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Links from GEO DataSets

Items: 14

1.

Transcriptional comparison of cynomolgus macaques (Macaca fascicularis) following infection with Lassa or Lujo viruses

(Submitter supplied) Microarray analysis of PBMC from cynomolgus macaques collected longitudinally over the course of infection with Lassa-Josiah, Lassa-Z132, Lassa-SorombaR, or Lujo viruses (n=3 animals/infection condition).
Organism:
Macaca fascicularis; Macaca mulatta
Type:
Expression profiling by array
Platform:
GPL14569
61 Samples
Download data: TXT
Series
Accession:
GSE49838
ID:
200049838
2.

An attenuated Lassa vaccine in SIV-infected rhesus macaques does not persist or cause renavirus disease but does elicit protective immunity

(Submitter supplied) Lassa fever (LF) is a rodent-borne viral disease that can be fatal for human beings. In this study, an attenuated Lassa vaccine candidate, ML29, was tested in SIV-infected rhesus macaques for its ability to elicit immune responses without instigating signs of virulent disease. ML29 is a reassortant between Lassa and Mopeia viruses that causes a transient infection in non-human primates and confers sterilizing protection from lethal Lassa viral challenge. more...
Organism:
Macaca mulatta; Homo sapiens
Type:
Expression profiling by array; Third-party reanalysis
Platform:
GPL570
30 Samples
Download data: CEL
Series
Accession:
GSE33687
ID:
200033687
3.

Primate blood signs of arenavirus hemorrhagic fever

(Submitter supplied) Lassa fever virus is a zoonotic pathogen that plagues the endemic areas of West Africa. Rhesus macaques infected with a related arenavirus, LCMV-WE, serve as a model for Lassa-infection of human beings. Using a dose similar to that expected from a needle-stick, monkeys experience an early pre-viremic phase (day 1-3), a viremic phase with febrile onset (day 4-7), and, like human beings who succumb, they die within two weeks. more...
Organism:
Macaca mulatta; Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
24 Samples
Download data: CEL
Series
Accession:
GSE5790
ID:
200005790
4.

Transcriptional Profiling in Non-Human Primates Infected With Lassa Virus to Understand the Immune Response to Lassa Infection

(Submitter supplied) Lassa fever virus (LASV) is a significant human pathogen that is endemic to several countries in West Africa. Infection with Lassa leads to the development of hemorrhagic fever in a significant number of public health cases and it is considered a potential bioweapon. Little is known about the complex immune mechanisms governing response to LASV infection, or the genetic determinants of susceptibility and resistance to infection. more...
Organism:
Macaca fascicularis; Homo sapiens
Type:
Expression profiling by array
Platform:
GPL4133
30 Samples
Download data: TXT
Series
Accession:
GSE41752
ID:
200041752
5.

Transcriptome Analysis of Human Peripheral Blood Mononuclear Cells Exposed to Lassa Virus and to the Reassortant ML29, a Vaccine Candidate

(Submitter supplied) The virulent Lassa fever virus (LASV) and the non-pathogenic Mopeia virus (MOPV) infect rodents and incidentally people in West Africa. The mechanism of LASV damage in human beings is unclear. A live-attenuated reassortant of MOPV and LASV protects rodents and primates from Lassa fever disease. Peripheral blood mononuclear cells from healthy human subjects were expose to either LASV or ML29 in order to identify early cellular responses that could be attributed to the difference in virulence between both viruses. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS5058
Platform:
GPL570
27 Samples
Download data: CEL
Series
Accession:
GSE41300
ID:
200041300
6.
Full record GDS5058

Peripheral blood mononuclear cells response to Lassa Virus and Mopeia/Lassa reassortant 29: time course

Analysis of PBMCs exposed in vitro to LASV or ML29 viruses and collected up to 24 hrs post-exposure. The ML29 vaccine candidate is derived from Lassa and Mopeia viruses and protects against Lassa fever disease. Results provide insight into LASV-induced pathology and mechanisms of attenuation.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 3 dose, 3 protocol sets
Platform:
GPL570
Series:
GSE41300
27 Samples
Download data: CEL
7.

Transcriptional Profiling of the Immune Response to Marburg Infection

(Submitter supplied) Marburg virus is a genetically simple RNA virus that causes a severe hemorrhagic fever upon infection in humans and non-human primates. The mechanism of how this pathogenesis comes about is not well understood, but it is well accepted that pathogenesis is significantly driven by a hyperactive immune response. To better understand the overall response to Marburg virus challenge, we undertook a transcriptomic analysis of immune cells circulating in the blood following aerosol exposure of cynomolgus macaques to a lethal dose of Marburg virus. more...
Organism:
Macaca fascicularis; Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10332
30 Samples
Download data: TXT
Series
Accession:
GSE58287
ID:
200058287
8.

Balanced immunity to Lassa virus glycoprotein and nucleoprotein is associated with full protection of macaques after a single shot of different vaccines

(Submitter supplied) Lassa fever is a major threat in Western Africa. The large number of people living at risk for this disease calls for the development of a vaccine against Lassa virus (LASV). We compared the efficacy of measles-based and Mopeia-based vaccine platforms against LASV in cynomolgus monkeys. The vaccines were well tolerated and protected the animals from Lassa virus infection and disease after a single immunization but with different efficacy. more...
Organism:
Macaca fascicularis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL22523
71 Samples
Download data: CSV
Series
Accession:
GSE132998
ID:
200132998
9.

Gene expression associated with liver metabolism during viral hemorrhagic fever

(Submitter supplied) Rhesus macaques (Macaca mulatta) infected with a lethal dose of lymphocytic choriomeningitis virus-strain WE (LCMV-WE) provide a model for Lassa fever virus infection of man. Like Lassa fever in human beings, disease begins with flu-like symptoms but can progress to morbidity fairly rapidly. Previously, we profiled the blood transcriptome of LCMV-infected monkeys (M. Djavani et al. J. Virol. 2007: PMID 17522210) showing distinct pre-viremic and viremic stages that discriminated between virulent and benign infections. more...
Organism:
Macaca mulatta; Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4161
Platform:
GPL570
20 Samples
Download data: CEL
Series
Accession:
GSE12254
ID:
200012254
10.
Full record GDS4161

Nonhuman primate model of Lassa fever: liver

Temporal analysis of liver from macaques infected with virulent lymphocytic choriomeningitis virus (LCMV)-WE or with non-virulent LCMV-Armstrong. LCMV-WE-infected macaques develop viral hemorrhagic fever similar to human Lassa fever. Results provide insight into molecular basis of LCMV pathogenesis.
Organism:
Macaca mulatta; Homo sapiens
Type:
Expression profiling by array, transformed count, 3 disease state, 4 infection, 11 time sets
Platform:
GPL570
Series:
GSE12254
20 Samples
Download data: CEL
11.

Host response to smallpox

(Submitter supplied) Smallpox has played an unparalleled role in human history and remains a significant potential threat to public health. Despite the historical significance of this disease, we know little about the underlying pathophysiology or the virulence mechanisms of the causative agent, variola virus. To improve our understanding of variola pathogenesis and variola-host interactions, we examined the molecular and cellular features of hemorrhagic smallpox in cynomolgus macaques. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL3347 GPL3093 GPL3346
167 Samples
Download data
Series
Accession:
GSE4013
ID:
200004013
12.

Rapid protection induced by a single-shot Lassa vaccine in cynomolgus monkeys

(Submitter supplied) Lassa fever outbreaks hit West African countries every year and there is still no licensed vaccine to limit the burden of this viral hemorrhagic fever. We previously developed MeV-NP, a single-shot vaccine that induces protective immunity in cynomolgus monkeys one month or more than a year before Lassa virus infection and that is able to protect against divergent viral strains. Given the limited dissemination area of Lassa virus during outbreaks and the high risk of nosocomial transmission, a vaccine that induces rapid protection could be useful to protect exposed people during outbreaks in the absence of preventive vaccination. more...
Organism:
Macaca fascicularis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL22523
51 Samples
Download data: CSV
Series
Accession:
GSE225258
ID:
200225258
13.

Comparison of Transcriptomic Platform for Analysis of Whole Blood from Ebola-Infected Cynomolgus Macaques

(Submitter supplied) Ebola virus disease (EVD) is a serious illness associated with 20-90% fatalities. EVD is characterized by robust virus replication and strong host inflammatory immune response. Analyzing the host immune response has increasingly involved multimodal approaches including transcriptomics to profile gene expression. We studied cynomolgus macaques exposed to Ebola virus (EBOV) Makona via different routes with the intent of comparing RNA-Seq to a NanoString nCounter codeset targeting 769 non-human primate (NHP) genes. more...
Organism:
Macaca fascicularis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20302
21 Samples
Download data: TXT
Series
Accession:
GSE99463
ID:
200099463
14.

Longitudinal analysis of the group A Streptococcus transcriptome

(Submitter supplied) Identification of the genetic events that contribute to host-pathogen interactions is important for understanding the natural history of infectious diseases and developing therapeutics. Transcriptome studies conducted on pathogens have been central to this goal in recent years. However, most of these investigations have focused on specific end points or disease phases, rather than analysis of the entire time course of infection. more...
Organism:
Coxiella burnetii; Streptococcus pyogenes; Yersinia pestis; Macaca fascicularis; Borreliella burgdorferi; Chlamydia trachomatis; Staphylococcus aureus
Type:
Expression profiling by array
Platform:
GPL2129
259 Samples
Download data: CEL, EXP, TXT
Series
Accession:
GSE2713
ID:
200002713
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