,we performed comprehensive miRMA microarray analysis on RNA derived from typical RMS cell lines and TGF-β1 knock-down cell lines. We identified a novel set of TGF-β1-related miRNAs.

Organism:: Mus musculus; Rattus norvegicus; Murid betaherpesvirus 1; JC polyomavirus; Human immunodeficiency virus 1; Mus musculus cytomegalovirus 2; Betapolyomavirus macacae; Human gammaherpesvirus 8; Merkel cell polyomavirus; Homo sapiens; Human alphaherpesvirus 1; Human betaherpesvirus 5; human gammaherpesvirus 4; Betapolyomavirus hominis; Human alphaherpesvirus 2; Murid gammaherpesvirus 4

Type:: Non-coding RNA profiling by array

Platform:: GPL11434
6 Samples

Download data: TXT

Series

Accession:: GSE40843

ID:: 200040843

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Select item 2001251832.

Next Generation Sequencing Analysis of miRNA profiling in fibroblast or myofibroblast

(Submitter supplied) We reported the application of next generation sequencing technology for high-throughput profiling of miRNA expression in human primary lung fibroblast Cells with undifferentiated (fibroblast) or differentiated (myofibroblast) status. By comparation the expression aboundence of known miRNAs between undifferentiated and differentiated type human primary lung fibroblast cells, we found both upregulated and downregulated miRNAs in fibroblast cells during differentiation. more...

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL18573
8 Samples

Download data: TXT

Series

Accession:: GSE125183

ID:: 200125183

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000331403.

Human bone marrow precursor cells

(Submitter supplied) The aim of this study was to characterize in vivo miRNA expression in normal myeloid development of the neutrophil granulocyte (granulopoiesis) to gain insight into miRNA control of these processes. Cell populations highly enriched in precursors from successive stages of granulopoiesis and mature neutrophils were isolated from bone marrow (BM) and peripheral blood (PB) samples, respectively, from 4 healthy human donors. more...

Organism:: Homo sapiens; Human alphaherpesvirus 1; Human betaherpesvirus 5; human gammaherpesvirus 4; Betapolyomavirus macacae; Mus musculus; Murid betaherpesvirus 1; JC polyomavirus; Human immunodeficiency virus 1; Human gammaherpesvirus 8; Rattus norvegicus; Murid gammaherpesvirus 4; Betapolyomavirus hominis

Type:: Non-coding RNA profiling by array

Platform:: GPL13273
16 Samples

Download data: GPR

Series

Accession:: GSE33140

ID:: 200033140

Select item 2000821294.

PAX7 is a required target for microRNA-206-induced differentiation of fusion-negative rhabdomyosarcoma

(Submitter supplied) Genes regulated by miR-206 were identified by microarray analysis in RD cells transfected with a Negative Control (NC) or miR-206 Mimic

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL16686
8 Samples

Download data: CEL

Series

Accession:: GSE82129

ID:: 200082129

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Select item 2001034645.

Gene expression profile (GEP) of miR-382-5p-overexpressing CD34+ cells

(Submitter supplied) Primary Myelofibrosis (PMF) is a Philadelphia negative chronic myeloproliferative neoplasm characterized by bone marrow fibrosis, enhanced oxidative stress and high levels of serum pro-inflammatory cytokines. To identify genes and miRNAs potentially involved in PMF pathogenesis, we have previously carried out an integrative analysis of gene and microRNA expression profiles of PMF hematopoietic stem cells (HSPCs), which allowed us to identify miR-382-5p as up-regulated miRNA (Norfo R. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13667
6 Samples

Download data: CEL

Series

Accession:: GSE103464

ID:: 200103464

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Select item 2000975536.

PAX3-FOXO1 regulated microRNAs contribute to the pathogenesis of alveolar rhabdomyosarcoma

(Submitter supplied) Interrogation of microRNA expression and regulation by PAX3-FOXO1 in Fusion-Positive Rhabdomyosarcoma.

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL19730
25 Samples

Download data: TXT

Series

Accession:: GSE97553

ID:: 200097553

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Select item 2001371687.

Liaison between SNAI2 and MYOD enhances oncogenesis and suppresses differentiation in Fusion-Negative Rhabdomyosarcoma

(Submitter supplied) Rhabdomyosarcoma (RMS) is a pediatric malignancy of mesenchymal origin. Fusion Negative-RMS (FN-RMS) tumors are associated with RAS-pathway activation. RMS tumors express pro-differentiation myogenic transcription factors MYOD and MYOG, yet why they are unable to differentiate is poorly understood. Here we show that SNAI2 is highly expressed in FN-RMS, is regulated by MYOD and blocks myogenic differentiation promoting growth. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing; Other

Platform:: GPL18573
22 Samples

Download data: HIC, NARROWPEAK, TXT

Series

Accession:: GSE137168

ID:: 200137168

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Select item 2001882368.

TGF-β Induction of miR-143/145 Is Associated to Exercise Response by Influencing Differentiation and Insulin Signaling Molecules in Human Skeletal Muscle

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing

Platform:: GPL16791
30 Samples

Download data: TXT

Series

Accession:: GSE188236

ID:: 200188236

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Select item 2001882359.

TGF-β-induced miR143/145 influences differentiation, insulin signaling and exercise response in human skeletal muscle [small RNA-seq]

(Submitter supplied) Physical training improves insulin sensitivity and can prevent type 2 diabetes. However, approximately 20% of individuals lack a beneficial outcome in glycemic control. TGF-β, identified as a possible upstream regulator involved in this low response is also a potent regulator of microRNAs (miRs). Aim of this study was to elucidate the potential impact of TGF-β-driven miRNAs on individual exercise response. more...

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL16791
15 Samples

Download data: TXT

Series

Accession:: GSE188235

ID:: 200188235

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Select item 20018823410.

TGF-β-induced miR143/145 influences differentiation, insulin signaling and exercise response in human skeletal muscle [RNA-seq]

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
15 Samples

Download data: TXT

Series

Accession:: GSE188234

ID:: 200188234

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Select item 20015235511.

ChIP-seq analysis of SNAIL transcription factor binding sites in RH30 rhabdomyosarcoma cells

(Submitter supplied) ChIP-seq analysis of SNAIL binding sites in RH30 cells was performed to discover novel SNAIL binding sites in rhabdmyosarcoma cells.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL16791
2 Samples

Download data: XLS

Series

Accession:: GSE152355

ID:: 200152355

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20010011412.

The effect of SNAIL transcription factor on microRNA transcriptome in rhabdomyosarcoma

(Submitter supplied) The main goal of the project was to analyze the effect of SNAIL transcription factor on microRNA expression profile in rhabdomyosarcoma (RMS) cells using the next generation sequencing. Differential expression of microRNAs between three groups was compared in RH30 alveolar RMS cells: WT (WT), shCTRL (modified with control shRNA vector) and shSNAIL (modified with shRNA against SNAIL). Different groups were compared to investigate the effect of SNAIL silencing on microRNA up- or downregulation.

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL18573
9 Samples

Download data: TSV

Series

Accession:: GSE100114

ID:: 200100114

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Select item 20009876913.

MiRNA expression variation in primary NK cells treated with TGF-β1

(Submitter supplied) Human NK cells activity against cancer cells is deeply suppressed by TGF-β1, an immunomodulatory cytokine that is released and activated in the tumor microenvironment. Moreover, our previous data showed that TGF-β1 modifies the chemokine receptor repertoire of NK cells. In particular, it decreases the expression of CX3CR1 that drives these effectors toward peripheral tissues, including tumor sites. In order to identify possible mechanisms mediating chemokine receptors modulation, we analyzed the miRNA profile of TGF-β1-treated primary NK cells. The analysis pointed out miR-27a-5p as a possible modulator of CX3CR1. We demonstrated the functional interaction of miR-27a-5p with the 3’ untranslated region (3’UTR) of CX3CR1 mRNA by two different experimental approaches: by the use of a luciferase assay based on a reporter construct containing the CX3CR1 3’UTR and by transfection of primary NK cells with a miR-27a-5p inhibitor. We also showed that the TGF-β1-mediated increase of miR-27a-5p expression is a consequence of miR-23a-27a-24-2 cluster induction. Moreover, we demonstrated that miR-27a-5p down-regulates the surface expression of CX3CR1. Finally we showed that Neuroblastoma cells induced in resting NK cells a downregulation of the CX3CR1 expression that was paralleled by a significant increase of miR-27a-5p expression. Therefore, the present study highlights miR-27a-5p as a pivotal TGF-β1-induced regulator of CX3CR1 expression.

Organism:: Homo sapiens

Type:: Expression profiling by RT-PCR

Platform:: GPL18942
9 Samples

Download data: TXT

Series

Accession:: GSE98769

ID:: 200098769

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Select item 20005267914.

microRNA-27a contributes to rhabdomyosarcoma cell proliferation through suppression of RARA and RXRA

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below. Background: Rhabdomyosarcomas (RMS) are rare but very aggressive tumors of childhood that arise as a consequence of regulatory distruption of the growth and differentiation pathways of myogenic precursor cells. Based on morphology, two major RMS subtypes can be identified: embryonal RMS (ERMS) and alveolar (ARMS). So, it is essential to unravel the molecular mechanisms involved in cancer pathogenesis and in disease progression. more...

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by array; Non-coding RNA profiling by array

Platforms:: GPL6480 GPL17835
22 Samples

Download data: CSV, TXT

Series

Accession:: GSE52679

ID:: 200052679

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Select item 20005267815.

Gene expression profiling of miR27a over-expressing RH36 cell lines.

(Submitter supplied) In order to identify direct or indirect miR-27a modulated genes, RH36 cells transfected with miR-27a precursors (pre-miR-27a or pre-control), analyzed 48h post-transfection, were used to perform microarray analysis.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6480
6 Samples

Download data: TXT

Series

Accession:: GSE52678

ID:: 200052678

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Select item 20005267716.

miRNA expression profiling in rhabdomyosarcoma cell lines

(Submitter supplied) Rhabdomyosarcomas (RMS) are rare but very aggressive tumours of childhood that arise as a consequence of regulatory disruption of the growth and differentiation pathways of myogenic precursor cells. Based on morphology, two major RMS subtypes can be identified: embryonal RMS (ERMS) and alveolar (ARMS). To better understand the global function of miRNA in RMS, we analyzed the expression profile of 8 different RMS cell lines (3 PAX3/FOXO1 positive and 5 PAX3/FOXO1 negative RMS) using the mirVana miRNA Probe Set V1 (Ambion). more...

Organism:: Homo sapiens; Mus musculus

Type:: Non-coding RNA profiling by array

Platform:: GPL17835
16 Samples

Download data: CSV

Series

Accession:: GSE52677

ID:: 200052677

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Select item 20020717017.

TWIST2-Mediated Chromatin Remodeling Promotes Fusion-Negative Rhabdomyosarcoma.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Mus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:: GPL16791 GPL23693 GPL18573
42 Samples

Download data: BED, BIGWIG, TXT

Series

Accession:: GSE207170

ID:: 200207170

PubMed Full text in PMC Similar studies

Select item 20020716818.

TWIST2-Mediated Chromatin Remodeling Promotes Fusion-Negative Rhabdomyosarcoma [RNA-seq Xenograft]

(Submitter supplied) Sarcomas are derailed in pathways that specify mesenchymal lineages during embryogenesis, causing tumor cells to stall at early stages of differentiation. Among them, rhabdomyosarcoma (RMS) is a pediatric soft tissue sarcoma of skeletal muscle origin. A key feature of RMS is their inability to terminally differentiate despite the high expression of master myogenic regulator MYOD. The bHLH transcription factor TWIST2, which governs mesenchymal stem cell identity and restricts myogenesis, is overexpressed in patient fusion-negative RMS (FN-RMS) tumors. more...