GEO DataSets

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Plasmodium berghei ANKA; Plasmodium berghei

Type:

Expression profiling by array; Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:

GPL18820 GPL15092 GPL18821

17 Samples

Download data: TXT

(Submitter supplied) Stage-specific transcription is a fundamental biological process in the lifecycle of the Plasmodium parasite. Proteins containing the AP2 DNA-binding domain are responsible for stage-specific transcriptional regulation, and belong to the only known family of transcription factors in Plasmodium parasites. A comprehensive identification of their target genes will advance our understanding of the molecular basis of stage-specific parasite development. more...

Organism:

Plasmodium berghei

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL18820

2 Samples

Download data: TXT

(Submitter supplied) Stage-specific transcription is a fundamental biological process in the lifecycle of the Plasmodium parasite. Proteins containing the AP2 DNA-binding domain are responsible for stage-specific transcriptional regulation, and belong to the only known family of transcription factors in Plasmodium parasites. A comprehensive identification of their target genes will advance our understanding of the molecular basis of stage-specific parasite development. more...

Organism:

Plasmodium berghei

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL18821

2 Samples

Download data: TXT

(Submitter supplied) Stage-specific transcription is a fundamental biological process in the lifecycle of the Plasmodium parasite. Proteins containing the AP2 DNA-binding domain are responsible for stage-specific transcriptional regulation, and belong to the only known family of transcription factors in Plasmodium parasites. A comprehensive identification of their target genes will advance our understanding of the molecular basis of stage-specific parasite development. more...

Organism:

Plasmodium berghei

Type:

Expression profiling by high throughput sequencing

Platform:

GPL18820

1 Sample

Download data: TXT

(Submitter supplied) Stage-specific transcription is a fundamental biological process in the lifecycle of the Plasmodium parasite. Proteins containing the AP2 DNA-binding domain are responsible for stage-specific transcriptional regulation, and belong to the only known family of transcription factors in Plasmodium parasites. A comprehensive identification of their target genes will advance our understanding of the molecular basis of stage-specific parasite development. more...

Organism:

Plasmodium berghei; Plasmodium berghei ANKA

Type:

Expression profiling by array

Platform:

GPL15092

12 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Plasmodium berghei

Type:

Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:

GPL23133 GPL18820 GPL32636

12 Samples

Download data

(Submitter supplied) Sporozoite is the stage in which malaria parasites initially infect the vertebrate host. Elucidation of gene regulation in this stage will promote the investigation of mechanisms of liver infection by this parasite and contribute to development of strategies for preventing the malaria transmission. AP2-Sp is a transcription factor essential for formation of sporozoites or sporogony, which take place in oocysts on the midgut of infected mosquitoes. more...

Organism:

Plasmodium berghei

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platforms:

GPL18820 GPL23133

4 Samples

Download data: BEDGRAPH, XLSX

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Plasmodium berghei ANKA

Type:

Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

Platforms:

GPL19817 GPL19816

22 Samples

Download data: BEDGRAPH, TXT

(Submitter supplied) Gametocytes are nonreplicative sexual forms that mediate malaria transmission to a mosquito vector. They are generated from asexual blood stage parasites, which proliferate in the circulation. However, it remains largely unknown as to how this transition is genetically regulated. Here, we report that an Apetala2 (AP2) family transcription factor, AP2-G2, regulates the transition as a transcriptional repressor. more...

Organism:

Plasmodium berghei ANKA

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL19817

4 Samples

Download data: BEDGRAPH, TXT

(Submitter supplied) Gametocytes are nonreplicative sexual forms that mediate malaria transmission to a mosquito vector. They are generated from asexual blood stage parasites, which proliferate in the circulation. However, it remains largely unknown as to how this transition is genetically regulated. Here, we report that an Apetala2 (AP2) family transcription factor, AP2-G2, regulates the transition as a transcriptional repressor. more...

Organism:

Plasmodium berghei ANKA

Type:

Expression profiling by array

Platform:

GPL19816

18 Samples

Download data: TXT

(Submitter supplied) Sporozoite-specific genes were induced in parasites that express AP2-O whose AP2 domain was swapped with that of AP2-Sp.

Organism:

Plasmodium berghei

Type:

Expression profiling by array

Platform:

GPL9539

21 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Plasmodium berghei ANKA

Type:

Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

Platforms:

GPL15092 GPL19670

13 Samples

Download data: BEDGRAPH, BW, TXT

(Submitter supplied) Malaria gametocytes, the precursors of gametes, is the stage essential for malaria transmission to the mosquito vector. In the circulation they arise from asexual erythrocytic stages and then develop into mature females and males. Identification of sex-specific transcription factors is a key to understand biology of this stage. However, despite of intensive studies, none of them have been identified yet. more...

Organism:

Plasmodium berghei ANKA

Type:

Expression profiling by array

Platform:

GPL15092

9 Samples

Download data: TXT

(Submitter supplied) Malaria gametocytes, the precursors of gametes, is the stage essential for malaria transmission to the mosquito vector. In the circulation they arise from asexual erythrocytic stages and then develop into mature females and males. Identification of sex-specific transcription factors is a key to understand biology of this stage. However, despite of intensive studies, none of them have been identified yet. more...

Organism:

Plasmodium berghei ANKA

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL19670

4 Samples

Download data: BEDGRAPH, BW, TXT

(Submitter supplied) During the progress through its complex life cycle, the malaria parasite requires strict control of gene expression but the mechanism controlling this process remain poorly understood and unexplored for therapeutic purposes. A group of the apicomplexa-specific putative transcription factors with AP2 DNA binding domain (apiAP2) has been identified as the major regulators of the parasite transcriptome at multiple stages. more...

Organism:

Plasmodium berghei

Type:

Expression profiling by high throughput sequencing

Platform:

GPL20293

62 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Plasmodium berghei; Plasmodium berghei ANKA

Type:

Expression profiling by array

Platforms:

GPL15077 GPL15092

27 Samples

Download data: TXT

(Submitter supplied) In the rodent malaria parasite Plasmodium berghei, we found that an AP2 family transcription factor designated AP2-L plays a critical role in the development of the liver stage. Using DNA microarray analysis we showed that the expression of several genes, including those of parasitophorous vacuole membrane proteins, was significantly decreased in the early liver stage of AP2-L-depleted parasites.

Organism:

Plasmodium berghei; Plasmodium berghei ANKA

Type:

Expression profiling by array

Platform:

GPL15092

17 Samples

Download data: TXT

(Submitter supplied) In the rodent malaria parasite Plasmodium berghei, we found that an AP2 family transcription factor designated AP2-L plays a critical role in the development of the liver stage. Using DNA microarray analysis we showed that the expression of several genes, including those of parasitophorous vacuole membrane proteins, was significantly decreased in the early liver stage of AP2-L-depleted parasites.

Organism:

Plasmodium berghei; Plasmodium berghei ANKA

Type:

Expression profiling by array

Platform:

GPL15077

10 Samples

Download data: TXT

(Submitter supplied) To determine the genome-wide occupancy of the Plasmodium falciparum transcriptional regulator of invasion PfAP2-I (PfDd2_100013100/PF3D7_1007700), we used chromatin immunoprecipitation coupled with next-generation sequencing (ChIP-seq). Synchronized, schizont stage, 40 hours post-invasion, cultures of parasites expressing the AP2-I-GFP fusion protein were treated with formaldehyde to crosslink proteins to DNA and harvested. more...

Organism:

Plasmodium falciparum

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL21078

9 Samples

Download data: BEDGRAPH

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Plasmodium yoelii yoelii

Type:

Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:

GPL29103 GPL29104

10 Samples

Download data: BW