Similar studies for GEO DataSets (Select 200140324) - GEO DataSets

(Submitter supplied) Transition between differentiation states in development occurs swift but the mechanisms leading to epigenetic and transcriptional reprogramming are poorly understood. The pediatric cancer neuroblastoma includes adrenergic (ADRN) and mesenchymal (MES) tumor cell types, which differ in phenotype, super-enhancers (SEs) and core regulatory circuitries. These cell types can spontaneously interconvert, but the mechanism remains largely unknown. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL20301
4 Samples

Download data: BED

Series

Accession:: GSE129980

ID:: 200129980

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001168935.

NOTCH3-IC

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL20301 GPL570
26 Samples

Download data: BED, CEL

Series

Accession:: GSE116893

ID:: 200116893

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Select item 2001168926.

Xenograft SH-SY5Y tumors with inducible NOTCH3-IC expression.

(Submitter supplied) Expression analysis of xenograft tumors of ADRN cell line SH-SY5Y with doxycycline-inducible NOTCH3-IC was used to study transcriptional reprogramming to a MES state in vivo.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
8 Samples

Download data: CEL

Series

Accession:: GSE116892

ID:: 200116892

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Select item 2001168917.

Reversible induction NOTCH3-IC in SH-SY5Y.

(Submitter supplied) Expression analysis of ADRN cell line SH-SY5Y with transient- or permanent doxycycline-inducible NOTCH3-IC expression was used to study reversibility of transcriptional reprogramming.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
5 Samples

Download data: CEL

Series

Accession:: GSE116891

ID:: 200116891

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Select item 2001168908.

Time-course inducible NOTCH3-IC expression in SH-SY5Y.

(Submitter supplied) Expression analysis of ADRN cell line SH-SY5Y with doxycycline-inducible NOTCH3-IC was used to study transcriptional reprogramming to a MES state.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
9 Samples

Download data: CEL

Series

Accession:: GSE116890

ID:: 200116890

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Select item 2000974269.

Mesenchymal (MES)- and Adrenergic (ADRN) neuroblastoma cell line pairs of isogenic origin

(Submitter supplied) Cell line pairs with different phenotypes were isolated from individual patients to study intra-tumor heterogeneity in neuroblastoma

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
13 Samples

Download data: CEL

Series

Accession:: GSE97426

ID:: 200097426

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Select item 20009102810.

Neuroblastoma is composed of two super enhancer-associated differentiation states

(Submitter supplied) Intra-tumour heterogeneity is increasingly appreciated as a determinant of tumour recurrence. Several tumour types were recently found to include phenotypically divergent cell types, reflecting lineage development stages (1,2,3). Lineage identity has been proposed to ensue super-enhancer (SE)-associated transcription factor (TF) networks (4,5), but their role in intra-tumour heterogeneity is unknown. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL20148 GPL16791
31 Samples

Download data: BED

Series

Accession:: GSE91028

ID:: 200091028

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20009080511.

Mesenchymal differentiation of neuroblastoma cell lines

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL20148 GPL570 GPL16791
69 Samples

Download data: BED, CEL

Series

Accession:: GSE90805

ID:: 200090805

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Select item 20009080412.

PRRX1 over-expression in SK-N-BE(2C)

(Submitter supplied) PRRX1 is expressed in mesenchymal-type neuroblastoma cells. Over-expression of PRRX1 in adrenergic-type cell line was used to study reprogramming towards a mesenchymal lineage.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
17 Samples

Download data: CEL

Series

Accession:: GSE90804

ID:: 200090804

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Select item 20009080313.

Mesenchymal (MES)- and Adrenergic (ADN) neuroblastoma cell line pairs of isogenic origin

(Submitter supplied) Cell line pairs with different phenotypes were isolated from individual patients to study intra-tumor heterogeneity in neuroblastoma

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
8 Samples

Download data: CEL

Series

Accession:: GSE90803

ID:: 200090803

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20007018614.

TCF12 Expression Profiles in HNSCC

(Submitter supplied) To investigate the regulation of TCF12 on downstream genes in OSCC, we performed GeneChip analysis using OECM1 expression cell subclones and HSC3 knockdown cell subclones.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
4 Samples

Download data: CEL

Series

Accession:: GSE70186

ID:: 200070186

Select item 20011965415.

Proline 152 mutation in p53 abolishes cognate DNA binding, induces gain of function tumorigenesis

(Submitter supplied) We have identified a relatively rare mutation in p53 in an Indian oral cancer patient sample at the fade end of its DNA binding domain [P152L]. Although P152L p53 DBD potentially binds to DNA, the full length protein is completely devoid of cognate site DNA binding ability. Also the mutant protein can efficiently tetramerize. Significantly, this mutant was found to induce cell mobility and proliferation with greater tumorigenic potential in nude mice, the mechanistic details of which is also investigated upon. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
4 Samples

Download data: TXT

Series

Accession:: GSE119654

ID:: 200119654

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Select item 20003127716.

MicroRNA expression profile in Head and Neck Cancer: HOX-cluster embedded microRNA-196 and microRNA-10b dysregulation is implicated in cell proliferation

(Submitter supplied) Current evidence implicates aberrant microRNA expression patterns in human malignancies; measurement of microRNA expression may have diagnostic and prognostic applications. Roles for microRNAs in head and neck squamous cell carcinomas (HNSCC) are largely unknown. HNSCC, a smoking-related cancer, is one of the most common malignancies worldwide but reliable diagnostic and prognostic markers have not been discovered so far. more...

Organism:: Homo sapiens

Type:: Expression profiling by array; Non-coding RNA profiling by array

Platforms:: GPL4133 GPL10332 GPL9770
42 Samples

Download data: TXT

Series

Accession:: GSE31277

ID:: 200031277

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Select item 20006539017.

miRNA expression-based, individualized outcome prediction for SDT treatment in melanoma

(Submitter supplied) Individualized outcome prediction classifiers were successfully constructed through expression profiling of a total of 3100 capture probes, covering all human, mouse and rat microRNAs annotated in miRBase 18.0, in 8 melanoma samples divided into 4 groups (Control, ALA, US, and SDT group).

Organism:: synthetic construct; Mus musculus

Type:: Non-coding RNA profiling by array

Platform:: GPL17107
8 Samples

Download data: TXT

Series

Accession:: GSE65390

ID:: 200065390

PubMed Similar studies

Select item 20016775318.

RNA from 4T1 tumors in mice treated with miR-loaded EVs

(Submitter supplied) RNA was harvested from 4T1 tumors in mice treated with miR-loaded EVs

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
12 Samples

Download data: TXT

Series

Accession:: GSE167753

ID:: 200167753

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20016775219.

RNA from RAW 264.7 cells treated with miR-loaded extracellular vesicles

(Submitter supplied) RNA was harvested from RAW 264.7 cells treated with miR-loaded extracellular vesicles

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
12 Samples

Download data: TXT

Series

Accession:: GSE167752

ID:: 200167752

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20016775120.

Small RNA in endothelial cells and EVs cultured alone or with tumor cells

(Submitter supplied) RNA was harvested from endothelial cells cultured alone or with tumor cells and the associated endothelial extracellular vesicles.